Uterine Artery Embolization Versus Occlusion for Uterine Leiomyomas: A Pilot Randomized Clinical Trial

Surgical Management of Abnormal Uterine Bleeding in Fertile Age Women

“…On the other side, UAE seems to have a higher risk of minor complications and higher rate of further surgery within 2-5 years from the first procedure and, since it may be associated with a higher risk of preterm labor, intrauterine growth restriction and postpartum hemorrhage, it should be carefully suggested in patients with future pregnancy desire. Similar results come from localized uterine artery occlusion [103,104], both with electrodessication or clips managed laparoscopically and with coils deposited in the uterine artery [105].…”

Use of uterine vessel occlusion in the management of uterine myomas: two different approaches

“…Some studies have reported the use of the UVO procedure in the management of uterine fibroids (12,15,18,20,27,28,(31)(32)(33)(34), and other studies the use of the UAO procedure for the same purpose (16,21,22,25,26,29,(31)(32)(33)(34)(35)(36)(37)(38)(39). However, the differences between the two procedures, especially in terms of patient suffering and outcome, are rarely evaluated.…”

Choice of primary and secondary outcomes in randomised controlled trials evaluating treatment for uterine fibroids: a systematic review

“…The outcome measures used to assess menstrual blood loss included the Pictorial Blood Loss Assessment Chart (five RCTs), the number of sanitary tampons or napkins used (two RCTs) and the Menorrhagia Impact Questionnaire (two RCTs), the Aberdeen Menorrhagia Severity Score (two RCTs), menstruation duration (one RCT), duration of heavy menstruation (one RCT), presence of blood clots (one RCT), number of pads used on the heaviest day of bleeding (one RCT) and no specified outcome measure (one RCT). 13,14,19,25,27,31,37,82,83,85 For the QoL domain, QoL was reported as a primary outcome in four RCTs and as a secondary outcome in 12 RCTs. The validated Uterine Fibroid Symptom and QoL Questionnaire was used as a measure in nine trials.…”

“…After exclusion of 1884 duplicates, 1885 titles and abstracts were screened (Figure 1) and 389 full texts were assessed for eligibility. After a further exclusion of 309 records, 60 RCTs were included in the systematic review that were published between 1990 and 2021 (median 2009) 10‐69 . The included studies involved 5699 participants.…”

“…The most frequently reported primary outcomes were postoperative pain (seven RCTs, three outcome measures), 13,30,51,53,60,70,71 QoL (six RCTs, four outcome measures), 25,27,55,72,73,74 menstrual bleeding (four RCTs, three outcome measures) 14,17,25,29 and discharge time (four RCTs) 52,57,62,65 (Table 1). The secondary outcomes most frequently reported were postoperative pain (25 RCTs, seven outcome measures), 14,16,17,25,33,35,52,54,57,61,63,65,70,74,75,76,77,78,79,80,81,82,83,84,85,86 complications (21 RCTs, four outcome measures) 16,17,25,33,36,56,70,72,73,74,76,77,79,81,83,84,87,88,89,90,91,92 and operative time (16 RCTs) 22,36,47,48,56,57,58,59,61,62,63,64,65,77,86,93,94 (Table S2).…”