2009
DOI: 10.1590/s0100-40422009000200031
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Utilização do D-manitol em síntese orgânica

Abstract: Recebido em 25/4/08; aceito em 25/7/08; publicado na web em 20/1/09 D-MaNNITOl IN ORgaNIC SyNTheSIS. D-mannitol is used in several fields including food, pharmaceuticals, cosmetics and textiles being an important carbohydrate found widespread in nature. Due to its chirality, it is largely used in organic synthesis with several applications, such as ligands, polymers, chiral pool, for preparation of small chiral building blocks, key intermediates in total synthesis. In this context, the aim of this review is to… Show more

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Cited by 11 publications
(10 citation statements)
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“…Due to its sweetener characteristic, mannitol becomes very attractive from the point of view of food industry, because it is a dietary carbohydrate that has reduced caloric value, since it is only partially absorbed in the small intestine. In fact, this alcohol-sugar derivative finds important applications in pharmaceutical, cosmetic and food industries (Oliveira, Ferreira, & Souza, 2009). …”
Section: Resultsmentioning
confidence: 99%
“…Due to its sweetener characteristic, mannitol becomes very attractive from the point of view of food industry, because it is a dietary carbohydrate that has reduced caloric value, since it is only partially absorbed in the small intestine. In fact, this alcohol-sugar derivative finds important applications in pharmaceutical, cosmetic and food industries (Oliveira, Ferreira, & Souza, 2009). …”
Section: Resultsmentioning
confidence: 99%
“…24,25 O D-manitol é obtido industrialmente de uma mistura D-Sorbitol/D-manitol, a qual é obtida a partir de hidrólise ácida de D-Sacarose, seguida de hidrogenação catalítica. 25 Isopropilideno quiral 3 e seus derivados 4-6 são obtidos pela redução de 2, e posterior manipulação do grupo hidroxila livre de 3. Esta série de compostos com configuração oposta é obtida a partir de L-serina ou ácido ascórbico.…”
Section: Glicerol Em Sínteses Estereosseletivasunclassified
“…138 Algumas destas aplicações estão resumidas no esquema 21. Na indústria farmacêutica, é usado como excipiente em comprimidos, especialmente aqueles destinados a dissolverem-se na boca, devido à agradável sensação de doçura e frescor mencionados anteriormente.…”
Section: D-manitolunclassified