Utilization of nanoparticles in microfluidic systems for optical detection

Liang, Wenbin; Lin, Hangyu; Chen, Junfang; Chen, Chuanpin

doi:10.1007/s00542-016-2921-4

Cited by 15 publications

(7 citation statements)

References 55 publications

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“…Research on rapid tests has developed considerably, especially regarding nanoparticles-based devices [ 168 ] and microfluidics [ 169 ], paving the way to the emergence of new diagnostic devices [ 170 ]. Wearable chemical sensors enabling real-time on-body analytical chemistry are in increasing development.…”

Section: Alternative Tools To Mass Spectrometry and Nuclear Magnetic Resonance Instruments For Making Metabolomics Valuable In Clinical Lmentioning

confidence: 99%

“…This is especially of interest for small molecules for which antibodies are not well suited. However, their implementation into PoC nanobiosensors is rather scarce [ 169 ], and despite promising results, there is still no commercialized diagnostic tests based on aptamers. Studies are needed to evaluate their performance in biological media for diagnostic tests involving metabolites.…”

Section: Alternative Tools To Mass Spectrometry and Nuclear Magnetic Resonance Instruments For Making Metabolomics Valuable In Clinical Lmentioning

confidence: 99%

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Metabolomics for personalized medicine: the input of analytical chemistry from biomarker discovery to point-of-care tests

et al. 2021

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Metabolomics refers to the large-scale detection, quantification, and analysis of small molecules (metabolites) in biological media. Although metabolomics, alone or combined with other omics data, has already demonstrated its relevance for patient stratification in the frame of research projects and clinical studies, much remains to be done to move this approach to the clinical practice. This is especially true in the perspective of being applied to personalized/precision medicine, which aims at stratifying patients according to their risk of developing diseases, and tailoring medical treatments of patients according to individual characteristics in order to improve their efficacy and limit their toxicity. In this review article, we discuss the main challenges linked to analytical chemistry that need to be addressed to foster the implementation of metabolomics in the clinics and the use of the data produced by this approach in personalized medicine. First of all, there are already well-known issues related to untargeted metabolomics workflows at the levels of data production (lack of standardization), metabolite identification (small proportion of annotated features and identified metabolites), and data processing (from automatic detection of features to multi-omic data integration) that hamper the inter-operability and reusability of metabolomics data. Furthermore, the outputs of metabolomics workflows are complex molecular signatures of few tens of metabolites, often with small abundance variations, and obtained with expensive laboratory equipment. It is thus necessary to simplify these molecular signatures so that they can be produced and used in the field. This last point, which is still poorly addressed by the metabolomics community, may be crucial in a near future with the increased availability of molecular signatures of medical relevance and the increased societal demand for participatory medicine. Graphical abstract

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Section: Alternative Tools To Mass Spectrometry and Nuclear Magnetic Resonance Instruments For Making Metabolomics Valuable In Clinical Lmentioning

confidence: 99%

Section: Alternative Tools To Mass Spectrometry and Nuclear Magnetic Resonance Instruments For Making Metabolomics Valuable In Clinical Lmentioning

confidence: 99%

Metabolomics for personalized medicine: the input of analytical chemistry from biomarker discovery to point-of-care tests

et al. 2021

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“…Electrochemical detection has become a popular detection mode in MF due to its small size, high sensitivity, and selectivity. It is particularly used in portable MF devices on the microchip platform [ 89 , 90 ]. These simple, easy-to-use and sensitive analytical tools are essential for on-site detection of variable analytes in complex samples (such as food, feed, biological or environmental matrices) [ 91 , 92 ].…”

Section: Fundamentals Of Microfluidicsmentioning

confidence: 99%

Microfluidics for Peptidomics, Proteomics, and Cell Analysis

et al. 2021

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Microfluidics is the advanced microtechnology of fluid manipulation in channels with at least one dimension in the range of 1–100 microns. Microfluidic technology offers a growing number of tools for manipulating small volumes of fluid to control chemical, biological, and physical processes relevant to separation, analysis, and detection. Currently, microfluidic devices play an important role in many biological, chemical, physical, biotechnological and engineering applications. There are numerous ways to fabricate the necessary microchannels and integrate them into microfluidic platforms. In peptidomics and proteomics, microfluidics is often used in combination with mass spectrometric (MS) analysis. This review provides an overview of using microfluidic systems for peptidomics, proteomics and cell analysis. The application of microfluidics in combination with MS detection and other novel techniques to answer clinical questions is also discussed in the context of disease diagnosis and therapy. Recent developments and applications of capillary and microchip (electro)separation methods in proteomic and peptidomic analysis are summarized. The state of the art of microchip platforms for cell sorting and single-cell analysis is also discussed. Advances in detection methods are reported, and new applications in proteomics and peptidomics, quality control of peptide and protein pharmaceuticals, analysis of proteins and peptides in biomatrices and determination of their physicochemical parameters are highlighted.

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“…Firstly, the small dimensions of the detection channel enable lower reagent consumption and minimised waste production in comparison to conventional methods [53,54]. Secondly, the high ratio between surface area and volume along with the short diffusion distance enables fast reaction times [55]. Thirdly, miniaturised onsite analysis of samples also reduces contamination risk during sample handling and transportation.…”

Section: Americasmentioning

confidence: 99%

A Review of Microfluidic Detection Strategies for Heavy Metals in Water

Lace

Cleary

2021

Chemosensors

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Heavy metal pollution of water has become a global issue and is especially problematic in some developing countries. Heavy metals are toxic to living organisms, even at very low concentrations. Therefore, effective and reliable heavy metal detection in environmental water is very important. Current laboratory-based methods used for analysis of heavy metals in water require sophisticated instrumentation and highly trained technicians, making them unsuitable for routine heavy metal monitoring in the environment. Consequently, there is a growing demand for autonomous detection systems that could perform in situ or point-of-use measurements. Microfluidic detection systems, which are defined by their small size, have many characteristics that make them suitable for environmental analysis. Some of these advantages include portability, high sample throughput, reduced reagent consumption and waste generation, and reduced production cost. This review focusses on developments in the application of microfluidic detection systems to heavy metal detection in water. Microfluidic detection strategies based on optical techniques, electrochemical techniques, and quartz crystal microbalance are discussed.

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Utilization of nanoparticles in microfluidic systems for optical detection

Cited by 15 publications

References 55 publications

Metabolomics for personalized medicine: the input of analytical chemistry from biomarker discovery to point-of-care tests

Metabolomics for personalized medicine: the input of analytical chemistry from biomarker discovery to point-of-care tests

Microfluidics for Peptidomics, Proteomics, and Cell Analysis

A Review of Microfluidic Detection Strategies for Heavy Metals in Water

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