Utilizing Granulocyte Colony—stimulating Factor to Enhance Vascular Graft Endothelialization from Circulating Blood Cells

Shi, Qun; Bhattacharya, Vishwanath; Wu, Moses Hong-De; Sauvage, Lester R.

doi:10.1007/s10016-001-0238-x

Cited by 61 publications

(48 citation statements)

References 30 publications

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“…Tissue ischemia is presumed to be the strongest stimulus for EPC mobilization from the BM to the circulation (14,17). Moreover, EPC mobilization can be augmented by various cytokines, including G-CSF, GM-CSF VEGF, and placental growth factor (15,(21)(22)(23). Wounding increased the number of circulating EPCs to a similar extent in WT and Ccr5 -/-mice.…”

Section: Discussionmentioning

confidence: 99%

Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing

Ishida¹,

Kimura²,

Kuninaka³

et al. 2012

J. Clin. Invest.

140

125

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Section: Discussionmentioning

confidence: 99%

Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing

Ishida¹,

Kimura²,

Kuninaka³

et al. 2012

J. Clin. Invest.

140

125

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“…Bhattacharya et al 101 and Shi et al 102 reported that mobilization of bone marrow by exogenous G-CSF enhanced endothelialization and patency of small caliber prosthetic grafts. We showed that treatment with G-CSF before balloon injury of rat carotid arteries led to accelerated re-endothelialization and concomitant reduction in neointima of the injured vessels, in association with an increase in the number of CEPCs.…”

Section: Endothelial Cell Therapy For Vascular Repair and Bioengineermentioning

confidence: 99%

Therapeutic Potential of Endothelial Progenitor Cells in Cardiovascular Diseases

et al. 2005

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Abstract-Endothelial dysfunction and cell loss are prominent features in cardiovascular disease. Endothelial progenitor cells (EPCs) originating from the bone marrow play a significant role in neovascularization of ischemic tissues and in re-endothelialization of injured blood vessels. Several studies have shown the therapeutic potential of EPC transplantation in rescue of tissue ischemia and in repair of blood vessels and bioengineering of prosthetic grafts. Recent small-scale trials have provided preliminary evidence of feasibility, safety, and efficacy in patients with myocardial and critical limb ischemia. However, several studies have shown that age and cardiovascular disease risk factors reduce the availability of circulating EPCs (CEPCs) and impair their function to varying degrees. In addition, the relative scarcity of CEPCs limits the ability to expand these cells in sufficient numbers for some therapeutic applications. Priority must be given to the development of strategies to enhance the number and improve the function of CEPCs. Furthermore, alternative sources of EPC such as chord blood need to be explored. Strategies for improvement of cell adhesion, survival, and prevention of cell senescence are also essential to ensure therapeutic viability. Genetic engineering of EPCs may be a useful approach to developing these cells into efficient therapeutic tools. In the clinical arena there is pressing need to standardize the protocols for isolation, culture, and therapeutic application of EPC. Large-scale multi-center randomized trials are required to evaluate the long-term safety and efficacy of EPC therapy. Despite these hurdles, the outlook for EPC-based therapy for cardiovascular disease is promising. (Hypertension. 2005;46:7-18.)

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“…Granulocyte-colony stimulating factor (G-CSF) is well known for its mobilization of hematopoietic stem cells and more recently other cytokines such as stroma cell-derived factor 1 alpha (SDF-1a) and vascular endothelial growth factor (VEGF) also have been implicated in this trafficking process. 10,[23][24][25][26] Recently we reported that VDA treatment induced a rapid increase in circulating EPC levels, host derived VEGF, SDF-1a and G-CSF in wild-type mice, but not in G-CSF-R -/-mice. 27 Further, our unpublished data show that chemotherapy induced a rapid increase in circulating EPC levels in wild type mice and once again not in G-CSF -/-mice (Shaked Y, unpublished data).…”

Section: Resultsmentioning

confidence: 99%

Liver surgery induces an immediate mobilization of progenitor cells in liver cancer patients: A potential role for G-CSF

Langenberg¹,

Nijkamp²,

Roodhart³

et al. 2010

Cancer Biology & Therapy

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Utilizing Granulocyte Colony—stimulating Factor to Enhance Vascular Graft Endothelialization from Circulating Blood Cells

Cited by 61 publications

References 30 publications

Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing

Pivotal role of the CCL5/CCR5 interaction for recruitment of endothelial progenitor cells in mouse wound healing

Therapeutic Potential of Endothelial Progenitor Cells in Cardiovascular Diseases

Liver surgery induces an immediate mobilization of progenitor cells in liver cancer patients: A potential role for G-CSF

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