Utilizing the Knowledge of Role of Matrix Matrixmetalloproteinases Along with Tissue Inhibitors of Matrix Metalloproteinasesin Various Gynaecological Disorders with Great Emphasis on Preeclampsia, PCOs Along with Gynaecological Malignancies-A Systematic Review

Abstract

Our insight has escalated over the past decade regarding the understanding of Molecular mechanisms underlying the generation of preeclampsia, with us reviewing the role of epigenetics in the development of preeclampsia along with intra uterine growth restriction (IUGR) generation. Matrix Metalloproteinases (MM’s) MMP’s represent calcium-based zinc-endopeptidases that belong to the metzincin superfamily possessing a lot of functions like a physiological part in tissue morphogenesis, cell migration along with angiogenesis as well as in pregnancy in invasion along with migration of trophoblast besides spiral artery remodeling. Matrix Metalloproteinases (MMP), cytokines, growth factors have a role in physiological events like embryo implantation, trophoblast invasion as well as migration along with decidualization with studies documented that blastocysts are direct generators of MMP2. Thus here we decided to conduct a systematic review on the role of Matrix Metalloproteinases (MMP’s) along with their inhibitors,namely the, Tissue inhibitors of Matrix Metalloproteinases (TIMPs) in gynaecological disorders specifically in generation of preeclampsia along with IUGR; in women with Polycystic Ovarian Syndrome(PCOS); besides in spontaneous abortion along with generation of various cancers of the whole body but main emphasis on gynaecological cancers .Hence utilizing the search engine Thus we utilized Pubmed, MEDLINE, Google Scholar, Scopus, Embase, Web of Sciences, Cochrane library search engines where we utilized the MeSH terms like MMP’s in pregnancy physiological roles; pathological in preeclampsia, IUGR; miRs in these disorders; spontaneous abortion; gynaecological disorders like PCOS; gynaecological cancer along with association of certain MIR’s abnormal in IUGR that were linked to certain gliomas along with MMP’S and IUGR and further utilization of MMP inhibitors clinically, besides that since no efficacious therapy available other therapies like role of extracellular vesicles (ECV’s) that target combined miR’S that are altered and associated with MMP’s in various pathologies and effectively we can treat those disorders from 1970 till January 2021 till date. We found a total of 500 articles out of which we selected 145 articles for this review following evaluation of cross references. No meta-analysis was done. Here we provide an insight on how this knowledge on molecular mechanisms interactions of MMP’s, TIMP’s micro RNA’S might get utilized in generating therapies to prevent or treat preeclampsia, IUGR, various gynaecological malignancies developing extracellular vesicles carrying miR;s targeting specific MMP’s in particular disease or malignancy.