V. Negundo, L. Camara and B. Variegata Plants Leaf Extract Exhibit Considerable in Vitro Antioxidant and Anticancer Activities

Badgujar, Nutan V.; Mistry, Kinnari N.; Patel, Jagdish Suresh

doi:10.22159/ijpps.2017v9i5.17721

Cited by 7 publications

(6 citation statements)

References 30 publications

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“…In a recent study, they have also got the similar results [36]. In a similar study, methanolic extract of Lantana camara showed minimum IC 50 value for DPPH assay (48.75±2.34 µg/ml) [37].…”

Section: Discussionmentioning

confidence: 55%

Green Synthesis and Characterization of Marine Yeast-Mediated Silver and Zinc Oxide Nanoparticles and Assessment of Their Antioxidant Activity

Aswathy

Gabylis

et al. 2017

Asian J Pharm Clin Res

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Objective: The present study focuses on the synthesis of silver and zinc oxide (ZnO) nanoparticles from marine yeasts, isolated from the sediments of the Bay of Bengal, Bakkhali coast, West Bengal, and India. Methods:The marine sediment samples were diluted through serial diution and cultured onto yeast malt agar medium by the spread plate method. The selected yeast isolates were screened for the biosynthesis of silver and ZnO nanoparticles. Characterization of both the nanoparticles was done by applying ultraviolet (UV)-visible spectroscopy, atomic force microscopy, scanning electron microscopy, and Fourier transform infrared spectroscopy.Results: A total of five marine yeasts isolates were able to synthesize silver and ZnO nanoparticles as evidence of the color change. Optical density was measured in UV-spectrometer at different time interval for the conformation of production of nanoparticles. The size of silver nanoparticle was 31.78 nm and ZnO nanoparticle was 86.27 nm. The synthesized nanoparticles are then used for antioxidant assays. Conclusions:We are concluding that marine yeast isolates SAG1 and SAG2 both are potential marine yeast isolates which can synthesize both the silver and ZnO nanoparticles. They also showed good antioxidant activity.

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Section: Discussionmentioning

confidence: 55%

Green Synthesis and Characterization of Marine Yeast-Mediated Silver and Zinc Oxide Nanoparticles and Assessment of Their Antioxidant Activity

Aswathy

Gabylis

et al. 2017

Asian J Pharm Clin Res

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“…Traditional plants are an important source of a natural remedies and remain to be broadly used to treat many diseases [18]. An infusion of the leaf and juice of the fruit is diuretic, and flower is said to have stimulant properties.…”

Section: Traditional Uses Of D Repensmentioning

confidence: 99%

Duranta Repens Linn. (Verbenaceae): A Comprehensive Review of Pharmacognostic, Ethnomedicinal, Pharmacological, and Phytochemical Aspects

Puri¹

2018

Asian J Pharm Clin Res

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Objective: This review is intended to investigate the published report regarding phytochemical, ethnomedicinal, and pharmacological activities and put forth the therapeutic potential of Duranta repens Linn. (D. repens). It belongs to the family Verbenaceae, one of the therapeutically important plants, broadly distributed all throughout the world. It is commonly referred as golden dewdrop, angel whisper, pigeon berry, or skyflower.Methods: I utilized logical writing and scientific literature regarding D. repens by referring search engine such as Springerlink, ScienceDirect, SciFinder, PubMed, Scopus, Google Scholar, and BioMed Central as well as relevant books, websites, scientific publications, and dissertations as a source of information that provided an up-to-date review. My work on morphology and extraction of various phytochemicals and their evaluation has helped to provide an insightful account of D. repens.Results: Phytochemical profiling of these species revealed the presence of some imperative phytochemicals such as alkaloids, flavonoids, glycosides, phenolics, saponins, steroids, tannins and terpenoids as the basis of its valuable therapeutic properties. The other imperative phytoconstituents which contribute to the therapeutic properties are durantol, repennoside, repenins, and scutellarein. The pharmacological activities exhibited by D. repens as antimicrobial, antioxidant, and insecticide properties are attributed to the presence of valuable bioactive phytoconstituents.Conclusion: Considering these facts, I endeavored to present a comprehensive review enlightening the phytochemistry and pharmacological activities of plant D. repens. Future research can be directed to an extensive investigation about phytochemistry, clinical trials, pharmacokinetics, and acquiring safety data so as to add new dimensions to the therapeutic utilization of D. repens and other Duranta species.

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“…On hydrogenation on PtO 2 , these compounds furnished dioxolanones 477e479 whose acid hydrolysis permitted the isolation of 480e482, side chains of deoxyHT (5), homodeoxyHT (22), and nordeoxyHT (21), respectively. When 453 was alkylated with benzyl bromide, the same sequence allowed the obtention of 483, the side chain of neoHT (19).…”

Section: Tietze's Synthesis (2005)mentioning

confidence: 99%

Cephalotaxus Alkaloids

Pérard-Viret

Quteishat

Alsalim

et al. 2017

The Alkaloids: Chemistry and Biology

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Cephalotaxus alkaloids represent a family of plant secondary metabolites known for 60 years. Significant activity against leukemia in mice was demonstrated for extracts of Cephalotaxus. Cephalotaxine (CET) (1), the major alkaloid of this series was isolated from Cephalotaxus drupacea species by Paudler in 1963. The subsequent discovery of promising antitumor activity among new Cephalotaxus derivatives reported by Chinese, Japanese, and American teams triggered extensive structure elucidation and biological studies in this family. The structural feature of this cephalotaxane family relies mainly on its tetracyclic alkaloid backbone, which comprises an azaspiranic 1-azaspiro[4.4]nonane unit (rings C and D) and a benzazepine ring system (rings A and B), which is linked by its C3 alcohol function to a chiral oxygenated side chain by a carboxylic function alpha to a tetrasubstituted carbon center. The botanical distribution of these alkaloids is limited to the Cephalotaxus genus (Cephalotaxaceae). The scope of biological activities of the Cephalotaxus alkaloids is mainly centered on the antileukemic activity of homoharringtonine (HHT) (2), which in particular demonstrated marked benefits in the treatment of orphan myeloid leukemia and was approved as soon as 2009 by European Medicine Agency and by US Food and Drug Administration in 2012. Its exact mechanism of action was partly elucidated and it was early recognized that HHT (2) inhibited protein synthesis at the level of the ribosome machinery. Interestingly, after a latency period of two decades, the topic of Cephalotaxus alkaloids reemerged as a prolific source of new natural structures. To date, more than 70 compounds have been identified and characterized. Synthetic studies also regained attention during the past two decades, and numerous methodologies were developed to access the first semisynthetic HHT (2) of high purity suitable for clinical studies, and then high grade enantiomerically pure CET (1), HHT (2), and analogs.

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V. Negundo, L. Camara and B. Variegata Plants Leaf Extract Exhibit Considerable in Vitro Antioxidant and Anticancer Activities

Cited by 7 publications

References 30 publications

Green Synthesis and Characterization of Marine Yeast-Mediated Silver and Zinc Oxide Nanoparticles and Assessment of Their Antioxidant Activity

Green Synthesis and Characterization of Marine Yeast-Mediated Silver and Zinc Oxide Nanoparticles and Assessment of Their Antioxidant Activity

Duranta Repens Linn. (Verbenaceae): A Comprehensive Review of Pharmacognostic, Ethnomedicinal, Pharmacological, and Phytochemical Aspects

Cephalotaxus Alkaloids

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