Vaccination demonstration zone successfully controls rabies in Guangxi Province, China

Wei, Xian-Kai; Xiong, Yi; Li, Xiaoning; Zheng, Min; Pan, Yawen; He, Xiaoliang; Liang, Jingjing; Liu, Cheng; Zhong, Yi‐Zhi; Zou, Lianbin; Li, Zheng; Guo, Jiang; Li, Changting; ShengBin, Huang; Jiazhong, Gan; Meng, Zhenmu; Yang, Jian; Tang, Hai-Bo; Liu, Qi; Luo, Ting

doi:10.1186/s12879-018-3301-8

Cited by 8 publications

(16 citation statements)

References 22 publications

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“…Additional work is needed to ensure the thorough investigation of human animal wounds by collecting information on the health and vaccination status of the animal as well as by fully engaging the various animal health sectors for follow-up on suspect rapid and dead animals [ 2 , 11 ]. Improving diagnostic testing for rabies [ 22 ] and implementing dog vaccination campaigns [ 24 ] are also needed. Although these steps are important components of rabies elimination, this project highlights the importance of ensuring access and quality delivery of rabies PEP and RIG following possible exposures [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Assessing clinicians’ Post-Exposure Prophylaxis recommendations for rabies virus exposures in Hunan Province, China

et al. 2021

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Background Timely and appropriate administration of post-exposure prophylaxis (PEP) is an essential component of human rabies prevention programs. We evaluated patient care at rabies clinics in a high-risk county in Hunan Province, China to inform strategies needed to achieve dog-mediated human rabies elimination by 2030. Methods We collected information on PEP, staff capacity, and service availability at the 17 rabies clinics in the high-risk county during onsite visits and key staff interviews. Additionally, we conducted observational assessments at five of these clinics, identified through purposive sampling to capture real-time information on patient care during a four-week period. Wound categories assigned by trained observers were considered accurate per national guidelines for comparison purposes. We used the kappa statistic and an alpha level of 0.05 to assess agreement between observers and clinic staff. Results In 2015, the 17 clinics provided PEP to 5,261 patients. Although rabies vaccines were available at all 17 clinics, rabies immune globulin (RIG) was only available at the single urban clinic in the county. During the assessment period in 2016, 196 patients sought care for possible rabies virus exposures. According to observers, 88 (44%) patients had category III wounds, 104 (53%) had category II wounds and 4 (2%) had category I wounds. Observers and PEP clinic staff agreed on approximately half of the assigned wound categories (kappa = 0.55, p-value< 0.001). Agreement for the urban county-level CDC clinic (kappa = 0.93, p-value<0.001) was higher than that of the rural township clinics (kappa = 0.16, p-value = 0.007). Using observer assigned wound categories, 142 (73%) patients received rabies vaccinations and RIG as outlined in the national guidelines. Conclusion Rabies PEP services were available at each town of the project county; however, gaps between clinical practice of PEP and recommendations of national rabies guidelines were identified. We used these findings to develop and implement a training to rabies clinic staff on wound categorization, wound care, and appropriate use of PEP. Additional risk-based approaches for evaluating human rabies virus exposures may be needed as China progresses towards elimination.

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Section: Discussionmentioning

confidence: 99%

Assessing clinicians’ Post-Exposure Prophylaxis recommendations for rabies virus exposures in Hunan Province, China

