Uveitis as a potential predictor of acute myocardial infarction in patients with Behcet’s disease: a population-based cohort study

Chen, Yu‐Yen; Lai, Yun‐Ju; Yen, Yung‐Feng; Chen, Hsin‐Hua; Chou, Pesus

doi:10.1136/bmjopen-2020-042201

Cited by 3 publications

(2 citation statements)

References 49 publications

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“…Since hypertension, diabetes, hyperlipidaemia and obesity are also risk factors for cardiovascular diseases, uveitis patients may have a higher possibility for developing cardiovascular diseases. This hypothesis has been verified in our previous study using the Taiwan NHIRD [28].…”

Section: Plos Onesupporting

confidence: 76%

The risk of psoriasis in patients with uveitis: A nationwide population-based cohort study

Chen

et al. 2021

PLoS ONE

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Objective To evaluate whether the risk of subsequent psoriasis and psoriatic arthritis development is increased in patients with uveitis. Methods In Taiwan’s national health insurance research database, we identified 195,125 patients with new-onset uveitis between 2001 and 2013. We randomly selected 390,250 individuals without uveitis who were matched 2:1 to uveitis cases based on age, sex and year of enrolment. The characteristics of the two groups were compared. Using multivariate Cox regression, hazard ratios (HRs) for psoriasis or psoriatic arthritis corresponding to uveitis were computed after adjustment for age, sex, insurance cost and comorbidities. In subgroup analyses, separate HRs for mild psoriasis, severe psoriasis and psoriatic arthritis were calculated. Results The mean age of the study cohort was 50.2 ± 17.2 years. Hypertension, diabetes, hyperlipidaemia and obesity were more prevalent in the uveitis group (all p < 0.0001). The hazard of psoriasis or psoriatic arthritis development was significantly greater in the uveitis group than in the non-uveitis group (p < 0.0001); this increased risk persisted after adjustment for confounders [adjusted HR = 1.41; 95% confidence interval (CI), 1.33–1.48]. Adjusted HRs showed an increasing trend from mild psoriasis (1.35; 95% CI, 1.28–1.44) to severe psoriasis (1.59; 95% CI, 1.30–1.94) and psoriatic arthritis (1.97; 95% CI, 1.60–2.42). Conclusions This nationwide population-based cohort study revealed that patients with uveitis have an increased risk of subsequent psoriasis or psoriatic arthritis development.

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Section: Plos Onesupporting

confidence: 76%

The risk of psoriasis in patients with uveitis: A nationwide population-based cohort study

Chen

et al. 2021

PLoS ONE

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“…Predominant age of occurrence is between 3rd and 4th decades. Disease is more predominant in males with more severe disease manifestations in some Mediterranean areas [4][5][6][7][8][9].…”

Section: Epidemiologymentioning

confidence: 99%

A Short Overview of Behcet’s Disease

Shunmugavelu¹,

Dhinakaran²

2023

Rare Diseases - Recent Advances

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Behçet’s disease is a chronic, relapsing-remitting, occlusive vasculitis affecting multiple organ system. Greek physician Adamantiades had reported the disease as a classic trisymptom complex of hypopyon, iritis, and orogenital aphthosis. Behçet’s disease has an undulating course of exacerbations and remissions, and appears to be more severe in young, male, and Middle Eastern or Far Eastern patients. This article describes in brief Behçet’s disease in a new perspective.

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Association of Behçet’s disease with the risk of metabolic syndrome and its components: a systematic review and meta-analysis

Chen

Shao

et al. 2023

Clin Exp Med

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The present meta-analysis aimed to elucidate the association of Behçet’s disease (BD) with the risk of metabolic syndrome (MetS) and its components. Observational cohort studies were searched from the Embase, Web of Science, Medline, and Cochrane Library databases. The primary outcome was the association of BD with the risk of MetS and its relevant components. Effect estimates with odds ratios (ORs) were pooled using either the random-effects or fixed-effects models, according to heterogeneity. Leave-one-out sensitivity analyses were used to determine the stability of the results. Twenty-three studies, comprising 42,834 patients with BD, were included. Overall, a significant association between BD and the risk of MetS was found (pooled OR 2.26; 95% confidence interval [CI] 1.61–3.17; P < 0.0001). Among the components of MetS, significant associations were found between BD and diabetes mellitus (OR 1.21; 95% CI 1.10–1.33; P < 0.0001), BD and hypertension (OR 1.39; 95% CI 1.13–1.70; P = 0.002), and BD and dyslipidemia (OR 1.21; 95% CI 1.01–1.45; P = 0.04). Our study indicated an association between BD and the risk of MetS and some of its components (diabetes mellitus, hypertension, and dyslipidemia). Physician should consider these associations so that specific treatments are available for patients with comorbidities. Moreover, patients with BD should regularly monitor their blood pressure, fasting plasma glucose, and blood lipid levels.

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Uveitis as a potential predictor of acute myocardial infarction in patients with Behcet’s disease: a population-based cohort study

Cited by 3 publications

References 49 publications

The risk of psoriasis in patients with uveitis: A nationwide population-based cohort study

The risk of psoriasis in patients with uveitis: A nationwide population-based cohort study

A Short Overview of Behcet’s Disease

Association of Behçet’s disease with the risk of metabolic syndrome and its components: a systematic review and meta-analysis

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