Uterine distension and the function of the corpora lutea in the guinea‐pig

Bland, K. P.; Donovan, B. T.

doi:10.1113/jphysiol.1966.sp008052

Cited by 25 publications

(18 citation statements)

References 9 publications

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“…Recent reviews (1,2) affirm that the IUCD inhibits sperm transport in fowls and sheep (1,3), delays LH release and ovulation in rabbits (4), inhibits ovulation in Holstein heifers and water buffalo (5,6), alters uterine motility and capacity in sheep and humans (7,8,9) causes sterile inflammation of the endometrium in rats and humans (10,11,12,13), changes the endometrial content of calcium and phosphatases in monkeys and humans (14,15) and modifies responses to estrogens and progestogens in rats (16,17,18). IUCD's impair corpus luteal function in rabbits, guinea-pigs, cattle, sheep and pigs (4,19,20,21,22) but evidence for this effect in primates is conflicting. A shortening of the menstrual cycle was reported in rhesus monkeys and in humans after insertion of an IUCD but this effect was considered to be of no biological significance (23,24).…”

mentioning

confidence: 98%

The Effect of Intrauterine Contraceptive Devices on Ovarian and Menstrual Function in the Human

Martin

Brown

1973

The Journal of Clinical Endocrinology & Metabolism

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The effects of IUCD's on ovarian and menstrual function were studied in 10 women throughout at least 2 menstrual cycles, one in which an IUCD was in place and the other was a control. Ovarian function was monitored and ovulation was dated by serial measurements of urinary estrogens and pregnanediol and of plasma progesterone. The steroid levels in all cycles showed the characteristic pattern of the ovulatory cycle with the values falling within the normal ranges. No significant differences in output of estrogens or pregnanediol could be detected between control and IUCD cycles and there was no evidence that the IUCD influenced follicular development, ovulation or the function of the corpus luteum. However, the lengths of the luteal phases, calculated as the interval between the mid-cycle estrogen peak and onset of menstrual bleeding, were shorter in the IUCD cycles than in their controls, the mean differences being 2.3 days which was highly significant (p < 0.001). Even so, the durations of the luteal phases in 70% of the IUCD cycles were still within the range found in normal fertile women and therefore the shortening could not itself explain the contraceptive action of the IUCD. The estrogen and pregnanediol values were significantly higher on the day before onset of bleeding in the IUCD cycles than in their controls. It was concluded that the shorter luteal phases in the IUCD cycles were not due to earlier hormone changes but were due to local effects of the IUCD which caused earlier shedding of the endometrium. (/ Clin Endocrinol Metab 36: 1125, 1973

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mentioning

confidence: 98%

The Effect of Intrauterine Contraceptive Devices on Ovarian and Menstrual Function in the Human

Martin

Brown

1973

The Journal of Clinical Endocrinology & Metabolism

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“…Histological examination of the ovaries This was kindly performed by Dr. K. P. Bland, who measured the size and number of corpora lutea in each ovary, using the method of Bland & Donovan (1966). On the basis of these measurements and of the general appearance of the ovaries he was able to assess the functional state at the time of death without knowing the origin of the samples he was examining.…”

Section: Indomethacin Injectionsmentioning

confidence: 99%

Elongation of oestrous cycle in the guinea‐pig following subcutaneous or intra‐uterine administration of indomethacin

Horton

Poyser

1973

British J Pharmacology

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Summary Guinea‐pigs injected subcutaneously with 10 mg indomethacin twice daily, from day 7 of the oestrous cycle, had their oestrous cycles significantly lengthened (P < 0·001) by about 3 days. When the indomethacin was incorporated into a slow‐release preparation and placed in the uterus (33 mg per horn), the oestrous cycle lengths of these guinea‐pigs were greatly prolonged and approached that produced by hysterectomy. The measurement of corpora luteal size and progesterone levels in some of the guinea‐pigs autopsied on day 47 of the extended cycle showed functional corpora lutea to be present. It was apparent that indomethacin had prolonged the life span of the corpus luteum. This would account for the increase in the length of the oestrous cycle. Recent investigations suggest that normal corpora luteal regression, with the termination of the oestrous cycle, is induced by prostaglandin F2α released from the uterus on day 15. Since indomethacin prevents prostaglandin biosynthesis, it is probable in these experiments that this drug had prevented luteal regression by inhibiting the biosynthesis by, and release from, the uterus of prostaglandin F2α in luteolytic concentrations. These results provide further evidence that the uterine luteolytic hormone in guinea‐pigs is prostaglandin F2α.

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“…These results are in agreement with those of Henricks (1971). The expected shortening of cycle length (Bland & Donovan, 1966) was not always seen. In the present experiments, the injection of PGF2a always had an adverse effect on luteal function regardless of the time of administration.…”

Section: Discussionmentioning

confidence: 89%

Effect of Intra-Uterine Foreign Bodies and of Prostaglandin Administration on Progesterone Secretion During the Oestrous Cycle of the Guinea-Pig

Blatchley¹,

Donovan²

1976

Journal of Endocrinology

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The response of the guinea-pig corpus luteum to the luteolytic influence of glass beads placed in the uterus, or to prostaglandin administration, was followed by assay of the progesterone content of blood samples collected daily. Following the introduction of glass beads into the uterus early in the cycle, the secretion of progesterone was curtailed. Treatment with prostaglandin F2alpha over days 4-6 or 6-8 of the cycle temporarily depressed progesterone release without shortening the life of the corpora lutea. When the drug was administered over days 8-10, 10-12 or 12-14 the depression in progesterone was not followed by any recovery. These observations indicate that the response of the corpora lutea to a luteolytic influence changes during the oestrous cycle.

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Uterine distension and the function of the corpora lutea in the guinea‐pig

Cited by 25 publications

References 9 publications

The Effect of Intrauterine Contraceptive Devices on Ovarian and Menstrual Function in the Human

The Effect of Intrauterine Contraceptive Devices on Ovarian and Menstrual Function in the Human

Elongation of oestrous cycle in the guinea‐pig following subcutaneous or intra‐uterine administration of indomethacin

Effect of Intra-Uterine Foreign Bodies and of Prostaglandin Administration on Progesterone Secretion During the Oestrous Cycle of the Guinea-Pig

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