Utility of Step Sections

Carag, Henry R.; Prieto, Víctor G.; Yballe, Liza S.; Shea, Christopher R.

doi:10.1001/archderm.136.4.471

Cited by 36 publications

(13 citation statements)

References 22 publications

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“…Evolution towards malignancy can lead to the appearance of malignant melanoma, 6,7 squamous cell carcinoma, 8–10 keratoacanthoma, 11 basal cell carcinoma, 6,12–14 Bowen’s disease, 15 intraepithelial epithelioma 16 and eccrine porocarcinoma 17 . These findings correspond generally with those of our study where some lesions with a clinical picture of seborrhoeic keratosis histopathologically proved to be basal or squamous cell carcinomas, actinic keratoses, malignant melanomas, lesions of Bowen’s disease or eccrine poromas.…”

Section: Discussionsupporting

confidence: 90%

“…Many authors accept the rare coexistence of skin malignancy with seborrhoeic keratosis despite the fact that the latter is quite common in the general population. 6 Evolution towards malignancy can lead to the appearance of malignant melanoma, 6,7 squamous cell carcinoma, [8][9][10] fig. 2 Histopathological picture of an adenoid basal cell carcinoma with overlying-adjacent seborrhoeic keratosis (haematoxylin and eosin, original magnification × 40).…”

Section: Discussionmentioning

confidence: 99%

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Seborrhoeic keratosis or occult malignant neoplasm of the skin?

Rigopoulos

Rallis²,

Toumbis-Ioannou³

et al. 2002

Acad Dermatol Venereol

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Seborrhoeic keratosis or occult malignant neoplasm of the skin?

Rigopoulos

Rallis²,

Toumbis-Ioannou³

et al. 2002

Acad Dermatol Venereol

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“…increase diagnostic accuracy in about one third of skin biopsies. 2,3 Similar increases have also been noted on small skin biopsy specimens. 2,4 However, some of these studies used a large number of step sections and focussed on only particular disease entities.…”

supporting

confidence: 71%

Utility of prospective step sections in diagnostic skin histopathology for small biopsies

2014

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Background: Small skin biopsies have a cosmetic advantage and prospective step sections could potentially improve turnaround time without compromising diagnostic information. The study aimed to examine the use of prospective step sections of small skin biopsies and its effect on histopathological diagnosis and turnaround time. Materials and Methods: This was a hospital based cross-sectional study at Department of Pathology and Department of Dermatology, BPKIHS from June 2011- June 2012. Diagnoses /comment on three levels of prospectively taken 3mm biopsies were compared with those of 5mm biopsies taken from the same/similar lesion from 100 patients. Additional sections from 5mm biopsies were taken retrospectively. Percentage, proportion, mean, standard deviation, diagnostic sensitivity, kappa statistics and paired sample t- test were used as statistical tools. Results: Of 100 cases, 80 were diagnosed using 5mm biopsies while 73 were diagnosed using 3mm biopsies. On additional step sections of 3mm biopsies, 3 more cases were diagnosed. When compared with 5mm biopsies, the sensitivity of the 3mm biopsy rose from 90% to 93.8% after additional sections while the measure of agreement rose from 0.751 to 0.826.Mean turnaround time for prospectively sectioned 3mm biopsies was 2.56 days and that of retrospectively sectioned 5 mm biopsies was 4.64 days with their difference being statistically significant. Conclusion: A statistically significant decrease in turnaround time and an increase in sensitivity and agreement after step sections elucidates the utility of prospective step sectioned 3 mm biopsies in diagnostic skin histopathology. DOI: http://dx.doi.org/10.3126/jpn.v4i7.10298 Journal of Pathology of Nepal (2014) Vol. 4, 552-559

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“…This observation is crucial due to the association between lesion size and SCC development. Two histological studies demonstrated that AK progression to SCC is not a rare event 26,27. Ehrig et al biopsied 220 AK lesions and Carag et al 69 AK lesions, and reported 3.2% and 13% of these lesions to be SCC in situ, while 1.4% and 3% of lesions were invasive SCC 26,27.…”

Section: Discussionmentioning

confidence: 99%

A randomized, double-blind, placebo-controlled clinical trial evaluating Dermytol® cream for the treatment of actinic keratoses

Evans¹,

Álvarez²,

Paquet³

et al. 2014

CCID

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PurposeActinic keratosis lesions (AKs) have the potential to develop into squamous cell carcinoma (SCC) and thus therapies to prevent SCC development from AKs are warranted. The aim of this study was to assess the effects of a 3 month application of a canola phenolic acid-based cream (CPA) on AK lesions.Patients and methodsThis was a randomized, double-blind, placebo-controlled, 12 week clinical study conducted at a single-center in Santo Domingo, Dominican Republic. Forty-five subjects (30 CPA and 15 placebo), aged 45–85 years with 3–10 AKs within a 20 cm2 treatment area (scalp, forehead, dorsal forearm, neck, or back of hand) were enrolled. The primary outcome was complete or partial lesion clearance and the secondary outcome was safety of CPA.ResultsAlthough complete AK lesion clearance was not seen in this study, a significant reduction in the mean change from baseline in the average lesion area was observed at weeks 3 (P=0.002), 6 (P<0.001), and 12 (P<0.001) in the CPA group, but only at weeks 6 and 12 in the placebo group (P=0.005 and P=0.002, respectively). Furthermore, the proportion of participants with a $10% decrease in average lesion area was significantly higher in the CPA group than the placebo group at weeks 3 (P=0.05) and 6 (P=0.02), and showed a trend at week 12 (P=0.06). A subset analysis of the change in average lesion area based upon the total lesion area at baseline revealed that CPA elicited a greater reduction than placebo (2×) in participants with a baseline total AK lesion area of 100–500 mm2 than in participants with a total area <100 mm2 (1.3×).ConclusionThe results of this study and previous in vitro studies suggest a potential role for CPA in the treatment of AK lesions and the prevention of SCC development.

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Utility of Step Sections

Cited by 36 publications

References 22 publications

Seborrhoeic keratosis or occult malignant neoplasm of the skin?

Seborrhoeic keratosis or occult malignant neoplasm of the skin?

Utility of prospective step sections in diagnostic skin histopathology for small biopsies

A randomized, double-blind, placebo-controlled clinical trial evaluating Dermytol® cream for the treatment of actinic keratoses

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Utility of Step Sections

Cited by 36 publications

References 22 publications

Seborrhoeic keratosis or occult malignant neoplasm of the skin?

Seborrhoeic keratosis or occult malignant neoplasm of the skin?

Utility of prospective step sections in diagnostic skin histopathology for small biopsies

A randomized, double-blind, placebo-controlled clinical trial evaluating Dermytol&reg; cream for the treatment of actinic keratoses

Contact Info

Product

Resources

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A randomized, double-blind, placebo-controlled clinical trial evaluating Dermytol® cream for the treatment of actinic keratoses