Utilization of the Buccal Fat Pad Flap for Congenital Cleft Palate Repair

Lévi, Benjamin; Kasten, Steven J.; Buchman, Steven R.

doi:10.1097/prs.0b013e318199f80f

Cited by 68 publications

(72 citation statements)

References 16 publications

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“…The transferred BFP was fully epithelialized with healthylooking oral mucosa within 4 weeks, regardless of graft coverage with palatal mucosa or not. The limitations in the size of the defect are similar to previous studies 13 . The maximum size of the defects encountered was 2 cm Â 2 cm Â 1 cm.…”

Section: Discussionsupporting

confidence: 66%

“…In 1983, NEDER 15 investigated the use of the BFP as a free graft in the reconstruction of palatal defects and TIDE-MAN et al 26 successfully employed BFP for the correction of buccal and maxillary defects in 1986. Little has been published about the use of BFP in cleft palate surgery since HUDSON et al 11 reported on the use of BFP as an adjunct in palatal cleft defects in The use of buccal fat pad (BFP) as a pedicled graft 687 13 .…”

Section: Discussionmentioning

confidence: 99%

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The use of buccal fat pad (BFP) as a pedicled graft in cleft palate surgery

Gröbe

Eichhorn²,

Hanken

et al. 2011

International Journal of Oral and Maxillofacial Surgery

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

The use of buccal fat pad (BFP) as a pedicled graft in cleft palate surgery

Gröbe

Eichhorn²,

Hanken

et al. 2011

International Journal of Oral and Maxillofacial Surgery

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“…Since 1977, the BFP has been used in surgery for the treatment of congenital oroantral and/or oronasal diseases [15], congenital cleft palate repair [16], oral submucous fibrosis [17,18], intraoral malignant defects [19], and cheek mucosa defects [15,20]. In addition, BFP is a discarded tissue of plastic surgery for cheek reduction.…”

Section: Introductionmentioning

confidence: 99%

Porcine adipose-derived stem cells from buccal fat pad and subcutaneous adipose tissue for future preclinical studies in oral surgery

et al. 2013

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IntroductionAdipose-derived stem cells (ASCs) are progenitor cells used in bone tissue engineering and regenerative medicine. Despite subcutaneous adipose tissue being more abundant, the buccal fat pad (BFP) is easily accessible for dentists and maxillofacial surgeons. For this reason, considering the need for preclinical study and the swine as an optimal animal model in tissue engineering applications, we compared the features of porcine ASCs (pASCs) from both tissue-harvesting sites.MethodsASCs were isolated from interscapular subcutaneous adipose tissue (ScI) and buccal fat pads of six swine. Cells were characterized for their stemness and multipotent features. Moreover, their osteogenic ability when cultured on titanium disks and silicon carbide-plasma-enhanced chemical vapor-deposition fragments, and their growth in the presence of autologous and heterologous serum were also assessed.ResultsIndependent of the harvesting site, no differences in proliferation, viability, and clonogenicity were observed among all the pASC populations. Furthermore, when induced toward osteogenic differentiation, both ScI- and BFP-pASCs showed an increase of collagen and calcified extracellular matrix (ECM) production, alkaline phosphatase activity, and osteonectin expression, indicating their ability to differentiate toward osteoblast-like cells. In addition, they differentiated toward adipocyte-like cells, and chondrogenic induced pASCs were able to increase glycosaminoglycans (GAGs) production over time. When cells were osteoinduced on synthetic biomaterials, they significantly increased the amount of calcified ECM compared with control cells; moreover, titanium showed the osteoinductive effect on pASCs, also without chemical stimuli. Finally, these cells grew nicely in 10% FBS, and no benefits were produced by substitution with swine serum.ConclusionsSwine buccal fat pad contains progenitor cells with mesenchymal features, and they also osteo-differentiate nicely in association with synthetic supports. We suggest that porcine BFP-ASCs may be applied in preclinical studies of periodontal and bone-defect regeneration.

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“…61,62 More recently, buccal fat has also been employed to cover laterally exposed bone adjacent to gingival mucosa following medialization of the mucoperiosteal flaps. 63 As this was found to re-epithelialize within two weeks, use of the buccal fat pad may result in an eventual reduction of palatal scarring, which may limit subsequent growth restriction of the maxilla. And in similar fashion to AlloDerm, the buccal fat pad has also been shown to be effective as an interpositional layer between oral and nasal lining in the repair of postoperative fistulas.…”

Section: Clinical Implications and Potential Therapiesmentioning

confidence: 98%

“…And in similar fashion to AlloDerm, the buccal fat pad has also been shown to be effective as an interpositional layer between oral and nasal lining in the repair of postoperative fistulas. 63 Fuimora et al have even evaluated the utility of combining the two, with the successful treatment of oronasal fistulas using pedicled buccal fat covered with lyophilized dermis in adult patients. 64…”

Section: Clinical Implications and Potential Therapiesmentioning

confidence: 98%

Palatogenesis

et al. 2011

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Cleft palate represents the second most common birth defect and carries substantial physiologic and social challenges for affected patients, as they often require multiple surgical interventions during their lifetime. A number of genes have been identified to be associated with the cleft palate phenotype, but etiology in the majority of cases remains elusive. In order to better understand cleft palate and both surgical and potential tissue engineering approaches for repair, we have performed an in-depth literature review into cleft palate development in humans and mice, as well as into molecular pathways underlying these pathologic developments. We summarize the multitude of pathways underlying cleft palate development, with the transforming growth factor beta superfamily being the most commonly studied. Furthermore, while the majority of cleft palate studies are performed using a mouse model, studies focusing on tissue engineering have also focused heavily on mouse models. A paucity of human randomized controlled studies exists for cleft palate repair, and so far, tissue engineering approaches are limited. In this review, we discuss the development of the palate, explain the basic science behind normal and pathologic palate development in humans as well as mouse models and elaborate on how these studies may lead to future advances in palatal tissue engineering and cleft palate treatments.

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Utilization of the Buccal Fat Pad Flap for Congenital Cleft Palate Repair

Cited by 68 publications

References 16 publications

The use of buccal fat pad (BFP) as a pedicled graft in cleft palate surgery

The use of buccal fat pad (BFP) as a pedicled graft in cleft palate surgery

Porcine adipose-derived stem cells from buccal fat pad and subcutaneous adipose tissue for future preclinical studies in oral surgery

Palatogenesis

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