Utility of 19F MRS detection of the hypoxic cell marker EF5 to assess cellular hypoxia in solid tumors

Salmon, Howard W.; Siemann, Dietmar W.

doi:10.1016/j.radonc.2004.07.018

Cited by 27 publications

(9 citation statements)

References 30 publications

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“…Introducing several equivalent atoms of 19 F can enhance the signal-to-noise ratio still further. This approach to investigate hypoxia has been reported by several groups as reviewed previously (168)(169)(170)(171)(172)(173). However, the achievable signal-to-noise ratio is typically disappointing, usually requiring long data acquisition times and generally precluding imaging.…”

Section: Other Mr Methods For Imaging Hypoxiamentioning

confidence: 94%

Molecular Imaging of Hypoxia

2008

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Section: Other Mr Methods For Imaging Hypoxiamentioning

confidence: 94%

Molecular Imaging of Hypoxia

2008

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“…[12,[15][16][17]20] Prostate cancer Choline, citrate and creatine [12,16,17,19,39] Brain cancer N-acetyl-aspartate, creatine, lipids and choline [8,11,12,16,17] Cervical cancer Triglyceride, choline, creatine and lipids [9,24] Thyroid cancer Lysine and triaclglycerol [9] Tumoral metabolism-hypoxia Lactate and N-acetyl-aspartate [58] …”

Section: Resultsmentioning

confidence: 99%

“…In addition, diffusion of metabolites in normal and ischemic brain regions can be followed by localized 1 H-MRS. In neonatology practice, even though diffusion imaging is broadly utilized after perinatal asphyxia, it may underestimate the extent of the evolving cerebral hypoxic-ischemic injury; 1 H-MRS, on the other hand, may substantially help with its early diagnosis and with prognosis as well [58].…”

Section: Thyroid Cancermentioning

confidence: 99%

Magnetic resonance spectroscopy in cancer diagnostics

et al. 2010

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Magnetic resonance spectroscopy (MRS) is one of the most powerful analytical techniques, being frequently used to derive physical, chemical, electronic, and structural information about molecules. Considering its potentialities and its evolution as cell/tissue response predictor, it can be used to detect changes in the tumor pathophysiology before, during, and after treatment. Of particular relevance to this analysis, due to its higher sensitivity, is proton magnetic resonance spectroscopy ( 1 H-MRS) either applied directly in vivo or by using tumor biopsies and high-rotation magic angle spinning (HRMAS). Several metabolites have been quantified in several tumors, including creatine and phosphocreatine, choline, lactate and myoinositol, and used for distinguishing different cancer types. Several advantages characterize this technique including swiftness and ability to support the characterization of tumoral lesions on the basis of their biochemical composition, which may provide additional diagnostic and prognostic information as an adjunct to routine histological assessment. Many tumors have already been studied by 1 H-MRS, and there is growing interest in studying others in order to establish extended metabolite databases which could help in their identification and characterization.

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“…Some of the markers gaining acceptance in this group are hexafluoromisonidazole (CCI-103F) [77], EF-5 [78], and SR-4554 [79,80]. SR-4554 has shown good results and is now under phase-I trial for in vivo detection of tumor hypoxia [81].…”

Section: Magnetic Resonance (Mr) Techniquesmentioning

confidence: 99%

Advances in methods for assessing tumor hypoxia in vivo: Implications for treatment planning

Davda

Bezabeh

2006

Cancer Metastasis Rev

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Tumor hypoxia and its downstream effects have remained of considerable interest for decades due to its negative impact on response to various cancer therapies and promotion of metastasis. Diagnosing hypoxia non-invasively can provide a significant advancement in cancer treatment and is the dire necessity for implementing specific targeted therapies now emerging to treat different aspects of cancer. A variety of techniques are being proposed to do so. However, none of them has yet been established in the clinical arena. This review summarizes the methods currently available to assess tumor hypoxia in vivo and their respective advantages and shortcomings. It also points out the impedances that need to be overcome to establish any particular method in the clinic, along with a broad overview of requirements for further advancement in this sphere of cancer research.

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Utility of 19F MRS detection of the hypoxic cell marker EF5 to assess cellular hypoxia in solid tumors

Cited by 27 publications

References 30 publications

Molecular Imaging of Hypoxia

Molecular Imaging of Hypoxia

Magnetic resonance spectroscopy in cancer diagnostics

Advances in methods for assessing tumor hypoxia in vivo: Implications for treatment planning

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