Uteroglobin Expression and Release in the Human Endometrium

Müller-Schöttle, Frank; Claßen-Linke, I.; Beier-Hellwig, K.; Sterzik, K.; Beier, Henning M.

doi:10.1111/j.1749-6632.2000.tb05544.x

Cited by 16 publications

(11 citation statements)

References 6 publications

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“…Detection of expression of UGL requires treatment with progesterone for several days, maybe due to a time-dependent epithelial differentiation initiated and maintained by progesterone (Müller-Schöttle et al 2000). Accordingly, the increased UGL expression intensity was associated with a decrease in concentrations of serum progesterone.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical and histochemical identification of proteins and carbohydrates in the equine endometrium: Reaction patterns in the cycling mare

Hoffmann¹,

Bazer²,

Klug³

et al. 2009

PHK

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical and histochemical identification of proteins and carbohydrates in the equine endometrium: Reaction patterns in the cycling mare

Hoffmann¹,

Bazer²,

Klug³

et al. 2009

PHK

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“…21 Mammaglobin B, which is also known as human secretoglobin (SCGB) 2A1 (lacryglobin, lipophilin C), is a small protein that forms heterodimers with secretoglobin 1D1 (lipophilin A) in tears. 33 Mammaglobin B is known to be normally expressed in salivary gland, mammary gland, human endometrium, 34 pituitary, testis, trachea, and ovary. 35 On the ocular surface, besides its high abundance in tear film, it is expressed in lacrimal gland, glands of Moll, and meibomian glands of the eyelid, as well as in the epithelium of the conjunctiva.…”

Section: Figure 5 (A) Western Blot Analysismentioning

confidence: 99%

Proteomic Profiling of Inflammatory Signaling Molecules in the Tears of Patients on Chronic Glaucoma Medication

Wong

Zhou

et al. 2011

Invest. Ophthalmol. Vis. Sci.

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Treatment with topical antiglaucoma medications for longer than 1 year may start to induce ocular surface inflammation. The inflammatory tear protein profile present in chronically medicated glaucomatous eyes appears to be different from that found in primary dry eye. Identification of tear proteins specific to medicated glaucomatous eyes will help to specifically develop targeted screening modalities and therapeutic agents different from current conventional dry eye management.

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“…The main difference between rodents and humans is that Club cells are found more frequently in the trachea and bronchi of rodents, while they are less abundant in the large airways of humans. Other organs that contain CC16-secreting cells are the prostate, ovaries, pancreas, mammary glands, and uterine endometrium 8;9 . However, there are conflicting reports on whether CC16 is expressed in the kidney 8;10 .…”

Section: Club Cell Protein-16 (Cc16)mentioning

confidence: 99%

Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD)

Laucho-Contreras

Polverino

Tesfaigzi

et al. 2016

Expert Opinion on Therapeutic Targets

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Introduction Club cell protein 16 (CC16) is the most abundant protein in bronchoalveolar lavage fluid. CC16 has anti-inflammatory properties in smoke-exposed lungs, and chronic obstructive pulmonary disease (COPD) is associated with CC16 deficiency. Herein, we explored whether CC16 is a therapeutic target for COPD. Areas Covered We reviewed the literature on the factors that regulate airway CC16 expression, its biologic functions and its protective activities in smoke-exposed lungs using PUBMED searches. We generated hypotheses on the mechanisms by which CC16 limits COPD development, and discuss its potential as a new therapeutic approach for COPD. Expert Opinion CC16 plasma and lung levels are reduced in smokers without airflow obstruction and COPD patients. In COPD patients, airway CC16 expression is inversely correlated with severity of airflow obstruction. CC16 deficiency increases smoke-induced lung pathologies in mice by its effects on epithelial cells, leukocytes, and fibroblasts. Experimental augmentation of CC16 levels using recombinant CC16 in cell culture systems, plasmid and adenoviral-mediated over-expression of CC16 in epithelial cells or smoke-exposed murine airways reduces inflammation and cellular injury. Additional studies are necessary to assess the efficacy of therapies aimed at restoring airway CC16 levels as a new disease-modifying therapy for COPD patients.

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Uteroglobin Expression and Release in the Human Endometrium

Cited by 16 publications

References 6 publications

Immunohistochemical and histochemical identification of proteins and carbohydrates in the equine endometrium: Reaction patterns in the cycling mare

Immunohistochemical and histochemical identification of proteins and carbohydrates in the equine endometrium: Reaction patterns in the cycling mare

Proteomic Profiling of Inflammatory Signaling Molecules in the Tears of Patients on Chronic Glaucoma Medication

Club Cell Protein 16 (CC16) Augmentation: A Potential Disease-modifying Approach for Chronic Obstructive Pulmonary Disease (COPD)

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