Uterine fluid from bitches with mating-induced endometritis reduces the attachment of spermatozoa to the uterine epithelium

Freeman, Sarah; Green, Martin J.

doi:10.1016/j.tvjl.2013.06.026

Cited by 7 publications

(3 citation statements)

References 21 publications

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“…Changes in bitches' reproductive systems were mainly in the ovaries and the uterus, including the degeneration of cells, inhibition of biological activity in the ovaries, and edema and extravasations in the uterus [18]. Exposure to low doses of ZEA has been linked with permanent uterine dysfunction, frequently leading to the spontaneous endometritis-pyometra complex [20][21][22].…”

Section: Reproductive Disordersmentioning

confidence: 99%

Endocrine-Disrupting Chemicals and Their Effects in Pet Dogs and Cats: An Overview

Pocar

Grieco

Aidos

et al. 2023

Animals

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Over the past few decades, several pollutants classified as environmental endocrine-disrupting chemicals (EDCs) have become a matter of significant public health concern. Companion animals play a major role in human society, and pet ownership is substantially increasing worldwide. These intimate human–pet relationships imply sharing much of the same environment, thus including exposure to similar levels of EDCs in daily routine. Here, we review the current knowledge on the sources and routes of exposure to EDCs in domestic indoor and outdoor environments and discuss whether endocrine disruption is a health concern in pets. We summarize the phenomenon of endocrine disruption, providing examples of EDCs with a known impact on dog and cat health. Then, we propose an overview of the literature on the adverse effects of EDCs in domestic pets, with a special focus on the health of reproductive and thyroid systems. Finally, we explore the potential role of companion animals as unintentional sentinels of environmental exposure to EDCs and the implications for public health risk assessment in a “shared risk” scenario. Overall, this review supports the need for an integrated approach considering humans, animals, and the environment as a whole for a comprehensive assessment of the impact of EDCs on human and animal health.

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Section: Reproductive Disordersmentioning

confidence: 99%

Endocrine-Disrupting Chemicals and Their Effects in Pet Dogs and Cats: An Overview

Pocar

Grieco

Aidos

et al. 2023

Animals

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“…Persistence of luminal fluid appears to reduce the attachment of spermatozoa to uterine epithelium and reduces fertility (Freeman et al. ,b).…”

Section: Sperm Removalmentioning

confidence: 99%

Current Knowledge on the Transport and Fate of Spermatozoa in the Reproductive Tract of the Bitch

Rijsselaere

Freeman

Maes

et al. 2014

Reprod Domestic Animals

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ContentsCanine sperm transport, distribution, storage and detachment is a complex, dynamic and highly regulated process. Transport of sperm within the bitch's reproductive tract is rapid and is influenced by the method of semen deposition (natural mating or artificial insemination) and by the timing of breeding in relation to the day of ovulation. The fertile lifespan of spermatozoa in the reproductive tract of the bitch is considerably longer than in most other domestic species, and the main sperm reservoirs appear to be the uterine crypts and the distal part of the uterotubal junction, where spermatozoa attach by their heads to uterine epithelium. While several in vitro studies demonstrated prolonged motility and viability of canine spermatozoa after coincubation with uterine tube explants, spermatozoal storage has not been documented in the canine uterine tube isthmus or ampulla in vivo. Several factors, including exposure to progesterone, solubilized zona pellucida proteins and post-ovulation uterine tube fluid, appear to trigger membrane events resulting in capacitationlike changes with subsequent motility pattern changes (transitional and hyperactivated) that are associated with sperm detachment. After mating or insemination, a normal lowmagnitude post-mating uterine inflammatory response occurs, evidenced by an influx of polymorphonuclear neutrophils (PMNs), increased uterine contractions and an increased uterine artery blood flow. Recently, it was also shown that normal dogs with cystic endometrial hyperplasia develop a more significant endometritis, show fewer mating-induced uterine contractions, a decreased ability of spermatozoa to bind to uterine explants in vitro and a slower uterine clearance after mating.

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“…This review focuses on inflammation, trying to distinguish it from the effects of bacterial infections (including Lipopolysaccharide -LPS) and on the bovine female, despite inflammation is closely associated to many physiological and pathological aspects of reproduction in many other species, if not all (e.g. Freeman et al, 2013 in the bitch or Katila, 2012 in the mare).…”

Section: Introductionmentioning

confidence: 99%

Inflammation: friend or foe of bovine reproduction?

Chastant-Maillard¹,

Saint‐Dizier²

2019

Anim Reprod

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Uterine fluid from bitches with mating-induced endometritis reduces the attachment of spermatozoa to the uterine epithelium

Cited by 7 publications

References 21 publications

Endocrine-Disrupting Chemicals and Their Effects in Pet Dogs and Cats: An Overview

Endocrine-Disrupting Chemicals and Their Effects in Pet Dogs and Cats: An Overview

Current Knowledge on the Transport and Fate of Spermatozoa in the Reproductive Tract of the Bitch

Inflammation: friend or foe of bovine reproduction?

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