Uveal Melanoma: Epidemiologic Aspects

Singh, Arun D.; Bergman, Louise; Seregard, Stefan

doi:10.1016/j.ohc.2004.07.002

Cited by 268 publications

(196 citation statements)

References 128 publications

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“…In addition, up to 40% of patients die within 5 years, usually due to hepatic micrometastases 1 2. The most common sites of metastases are the liver (93%), lung (24%) and bone (16%), with 87% of patients with metastasis having multiple sites involved 3.…”

Section: Introductionmentioning

confidence: 99%

Serum vascular endothelial growth factor (VEGF) levels correlate with number and location of micrometastases in a murine model of uveal melanoma

Crosby

Yang

Gao

et al. 2010

British Journal of Ophthalmology

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BackgroundA preliminary animal study was performed to determine if hepatic micrometastases from uveal melanoma secrete vascular endothelial growth factor (VEGF) that is measurable in serum.MethodsWe analysed the serum of a C57Bl/6 mouse model of uveal melanoma (n=10) at days 4, 7, 14 and 21 post-inoculation for VEGF levels. We compared the serum VEGF levels with the number and location of hepatic micrometastases and their respective expression of VEGF mRNA.ResultsSerum VEGF levels rose after inoculation of C57Bl/6 mice eyes with B16LS9 cutaneous melanoma cells. Beginning on day 14 there was a statistically significant (p<0.05) increase in VEGF levels, rising to an average peak level of 37.985 pg/ml at day 21. Peak serum VEGF levels correlated with the total number of hepatic micrometastases (R=0.444) and there was moderate correlation of peak VEGF serum levels with micrometastases in more hypoxic locations (R=0.572). VEGF mRNA expression by micrometastases was highest in the most hypoxic regions of the hepatic lobule.ConclusionsHepatic micrometastastic melanoma arising in a mouse model of ocular melanoma secretes VEGF. The number and location of the micrometastases correlate with serum VEGF levels.

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Section: Introductionmentioning

confidence: 99%

Serum vascular endothelial growth factor (VEGF) levels correlate with number and location of micrometastases in a murine model of uveal melanoma

Crosby

Yang

Gao

et al. 2010

British Journal of Ophthalmology

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“…Although, cutaneous and uveal melanocytes share a common embryologic origin, uveal melanoma and cutaneous melanoma have many differing clinical, epidemiological and prognostic features 3 4…”

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confidence: 99%

Reduced expression of autotaxin predicts survival in uveal melanoma

Singh

Sisley

et al. 2007

British Journal of Ophthalmology

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Aim: In an effort to identify patients with uveal melanoma at high risk of metastasis, the authors undertook correlation of gene expression profiles with histopathology data and tumour-related mortality. Methods: The RNA was isolated from 27 samples of uveal melanoma from patients who had consented to undergo enucleation, and transcripts profiled using a cDNA array comprised of sequence-verified cDNA clones representing approximately 4000 genes implicated in cancer development. Two multivariate data mining techniques-hierarchical cluster analysis and multidimensional scaling-were used to investigate the grouping structure in the gene expression data. Cluster analysis was performed with a subset of 10 000 randomly selected genes and the cumulative contribution of all the genes in making the correct grouping was recorded. Results: Hierarchical cluster analysis and multidimensional scaling revealed two distinct classes. When correlated with the data on metastasis, the two molecular classes corresponded very well to the survival data for the 27 patients. Thirty two discrete genes (corresponding to 44 probe sets) that correctly defined the molecular classes were selected. A single gene (ectonucleotide pyrophosphatase/phosphodiesterase 2; autotaxin) could classify the molecular types. The expression pattern was confirmed using real-time quantitative PCR. Conclusions: Gene expression profiling identifies two distinct prognostic classes of uveal melanoma. Underexpression of autotaxin in class 2 uveal melanoma with a poor prognosis needs to be explored further.

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“…It has been suggested that it is caused by toxins diffusing into the vitreous from degenerating retina [5,6]. It is well demonstrated that the prevalence of both AH and UM increases with age [2,7,8]. While the prevalence of AH in our control group was comparable to previously reported rates, including the largest study from Bergren et al [9], it was less than the rates found in the Beaver Dam Eye Study and a study performed at the University of California at Los Angeles (UCLA) [2,3].…”

Section: Discussionmentioning

confidence: 99%

Is There an Increased Prevalence of Asteroid Hyalosis in Eyes with Uveal Melanoma A Histopathologic Study

et al. 2017

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During the planning meeting for the Collaborative Ocular Melanoma Study (COMS) prior to the start of patient recruitment in 1986, there was an interest expressed in determining whether a relationship existed between the presence of uveal melanoma (UM) and asteroid hyalosis (AH). To answer this question, the ophthalmic examination form (unlike the pathology form for enucleated eyes) for each COMS patient asked whether AH was present or not. Though an increased prevalence was not found, this result was never published. A recent unpublished study at the University of Wisconsin School of Veterinary Medicine indicated a higher prevalence of AH in canine eyes with UM when compared to control eyes (without tumor) enucleated for goniodysgenesis. This further increased our interest in revisiting the published literature, clinical records, and histopathology slides of the enucleated eyes from the COMS study, as well as the histopathology slides on file in the University of Wisconsin Eye Pathology Laboratory. While cases with both AH and UM were occasionally encountered in the literature, clinically, we could not find a previous study focusing on these two processes. This study was conducted to explore whether such an association exists.

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Uveal Melanoma: Epidemiologic Aspects

Cited by 268 publications

References 128 publications

Serum vascular endothelial growth factor (VEGF) levels correlate with number and location of micrometastases in a murine model of uveal melanoma

Serum vascular endothelial growth factor (VEGF) levels correlate with number and location of micrometastases in a murine model of uveal melanoma

Reduced expression of autotaxin predicts survival in uveal melanoma

Is There an Increased Prevalence of Asteroid Hyalosis in Eyes with Uveal Melanoma A Histopathologic Study

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