Uterine microbiota and its effect on reproductive outcomes

Keburia, Keburia L.K.; Smolnikova, Smolnikova V.Yu.; Priputnevich, Priputnevich T.V.; Muravyeva, Muravyeva V.V.

doi:10.18565/aig.2019.2.22-27

Cited by 2 publications

(2 citation statements)

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“…Much research is still needed, however, to assess the impact of external factors and how they could be controlled [26]. Taken together, recent studies confirm the importance of investigating the female microbiota prior to an IVF cycle looking for microorganisms associated with poor outcomes using cultures, as well as using more advanced technology to characterize the complete microbiome associated with the best pregnancy outcomes [14].…”

Section: Influence Of the Microbiome On Female Fertilitymentioning

confidence: 92%

“…Usually, some attention is given to the occurrence of microorganisms in our bodies only when they are associated with an active infection; however, the human body is in constant interaction with its personal ecological community of microorganisms, called microbiota, which have direct influence in many aspects of human physiology, including reproductive health. Research in this field is relatively incipient but recent studies have shown how this interaction might influence IVF results [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Microbial contamination in assisted reproductive technology: source, prevalence, and cost

Borges

Berteli

Reis

et al. 2019

J Assist Reprod Genet

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Even the strictest laboratories and clinics are prone to the occurrence of microbial contamination. In the case of in vitro fertilization (IVF) research and practice facilities, the number of possible sources is particularly vast. In addition to ambient air, personnel, and non-sterilized materials, follicular fluid and semen from patients are a very common gateway for a diverse range of bacteria and fungi into embryo cultures. Even so, reports of contamination cases are rare, what leads many clinics to see the issue as a negligible risk. Microbiological contamination may result in the demise of the patient's embryos, leading to additional costs to both the patient and the clinics. Regardless of financial loss, emotional costs, and stress levels during IVF are highly distressing. Other worrisome consequences include DNA fragmentation, poor-quality embryos, early pregnancy loss or preterm birth, and possible long-term damages that need further investigation. In this review, we aimed to shed a light on the issue that we consider largely underestimated and to be the underlying cause of poor IVF outcomes in many cases. We also discuss the composition of the microbiome and how its interaction with the reproductive tract of IVF-seeking patients might influence their outcomes. In conclusion, we urge clinics to more rigorously identify, register, and report contamination occurrences, and highlight the role of the study of the microbiome to improve overall results and safety of assisted reproduction.

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Section: Influence Of the Microbiome On Female Fertilitymentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%