UV Spectrophotometric Method for Estimation of Ofloxacin in Tablet Dosage Form and Comparative Study of its Two Brands

Naveed, Safila; Alam, Tanweer

doi:10.4172/jbb.1000281

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…The in vitro drug dissolution from solid dosage form is necessary for drug bioavailability, particularly for poorly soluble drugs like Atorvastatin. 20 For this reason, after oral administration, disintegration studies can give an idea of the amount of drug available for absorption. The drugs which are poorly soluble in water have poor dissolution profile (rate determining step), they will not be sufficiently available in the body system to produce the desired therapeutic response.…”

Section: Resultsmentioning

confidence: 99%

Comparative assessment of different marketed brands of atorvastatin tablets in Asir region, Saudi Arabia

Rahamathulla

2018

MOJDDT

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IntroductionAtorvastatin (AVS) is lipid-lowering agent, which is selective, competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme. A reductase which catalyzes the conversion of HMG-CoA to mevalonate, which is a rate limiting step in cholesterol biosynthesis. AVS decreases the levels of low-density lipoprotein (bad cholesterol) and triglycerides in the blood, while enhancing the levels of highdensity lipoprotein (good cholesterol). 1-2 The empirical formula of AVS calcium is (C33H34FN2O5)2Ca2+·3H 2 O with a molecular weight of 1209.42, as shown in Figure 1. AVS is widely used to treat high cholesterol, to lower the risk of heart attack, myocardial infarction, angina, stroke, and other heart complications in people with type II diabetes and coronary heart disease. The dosage range of AVS is 10-80mg once a daily as a single dose with or without food at any time of the day. [3][4] The starting recommended dose of AVS is 10-20mg once daily, rapidly absorbed after oral administration. The half-life is approximately 12h, extensively metabolized to ortho-and para-hydroxylated derivatives and various beta-oxidation products (cytochrome P450 3A4) in the liver (hepatic metabolism) and a small amount of the drug metabolates from urine, elimination is mainly through bile. 5-7 Oral dosage forms are safest and commonest route of drug administration. The efficacy of the dosage systems can be assured when its quality is reliable. 8 The efficacy of pharmaceutical dosage systems usually depends on their formulation and manufacturing techniques, therefore the quality of dosage system may vary. [9][10][11] In this research to assess the quality/bioequivalence study of four different AVS marketed tablets (10mg) currently available in Asir region, kingdom of Saudi Arabia. They were chosen for the study to survey AVS tablets in terms of product quality and price difference in the various brands. This research was carried out for general organoleptic test, structural defects, and comparative evaluation of official and non-official quality control test such as thickness, diameter, friability, hardness, drug content uniformity, weight variation, in vitro dissolution studies, kinetic release of drug, and statistical analysis of AVS marketed/commercially available tablets, which is very useful for pharmacists and health care professionals in order to determine the interchangeability. Materials and methods MaterialsFour different marketed brands/samples of Atorvastatin calcium tablets (10mg) were purchased from community pharmacy (drug store) in Abha city, Asir region. The samples were properly checked for their drug dose, manufacturing license number, batch numbers, manufacturing and expiry dates. They were coded as A-D the details of all samples were shown in Table 1. The other solvents and chemical used in the study was analytical grade. MethodsThese are the following official and non-official quality control tests 12 are carried out during the study of different marketed brands of AVS. Uniformity of weightAccording to USP, Twenty (...

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Section: Resultsmentioning

confidence: 99%

Comparative assessment of different marketed brands of atorvastatin tablets in Asir region, Saudi Arabia

Rahamathulla

2018

MOJDDT

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“…The resulting MIL-100(Fe) effectively served as an adsorbent for the extraction of the antibiotic levofloxacin from the aqueous phase [20]. More research technique were reviewed [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37].…”

Section: Quinolones and Fluoroquinolonesmentioning

confidence: 99%

Determination of levofloxacin, norfloxacin, and moxifloxacin in pharmaceutical dosage form or individually using derivative UV spectrophotometry

Elgendy,

Zaky,

altorky

et al. 2024

BMC Chemistry

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Purpose In this study, first, second, third, and fourth-order derivative spectrophotometric methods utilizing the peak—zero (P—O) and peak-peak (P—P) techniques of measurement were developed for the determination of levofloxacin, norfloxacin, and moxifloxacin. These methods were applied to their combined pharmaceutical dosage form or individually for levofloxacin, norfloxacin, and moxifloxacin. Methods Linearity was established in the concentration range of 2–20 µg/mL. The procedures are simple, quick, and precise. The developed methods are sensitive, accurate, and cost-effective, demonstrating excellent correlation coefficients (R2 = 0.9998) and mean recovery values ranging from 99.20% to 100.08%, indicating a high level of precision. Results The developed approach was effectively employed to determine the levofloxacin, norfloxacin, and moxifloxacin content in commercially available pharmaceutical dosages. Conclusions Statistical analysis and recovery tests confirmed the method's linearity and accuracy. The results suggest that this method can be utilized for routine analysis in both bulk and commercial formulations. The simplicity, accuracy, and cost-effectiveness of the developed methods make them valuable for pharmaceutical analysis.

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UV Spectrophotometric Method for Estimation of Ofloxacin in Tablet Dosage Form and Comparative Study of its Two Brands

Cited by 2 publications

References 11 publications

Comparative assessment of different marketed brands of atorvastatin tablets in Asir region, Saudi Arabia

Comparative assessment of different marketed brands of atorvastatin tablets in Asir region, Saudi Arabia

Determination of levofloxacin, norfloxacin, and moxifloxacin in pharmaceutical dosage form or individually using derivative UV spectrophotometry

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