Utilité du dropéridol et de la diphenhydramine dans l’hyperemesis gravidarum

Turcotte, Virginie; Ferreira, Ema; Duperron, Louise

doi:10.1016/s0849-5831(16)30156-2

Cited by 2 publications

(2 citation statements)

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“…Unlike another trial, 17 our study assessed the severity of nausea and vomiting according to the NCI's "Common Toxicity Criteria" validated scale. 26,27 Although the investigated treatment showed a decrease in the intensity of nausea and vomiting, it is important to specify that the data from the control group were extracted from medical charts in a retrospective manner. A study comparing 2 concurrent and prospective groups with a random distribution would allow a more valid comparison of the efficacy of these 2 therapeutic regimens.…”

Section: Discussionmentioning

confidence: 99%

“…25 At Sainte-Justine Hospital, an established protocol consisting of a combination of droperidol and diphenhydramine has been used for the treatment of patients with HG since 1998. 26 The main objective of this study was to compare the efficacy of the droperidol/ diphenhydramine combination with that of other conventional treatments used before implementation of this protocol in the treatment of HG.…”

Section: 2122mentioning

confidence: 99%

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Case–Control Study Comparing Droperidol Plus Diphenhydramine with Conventional Treatment in Hyperemesis Gravidarum

Ferreira

Bussières

Turcotte

et al. 2003

Journal of Pharmacy Technology

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Nausea and vomiting occur frequently during the first trimester of pregnancy, affecting 50-70% of pregnant women. 1-4 A peak is observed between weeks 10 and 16 of gestation, and most symptoms disappear by the 20th week. 4-6 In 0.5-2% of pregnancies, nausea and vomiting are persistent and severe and are referred to as hyperemesis gravidarum (HG). 2,7 HG is diagnosed by the presence of weight loss ≥5% of prepregnancy weight, ketonuria, hypokalemia, dehydration, or nutritional deficiencies. 1,7 The etiology of HG is multifactorial, and HG may lead to maternal and fetal complications. 7-11 HG treatment must be provided quickly and aggressively to prevent complicaBackground: In 1998, a protocol consisting of droperidol/diphenhydramine combination was established at Hospital Sainte-Justine to treat hyperemesis gravidarum.

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Section: Discussionmentioning

confidence: 99%

Section: 2122mentioning

confidence: 99%