Utilisation du test GeneXpert pour le diagnostic de la tuberculose au service des maladies infectieuses du CHNU de Fann

Diop, Sylvie Audrey; Massaly, Aminata; Kà, Daye; Manga, N.M.; Fortes-Déguénonvo, L.; Ndour, Cheikh Tidiane; Cisse, Viviane Marie Pierre; Seydi, Moussa

doi:10.11604/pamj.2016.23.244.7442

Cited by 9 publications

(5 citation statements)

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“…We excluded one other article that reported on the specificity only [33], without reporting any sensitivity. We excluded five articles written in languages other than Chinese or English [34][35][36][37][38]. The specimens used in the article were pericardial effusion, pericardial tissue, or both.…”

Section: Identification Of Studies and Study Characteristicsmentioning

confidence: 99%

Diagnostic accuracy of the Xpert MTB/RIF assay for tuberculous pericarditis: A systematic review and meta-analysis

Zhong

Shen

et al. 2021

PLoS ONE

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Objective The purpose of this study was to evaluate the diagnostic efficacy of Xpert MTB/RIF for tuberculous pericarditis (TBP). Methods We searched relevant databases for Xpert MTB/RIF for TBP diagnosis until April 2021 and screened eligible studies for study inclusion. We evaluated the effectiveness of Xpert MTB/RIF when the composite reference standard (CRS) and mycobacterial culture were the gold standards, respectively. We performed meta-analyses using a bivariate random-effects model, and when the heterogeneity was obvious, the source of heterogeneity was further discussed. Results We included seven independent studies comparing Xpert MTB/RIF with the CRS and six studies comparing it with culture. The pooled sensitivity, specificity, and area under the curve of Xpert MTB/RIF were 65% (95% confidence interval, 59–72%), 99% (97–100%), and 0.99 (0.97–0.99) as compared with the CRS, respectively, and 75% (53–88%), 99% (90–100%), and 0.94 (0.92–0.96) as compared with culture, respectively. There was no significant heterogeneity between studies when CRS was the gold standard, whereas heterogeneity was evident when culture was the gold standard. Conclusions The sensitivity of Xpert MTB/RIF for diagnosing TBP was moderate and the specificity was good; thus, Xpert MTB/RIF can be used in the initial diagnosis of TBP.

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Section: Identification Of Studies and Study Characteristicsmentioning

confidence: 99%

Diagnostic accuracy of the Xpert MTB/RIF assay for tuberculous pericarditis: A systematic review and meta-analysis

Zhong

Shen

et al. 2021

PLoS ONE

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“…Research such as Hertz's has shown that a thorough understanding of social determinants is necessary to design effective treatments 9 . This is particularly crucial in the case of extrapulmonary tuberculosis, where concerns are raised about the limited use of bacteriological confirmation in diagnosis and treatment 16 .…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Therapeutic Approach to Drug-Sensitive Tuberculosis in Morocco: Retrospective Study from 2014 to 2017

Bejja,

Dahou,

Aboulhoda

et al. 2024

Bangladesh J Med Sci

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In countries like Morocco, drug-sensitive tuberculosis remains a major public health burden. Effective management of this condition is crucial, not only to achieve positive therapeutic outcomes for patients but also to curb its emergence and transmission. This study presents a detailed analysis of the therapeutic approach to drug-sensitive tuberculosis in Morocco. This retrospective study provides an overview of the therapeutic protocol used to treat drug-sensitive tuberculosis. The study examined all tuberculosis patients registered at the Tuberculosis and Respiratory Diseases Diagnostic Center in Kenitra from 2014 to 2017. A total of 5207 tuberculosis cases were recorded, with men comprising the majority of patients (63%) in this group, with a sex ratio of 1.7. The most affected age groups were 15 to 24 years and 25 to 34 years. Urban areas had a representation of 53%. The study revealed that 54% of cases were pulmonary, and extrapulmonary tuberculosis accounted for 46%. There were two main stages to the treatment regimens recommended by the WHO. During the initial phase, 96% of patients received a two-month quadritherapy (for new cases), 3% received a three-month regimen (for retreatment cases), and 2% received a three-drug therapy (for those under 15 years). This phase was followed by a continuation phase (bitherapy) lasting four to ten months. 82% of cases showed positive progression, 13% of patients experienced loss to follow-up, 1% had transfers out, and 2% of patients died. The study emphasizes the importance of integrating patient support, education on treatment, and the use of new technologies to enhance the monitoring and follow-up of tuberculosis patients. These measures could help reduce the morbidity and mortality associated with tuberculosis, contributing to overall health improvement. Bangladesh Journal of Medical Science Vol. 23 No. 02 April’24 Page : 521-526

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“…Chez notre patiente la recherche de BAAR dans les crachats était négative et la positivité du GeneXpert dans les crachats nous a permis de poser le diagnostic de la tuberculose pulmonaire en isolant Mycobacterium tuberculosis . Ceci conforte les conclusions d’une étude menée dans le même service qui confirmait la sensibilité du GeneXpert par rapport à la bacilloscopie [ 5 ]. D’où l’intérêt de mieux vulgariser cet examen dans le diagnostic de la tuberculose.…”

Section: Discussionunclassified

Co-infection Tuberculose/VIH et Maladie de kaposi sous traitement de substitution par la méthadone: à propos d’un cas

Diallo¹,

Déguénonvo²,

Mbaye³

et al. 2017

Pan Afr Med J

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Le diagnostic tardif de l’infection à VIH peut être fatal car favorisant l’apparition d’infections opportunistes dont la prise en charge nécessite l’utilisation de plusieurs molécules pouvant provoquer des interactions médicamenteuses. Nous rapportons le cas d’une patiente de 45 ans, sous traitement de substitution à l’héroïne par la méthadone, VIH1 sous traitement antirétroviral. Cette patiente présentait un tableau pulmonaire non spécifique associant une toux quinteuse sèche avec une dyspnée d’apparition progressive évoluant dans un contexte fébrile. Par ailleurs l’examen notait un lymphœdème du membre inferieur gauche surmontée de nodules angiomateux indolores évoluant depuis trois ans associé à des plaques, des nodules angiomateux d’apparition plus récente au niveau de la face antérieure du thorax. Le GeneXpert sur les crachats avait permis d’isoler Mycobacterium tuberculosis. Le diagnostic retenu était celui d’une tuberculose pulmonaire associée à une maladie de kaposi cutané sur un terrain d’immunodépression au VIH.

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Utilisation du test GeneXpert pour le diagnostic de la tuberculose au service des maladies infectieuses du CHNU de Fann

Cited by 9 publications

References 0 publications

Diagnostic accuracy of the Xpert MTB/RIF assay for tuberculous pericarditis: A systematic review and meta-analysis

Diagnostic accuracy of the Xpert MTB/RIF assay for tuberculous pericarditis: A systematic review and meta-analysis

Analysis of the Therapeutic Approach to Drug-Sensitive Tuberculosis in Morocco: Retrospective Study from 2014 to 2017

Co-infection Tuberculose/VIH et Maladie de kaposi sous traitement de substitution par la méthadone: à propos d’un cas

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