Utility of Prostate Specific Antigen in the Diagnosis of Various Prostatic Lesions

Abstract

BACKGROUNDCarcinoma of the prostate is the most common internal malignancy among men in the United States and 10 th common malignancy in India. It accounts for 33% of all malignant tumours in men and responsible for 9% of all deaths due to cancer. Prostate specific antigen (PSA), a glycoprotein serine protease, was first identified by Wang et al in 1979. Prostate specific antigen (PSA) is a substance produced exclusively by certain cells within the male prostate gland. PSA is the most useful tumour marker in diagnosis and first line test in screening.The aims of this study were-1. To evaluate the utility of PSA assay as a method of investigation in diagnosis of prostatic lesions. 2. To correlate morphological types with serum PSA levels.