Utility of Additional Tissue Sections in Surgical Pathology

Hamza, Ameer; Alrajjal, Ahmed; Edens, Jacob; Khawar, Sidrah; Khurram, Muhammad; Szpunar, Susanna; Bonnett, Michelle

doi:10.1177/1066896918755008

Cited by 11 publications

(9 citation statements)

References 57 publications

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“…A recent study found upstaging of pT stage in 7 of 53 cases when the entire tumor bed was submitted. 28 In our study, 9.2% patients received neoadjuvant therapy. Among these 47.4% cases had concordant size compared with 56.8% cases, where the patients did not receive neoadjuvant therapy; however, this difference was not statistically significant (P = .26).…”

Section: Discussionmentioning

confidence: 63%

Tumor Size in Breast Carcinoma: Gross Measurement Is Important!

et al. 2018

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Section: Discussionmentioning

confidence: 63%

Tumor Size in Breast Carcinoma: Gross Measurement Is Important!

et al. 2018

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“…The main core of diagnosis of UPS is to exclude other malignant tumors that display similar morphological findings such as malignant melanomas, sarcomatoid carcinomas, anaplastic lymphomas, sarcomatoid mesotheliomas, or other sarcomas (e.g., dedifferentiated liposarcoma and pleomorphic rhabdomyosarcoma, etc.). Therefore, it is a diagnosis of exclusion, which requires careful examination of tissue and generous sampling of the specimen to stablish a correct diagnosis 12. This diagnosis should not be made definitively on a biopsy specimen, because the entire mass is not present in the biopsy materials.…”

Section: Discussionmentioning

confidence: 99%

Primary pulmonary undifferentiated pleomorphic sarcoma (PPUPS)

Qorbani

Nelson

2019

Autops. Case Rep.

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Undifferentiated pleomorphic sarcoma (UPS) is a high-grade pleomorphic neoplasm with no identifiable line(s) of differentiation using currently available diagnostic techniques. Therefore, it is essentially a diagnosis of exclusion, which requires generous tissue sampling, adequate contextually interpreted immunohistochemistry, and relevant molecular studies. UPS is a common soft tissue sarcoma (historically one of the entities referred to as malignant fibrous histiocytoma (MFH)), which can develop in various organs, but lung involvement is usually due to metastasis. Primary Pulmonary UPS (PPUPS) is exceptionally rare and here we present a 66-year-old man who presented with anemia and weight loss, found to have a 17 cm right lung mass with invasion to the chest wall and diaphragm. Extensive sampling and immunohistochemistry studies failed to reveal any line of differentiation. Upon exclusion of a possible extrapulmonary origin, a diagnosis of PPUPS was rendered. In addition, we reviewed all 84 previously reported cases of PPUPS/PPMFH in the literature since 1979 and summarized the clinical information.

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“…28,47-49 Finally, it is important to emphasize that thorough tissue sampling is extremely invaluable in reaching the correct diagnosis. 50,51…”

Section: Discussionmentioning

confidence: 99%

Perivascular Epithelioid Cell Tumor of the Urinary Bladder: A Systematic Review

Hamza

Guo

2019

Int J Surg Pathol

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Perivascular epithelioid cell tumor (PEComa) of the urinary bladder is a rare neoplasm showing distinct melanocytic and smooth muscle differentiation. We aimed to review the clinicopathologic features of bladder PEComa using all the available cases in the literature, along with 2 new cases from our database. The patients included 15 females and 15 males with a mean age of 39.2 ± 15.3 years. Painless hematuria was the most common clinical presentation. The tumors were usually well circumscribed with a mean tumor size of 4.4 ± 2.7 cm. Bladder PEComas demonstrated nests, trabeculae, or sheets of epithelioid cells with intermixed spindled cells and numerous thin-walled vessels. Immunohistochemical studies showed that the tumors were positive for HMB45 (27/27), cathepsin (4/4), SMA (20/22), and caldesmon (3/3) and were negative for pan cytokeratin (0/18) and EMA (0/4). Molecular studies revealed that PEComa was associated with the TFE3 (n = 3) and EWSR1 (n = 1) gene rearrangements. Treatment included partial cystectomy (n = 18), transurethral resection (n = 8), and radical cystectomy (n = 4). Twenty patients had no evidence of disease during a mean follow-up time of 19.4 ± 17.2 months. Two patients had recurrence, and 1 patient died of metastatic disease. In conclusion, bladder PEComas demonstrate distinct morphologic and immunohistochemical features. Although most tumors follow a benign course, a small subset may develop metastasis and cause death.

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Utility of Additional Tissue Sections in Surgical Pathology

Cited by 11 publications

References 57 publications

Tumor Size in Breast Carcinoma: Gross Measurement Is Important!

Tumor Size in Breast Carcinoma: Gross Measurement Is Important!

Primary pulmonary undifferentiated pleomorphic sarcoma (PPUPS)

Perivascular Epithelioid Cell Tumor of the Urinary Bladder: A Systematic Review

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