Utilizing 4D Printing to Design Smart Gastroretentive, Esophageal, and Intravesical Drug Delivery Systems

Mahmoud, Dina B.; Schulz‐Siegmund, Michaela

doi:10.1002/adhm.202202631

Cited by 27 publications

(10 citation statements)

References 215 publications

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“…4D printing is applied in numerous advanced drug delivery systems to improve efficiency in treatment outcomes. Controlled release of drugs, patient-specific dosing, and targeted delivery are the main advantages of these 4D printed structures compared to conventional systems [57]. Researchers can fabricate devices that release drugs at a precise rate over a predetermined period by utilizing the ability of the 4D printed scaffolds/structures to respond to specific stimuli like temperature and pH changes [58].…”

Section: D Printingmentioning

confidence: 99%

3D and 4D printing of biomedical materials: current trends, challenges, and future outlook

Appuhamillage,

Ambagaspitiya,

Dassanayake

et al. 2024

Exploration of Medicine

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Three-dimensional (3D) and four-dimensional (4D) printing have emerged as the next-generation fabrication technologies, covering a broad spectrum of areas, including construction, medicine, transportation, and textiles. 3D printing, also known as additive manufacturing (AM), allows the fabrication of complex structures with high precision via a layer-by-layer addition of various materials. On the other hand, 4D printing technology enables printing smart materials that can alter their shape, properties, and functions upon a stimulus, such as solvent, radiation, heat, pH, magnetism, current, pressure, and relative humidity (RH). Myriad of biomedical materials (BMMs) currently serve in many biomedical engineering fields aiding patients’ needs and expanding their life-span. 3D printing of BMMs provides geometries that are impossible via conventional processing techniques, while 4D printing yields dynamic BMMs, which are intended to be in long-term contact with biological systems owing to their time-dependent stimuli responsiveness. This review comprehensively covers the most recent technological advances in 3D and 4D printing towards fabricating BMMs for tissue engineering, drug delivery, surgical and diagnostic tools, and implants and prosthetics. In addition, the challenges and gaps of 3D and 4D printed BMMs, along with their future outlook, are also extensively discussed. The current review also addresses the scarcity in the literature on the composition, properties, and performances of 3D and 4D printed BMMs in medical applications and their pros and cons. Moreover, the content presented would be immensely beneficial for material scientists, chemists, and engineers engaged in AM manufacturing and clinicians in the biomedical field. Graphical abstract. 3D and 4D printing towards biomedical applications

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Section: D Printingmentioning

confidence: 99%

3D and 4D printing of biomedical materials: current trends, challenges, and future outlook

Appuhamillage,

Ambagaspitiya,

Dassanayake

et al. 2024

Exploration of Medicine

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show abstract

“…This issue can be solved by designing intelligent polymer chains or deformable devices through 3D printing. [493][494][495][496] This approach helps a drug-loaded stimuliresponsive capsule release the medicine in a controlled manner under a specific stimulus at a specified body location. [497][498][499] Unlike traditional manufacturing methods, 3D printing is highly advantageous to develop personalized, made-on-demand, and unprecedented complex structures, which enhance the effectiveness, accessibility, and safety of drugs.…”

Section: Biomedical Sectormentioning

confidence: 99%

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Tariq,

Arif,

Khalid

et al. 2023

Adv Eng Mater

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Stimuli‐responsive polymers (SRPs) are special types of soft materials, which have been extensively used for developing flexible actuators, soft robots, wearable devices, sensors, self‐expanding structures, and biomedical devices, thanks to their ability to change their shapes and functional properties in response to external stimuli including light, humidity, heat, pH, electric field, solvent, and magnetic field or combinations of two or more of these stimuli. In recent years, additive manufacturing (AM) aka three‐dimensional (3D) printing technology of these SRPs, also known as four‐dimensional (4D) printing, has gained phenomenal attention in different engineering fields, thanks to its unique ability to develop complex, personalized, and innovative structures, which undergo twisting, elongating, swelling, rolling, shrinking, bending, spiraling, and other complex morphological transformations. Herein, an effort has been made to provide insightful information about the AM techniques, type of SRPs, and their applications including, but not limited to tissue engineering, soft robots, bionics, actuators, sensors, construction, and smart textiles. This article also incorporates the current challenges and prospects, hoping to provide an insightful basis for the utilization of this technology in different engineering fields. It is expected that the amalgamation of 3D printing with SRPs would provide unparalleled advantages in different engineering arenas.This article is protected by copyright. All rights reserved.

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“…Other examples were represented by 4D-printed drug-eluting stents that could release medications gradually to prevent restenosis in blood vessels [121].…”

Section: Drug Deliverymentioning

confidence: 99%

4D Printing Shape-Morphing Hybrid Biomaterials for Advanced Bioengineering Applications

Chiesa,

Ceccarini,

Bittolo Bon

et al. 2023

Materials

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Four-dimensional (4D) printing is an innovative additive manufacturing technology used to fabricate structures that can evolve over time when exposed to a predefined environmental stimulus. 4D printed objects are no longer static objects but programmable active structures that accomplish their functions thanks to a change over time in their physical/chemical properties that usually displays macroscopically as a shapeshifting in response to an external stimulus. 4D printing is characterized by several entangled features (e.g., involved material(s), structure geometry, and applied stimulus entities) that need to be carefully coupled to obtain a favorable fabrication and a functioning structure. Overall, the integration of micro-/nanofabrication methods of biomaterials with nanomaterials represents a promising approach for the development of advanced materials. The ability to construct complex and multifunctional triggerable structures capable of being activated allows for the control of biomedical device activity, reducing the need for invasive interventions. Such advancements provide new tools to biomedical engineers and clinicians to design dynamically actuated implantable devices. In this context, the aim of this review is to demonstrate the potential of 4D printing as an enabling manufacturing technology to code the environmentally triggered physical evolution of structures and devices of biomedical interest.

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Utilizing 4D Printing to Design Smart Gastroretentive, Esophageal, and Intravesical Drug Delivery Systems

Cited by 27 publications

References 215 publications

3D and 4D printing of biomedical materials: current trends, challenges, and future outlook

3D and 4D printing of biomedical materials: current trends, challenges, and future outlook

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

4D Printing Shape-Morphing Hybrid Biomaterials for Advanced Bioengineering Applications

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