Uterine blood flow evaluation in bitches suffering from cystic endometrial hyperplasia (CEH) and CEH-pyometra complex

Batista, Pablo Rodrigo; Gobello, Cristina; Rube, A.; Corrada, Yanina Alejandra; Tortora, M; Blanco, Paula Graciela

doi:10.1016/j.theriogenology.2015.12.008

Cited by 23 publications

(37 citation statements)

References 23 publications

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“…Ultrasonography is the diagnostic imaging technique usually preferred in suspected pyometra cases, because it provides detailed information of not only about the uterus size, but also thickness, presence of fibrosis or cysts in the endometrium, and appearance of the uterine fluid (Bigliardi et al., ). Additionally, the uterine blood‐flow detectable has been shown to aid in the differentiation of pyometra versus mucometra in cases with fluid‐filled uterus (Batista et al., ). For treatment of pyometra, advance has been made in both surgical and purely medical treatment.…”

Section: What Is New About Diagnosis and Treatment Of Pyometra?mentioning

confidence: 99%

Canine pyometra: What is new?

Hagman

2016

Reprod Domestic Animals

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Section: What Is New About Diagnosis and Treatment Of Pyometra?mentioning

confidence: 99%

Canine pyometra: What is new?

Hagman

2016

Reprod Domestic Animals

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“…In dogs, Doppler ultrasound has proved to be able to differentiate pyometra from other uterine conditions (Batista et al, 2016;Veiga et al, 2017). However, the use of Doppler ultrasound to assess feline pyometra has not been reported so far.…”

Section: Introductionmentioning

confidence: 99%

Uterine two‐dimensional and Doppler ultrasonographic evaluation of feline pyometra

Blanco

Rube

Merlo

et al. 2018

Reprod Domestic Animals

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Contents The aim of this study was to compare uterine two‐dimensional and Doppler ultrasonographic parameters in queens suffering from pyometra from those in early pregnancy. Secondly, the effect of the presence of clinical signs of systemic illness on these parameters was also described. Fourteen post‐oestrous queens, with uterine luminal content in the absence of embryos were included. According to their outcome (pyometra surgery or parturition), the queens were retrospectively assigned to one of the following groups: Pyometra (PYO; n = 7) or pregnant (PRG; n = 7). In all the queens, two‐dimensional and Doppler ultrasound examinations of the uterus were performed. The presence or absence of clinical signs of systemic illness was recorded. The widest cross‐sectional diameter (UD), uterine wall thickness (WT), uterine lumen contents (LC) and uterine artery resistance index (RI) were measured. Uterine horn diameter was higher in PYO group than in PRG group (p < 0.05), while WT (p > 0.1) and LC (p = 0.09) did not differ between groups. Values of RI for PYO and PRG groups were 0.61 ± 0.03 vs 0.53 ± 0.09 (p < 0.05), respectively. PYO cats suffering from clinical signs of systemic illness showed larger UD than those without signs (p < 0.01). It is concluded that two‐dimensional and Doppler ultrasound might be useful to distinguish queens suffering from pyometra from those in early pregnancy. Secondly, the clinical signs of systemic illness were associated with a larger UD.

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“…The widespread distribution of the contrast medium in the hyperplastic endometrial mucosa provides accurate qualitative and quantitative information about uterine microvascularization and attests severe vascularization. Previous studies, focusing on Doppler investigations of flow of uterine arteries, showed a high speed with low resistance flow (low resistance index, RI) in bitches with CEH-pyometra syndrome compared with normal subjects in diestrous and bitches with mucometra [ 2 , 17 ]. Authors related these hemodynamic results to endometrial neovascularization and increased tissue perfusion resulting from inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…In dogs, ultrasonographic evaluation of the uterus permits determining the thickness of the uterine walls and the presence of luminal contents differentiating pregnancy from pathologic conditions [ 12 , 13 ]. In women and cows, the increase in blood flow due to uterine pathologic conditions can be detected by Doppler ultrasound, but in dogs, this technique has been used to evaluate the blood flow of the uterine arteries during estrus, normal and abnormal pregnancies and the puerperium [ 14 , 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Contrast-Enhanced Ultrasound in Cystic Endometrial Hyperplasia–Pyometra Complex in the Bitch: A Preliminary Study

Quartuccio

Liotta

Cristarella

et al. 2020

Animals

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In cystic endometrial hyperplasia (CEH)–pyometra syndrome, toxic factors and endometrial remodeling culminate in changes characterized by exudative and degenerative inflammatory reaction. Recent studies on hemodynamic found an increased blood flow and lower vascular resistance in uterine arteries, suggesting color Doppler ultrasound as an adjunctive tool for quantitative assessment of endometrial vascularization during pyometra. The aim of this study was to assess, through contrast-enhanced ultrasound (CEUS) exam, the vascularization in endometrial microvessels in CEH-pyometra in order to evaluate the possibility of application in this syndrome. In twelve female dogs with clinical symptoms related to pyometra, B-mode, color Doppler and CEUS exams were performed. In CEH-pyometra uteri, histopathological examination revealed severe CEH and pyometra, immunohistochemical stain with CD 34 confirmed the presence of angiogenesis. CEUS exams revealed a widespread, intense and rapidly developing homogeneous enhancement of the hyperplastic endometrium, with absence of signal only in cystic areas. All parameters of the quantitative analysis were not significantly influenced by region of interest dimension and position. CEUS has the potential to improve clinical not invasive evaluations in the CEH-pyometra syndrome and virtually in CEH-mucometra.

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Uterine blood flow evaluation in bitches suffering from cystic endometrial hyperplasia (CEH) and CEH-pyometra complex

Cited by 23 publications

References 23 publications

Canine pyometra: What is new?

Canine pyometra: What is new?

Uterine two‐dimensional and Doppler ultrasonographic evaluation of feline pyometra

Contrast-Enhanced Ultrasound in Cystic Endometrial Hyperplasia–Pyometra Complex in the Bitch: A Preliminary Study

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