UV Spectrophotometric Method for theEstimation of Itopride Hydrochloride in Pharmaceutical Formulation

Abstract

Three simple, precise and economical UV methods have been developed for the estimation of itopride hydrochloride in pharmaceutical formulations. Itopride hydrochloride in distilled water shows the maximum absorbance at 258.0 nm (Method A) and in first order derivative spectra of the same shows sharp peak at 247.0 nm, when n = 1 (Method B). Method C utilises area under curve (AUC) in the wavelength range from 262.0-254.0 nm for analysis of itopride hydrochloride. The drug was found to obey Beer-Lambert’s law in the concentration range of 5-50 μg/mL for all three proposed methods. Results of the analysis were validated statistically and recovery studies were found to be satisfactory.

Simultaneous determination of a binary mixture of pantoprazole sodium and itopride hydrochloride by four spectrophotometric methods

“…Their purity were checked and found to be 100.66 ± 0.626 for PAN according to the British pharmacopoeia official method [30] which is a non-aqueous potentiometric titration method. ITH purity was found to be 99.87 ± 0.852 according to the reported method [16] which is a direct zero order spectrophotometric method.…”

“…Several analytical methods have been developed for the determination of PAN in pharmaceutical preparations such as spectrophotometric methods [3][4][5][6], HPLC methods [7][8][9][10], HPTLC-densitometric methods [11,12] and liquid chromatographic-tandem mass methods (LC-MS/MS) [13,14]. Also several methods have been reported for the determination of ITH in pharmaceutical preparations such as spectrophotometric methods [15][16][17], HPLC methods [18][19][20], HPTLC-densitometric methods [21,22] and spectroflourimetric methods [23]. Simultaneous determination of PAN and ITH has been achieved by different spectrophotometric methods [24][25][26], HPLC methods [27,28], HPTLCdensitometric methods [29], spectroflourimetric methods [23].…”

Development and Validation of a Stability Indicating HPLC Method for the Simultaneous Analysis of Esomeprazole and Itopride in Bulk and In Capsules

“…They include visible spectrophotometry (Hussainy et al, 2006;Felice and Saradhi, 2008;Choudhary et al, 2009a;Choudhary et al, 2009b;Sneha et al, 2015), ultraviolet spectrophotometry (Santosh et al, 2010;Gupta et al, 2010), spectrofluorimetry (Mohamed et al, 2013), atomic emission spectrometry (Khalil, 2013), HPLC (Kaul et al, 2005;Neeraj et al, 2005;Singh et al, 2005;Zhao, 2000;Thiruvengada et al, 2010;Payal et al, 2011), liquid chromatography with flourometric detection (Singh et al, 2005;Pavel et al, 2009;Ma et al, 2009), HPTLC (Suganthi et al, 2006Vidya et al, 2006;Dighe, 2007) and liquid chromatography with tandem mass spectrometry (Heon et al, 2007;Payal et al, 2011). Combination of esomeprazole and itopride is used for the treatment of gastric esophagus reflux disease (Peng and Li, 2009;Wang and Chen, 2012).…”

Comparison Between Lc/Uv and Gc/Fid Techniques in Determining N,NDimethylacetamide(Dma) in Diacerein

“…Diacerein, a drug with interleukin-1β inhibitory activity belonging to the class of DMARDs (Disease-Modifying Antirheumatic Drugs), is used to treat osteoarthritis and rheumatoid arthritis [3][4][5][6][7][8][9][10][11][12][13][14].…”