Utility and evaluation of biochemical markers of alcohol consumption

Rosman, Alan S.

doi:10.1016/0899-3289(92)90036-w

Cited by 26 publications

(13 citation statements)

References 91 publications

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“…30,31 In the study herein, there was no rigorous attempt to screen patients in either group for alcohol consumption. However, an elevation of a serum liver function test, gamma-glutamyl transpeptidase (GGT), has been employed as a sensitive indicator of liver enzyme induction and may be associated with alcohol consumption, 32,33 as well as other pharmacological agents, 34 or viral hepatitis, was available for analysis in both groups. With the limitations of such an analysis appreciated, one may extrapolate using Figure 1 Comparison of Serum HDL Cholesterol and Triglycerides Among the Ethnic Subgroups.…”

Section: Discussionmentioning

confidence: 99%

Is immobilization associated with an abnormal lipoprotein profile? Observations from a diverse cohort

et al. 1999

Spinal Cord

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Objective: The potential eects of ethnicity, gender, and adiposity on the serum lipid pro®le in persons with spinal cord injury (SCI) were determined. Subjects: Subjects with SCI were recruited during their annual physical examination from Rancho Los Amigos Medical Center, Downey, California. Sedentary able-bodied controls were Bridge and Tunnel Ocers of the Triboro Bridge and Tunnel Authority of the New York City metropolitan area. Methods: Serum lipid pro®les were investigated in 320 subjects with SCI and compared to those obtained from 303 relatively sedentary able-bodied controls. Serum lipid studies were obtained in the fasting state. Data were collected between 1993 and 1996. All lipid determinations were performed by the same commercial laboratory. Main outcome measures: The dependent variables were the values from the lipid pro®le analysis. The independent variables consisted of study group, gender, ethnic group, age, duration of injury, and anthropometric measurements. Results: The serum high-density lipoprotein cholesterol (HDL-c) level was reduced in the SCI compared with the control group (mean+SEM) (42+0.79 vs 47+0.67 mg/dl, P50.0005). The serum HDL-c level was signi®cantly lower in males with SCI than males in the control group (39+0.83 vs 45+0.70 mg/dl, P50.0001), but not for females (51+1.54 vs 54+1.52 mg/ dl, n.s.). Within the subgroups for whites and Latinos, HDL-c values were also lower in subjects with SCI than in controls (whites: 41+1.02 vs 46+0.86 mg/dl, P50.0001; Latinos: 37+1.53 vs 42+1.59 mg/dl, P50.05), but not for African Americans (49+1.56 vs 51+1.27 mg/dl, n.s.). African Americans had higher HDL-c values than whites or Latinos (SCI: 49+1.56 vs 41+1.02 or 37+1.53 mg/dl, P50.0001; controls: 51+1.27 vs 46+0.86 mg/ dl, P50.01 or 42+1.59 mg/dl, P50.0005). In persons with SCI, the serum HDL-c values were inversely related to body mass index and estimated per cent body fat (r=0.27, P50.0001). Conclusion: In white and Latino males, but not in females or African Americans, immobilization from SCI appears to be associated with lower HDL-c values than in controls.

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Section: Discussionmentioning

confidence: 99%

Is immobilization associated with an abnormal lipoprotein profile? Observations from a diverse cohort

et al. 1999

Spinal Cord

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“…Though, carbohydrate deficient transferring is more sensitive and specific than GGT in detecting relapse and recovery from alcohol use disorder but is more complex, costly and has long turnaround time than GGT [17]. The major limitation of GGT is that it is affected by liver disease of any cause and several medications including antiepileptic drugs and anticoagulants can give false positive result [18]. Diagnostic accuracy of GGT can be enhanced by combination with other traditional markers (AST, ALT, and MCV) [19].…”

Section: Discussionmentioning

confidence: 99%

Usefulness of Gamma Glutamyl Transferase as Reliable Biological Marker in Objective Corroboration of Relapse in Alcohol Dependent Patients

Dixit¹

2015

JCDR

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“…Screening for heavy drinkers is now facilitated by biological markers of excessive alcohol consumption. 237,238 Of the various markers studied, carbohydrate-deficient transferrin is particularly useful. 239,240 Because major complications (such as cirrhosis) do not develop in all heavy drinkers, there is a need for early detection of those susceptible individuals before their social or medical disintegration in order to prevent, rather than simply treat, their major somatic complications.…”

Section: Timing Of Therapymentioning

confidence: 99%

Metabolism of Ethanol and Some Associated Adverse Effects on the Liver and the Stomach

Lieber

Leo

1998

Recent Developments in Alcoholism

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Abstract. Current knowledge of alcohol oxidation and its effects on hepatic metabolism and its toxicity are summarized. This includes an evaluation of the relationship of the level of consumption to its interaction with nutrients (especially retinoids, carotenoids, and folate) and the development of various stages of liver disease. Ethanol metabolism in the stomach and its link to pathology and Helicobacter pylori is reviewed. Promising therapeutic approaches evolving from newly gained insight in the pathogenesis of medical complications of alcoholism are outlined. At present, the established approach for the prevention and treatment of alcoholic liver injury is to control alcohol abuse, with the judicial application of selective antioxidant therapy, instituted at early stages, prior to the social or medical disintegration of the patient, and associated with antiinflammatory agents at the acute phase of alcoholic hepatitis. In addition, effective antifibrotic therapy may soon become available.

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Utility and evaluation of biochemical markers of alcohol consumption

Cited by 26 publications

References 91 publications

Is immobilization associated with an abnormal lipoprotein profile? Observations from a diverse cohort

Is immobilization associated with an abnormal lipoprotein profile? Observations from a diverse cohort

Usefulness of Gamma Glutamyl Transferase as Reliable Biological Marker in Objective Corroboration of Relapse in Alcohol Dependent Patients

Metabolism of Ethanol and Some Associated Adverse Effects on the Liver and the Stomach

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