et al. 2021

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“…Around 47% of the studies (Borse et al, 2018;Hudson et al, 2019;Jeon et al, 2019;Laager et al, 2018;S. Musaili & Chepkwony, 2020;Taib et al, 2019;Wei et al, 2018;Yoder et al, 2019) included in our review were publications from the past three years while the remaining percentage (Bilinski et al, 2016;Dumas et al, 2015;Ferguson et al, 2015;Fitzpatrick et al, 2016;Mindekem et al, 2017;Muthiani et al, 2015;Velasco-Villa et al, 2017;E Wera et al, 2017;Ewaldus Wera et al, 2017) were published from the year 2015 to year 2017. Six studies (35%) were concerned on rabies in the continent of Africa; two in Chad (Mindekem et al, 2017;Yoder et al, 2019) one in Mali (Muthiani et al, 2015), one in Kenya (S. Musaili & Chepkwony, 2020), one in Tanzania (Bilinski et al, 2016) and one study in East Africa (Borse et al, 2018).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…In one study, the focus was on rabies in the Western Hemisphere region (Velasco-Villa et al, 2017) including North America, Central and South America and the Caribbean. A single study was conducted each for rabies in Australia (Wei et al, 2018), China (Laager et al, 2018), India (Fitzpatrick et al, 2016), France (Dumas et al, 2015) and in Latin America (Jeon et al, 2019). However, one study (Hudson et al, 2019) did not specify its study country as the researchers only simulated hypothetical scenarios.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The evaluation of rabies intervention effectiveness was considered at different levels of rabiesrisk (endemic, epidemic, and rabies-free). Although the endemic setting was the focal point in most literatures, three studies (Dumas et al, 2015;Hudson et al, 2019;Wei et al, 2018) have analysed the effectiveness of rabies prevention and control strategies in a rabies-free scenario. There were 13 studies utilising mathematical models to simulate disease transmission; nine (Bilinski et al, 2016;Fitzpatrick et al, 2016;Hudson et al, 2019;Mindekem et al, 2017;S.…”

Section: Effectiveness Evaluationmentioning

confidence: 99%

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A Scoping Review of the Effectiveness of Control Interventions of Human and Canine Rabies in an Effort to Rationalise the One Health Approach

Taib¹,

Safii²

2020

Borneo Epid J

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According to the World Health Organization (WHO), rabies is one of the 18 neglected tropical diseases, together with dengue, leprosy, and trachoma, among others. Despite being a vaccine-preventable disease, the latest estimate of annual human rabies mortality from a 2015 study is as high as 59,000 throughout 150 countries. In human rabies, more than 95% of the cases are due to dog bites, making the elimination of canine rabies a global priority by fighting the disease at its animal source. World Health Organization (WHO), World Organization for Animal Health (OIE), Food and Agriculture Organization (FAO) of the United Nations, and the Global Alliance for Rabies Control (GARC) have warranted the One Health framework with the objective of complete eradication of dog-related human rabies by the year 2030. In an effort to rationalise the One Health approach, this scoping review found 17 studies on assessing the effectiveness of control interventions of human and canine rabies. Different strategies were implemented based on the endemicity of rabies in a particular country. Overall, the combined strategies using the One Health approach, which allows effective participation and communication between different agencies, have shown promising results in reducing rabies cases. These strategies will hopefully realise the goal in the Global Strategic Plan to achieve zero canine-mediated human rabies death by the year 2030.

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“…It is recognized that dogs are the largest population of animals that transmitted rabies to a human. Rabies disease can be prevented by dog vaccination (Wei, et al, 2018;Zhu & Guo, 2016).…”

Section: Introductionmentioning

confidence: 99%

Human behaviour in keeping dogs and its relationship to rabies

Setiawan

Probandari

Pamungkasari

et al. 2018

IRJMIS

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This study was a qualitative study that conducted in Bali, Indonesia. Bali has been an endemic of rabies since 2008. Many factors have been related to rabies. One of them is human behavior. This research was focused on human behavior in keeping dogs and its relationship to rabies. The study was conducted in 3 villages at Buleleng regency where positive rabies dogs have been found in 2017. There was a high population of dogs in the villages, and most of them lived wildly. Data were collected through document review, interview, and direct observation. After being collected, they were analyzed using content analysis. Results of this research show that most of the villagers had been aware of rabies, but has got poor knowledge about it. They did not know how to prevent it, especially on how to threat wound caused by rabies dogs' bite. Furthermore, the villagers did not give any vaccine to their dogs. They only waited for the vaccine officer from the government to come to their house. The main problems in preventing rabies, related to human behavior, based on this research are: 1) lack of village's leaders involvement, especially in controlling and administering prevention program, 2) lack of people respond in controlling dogs population and dogs mobility, 3) lack of active participation of dogs owners to vaccinate their dogs and 4) lack of people knowledge about PEP procedures.

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Vaccination demonstration zone successfully controls rabies in Guangxi Province, China

Cited by 8 publications

References 22 publications

Assessing clinicians’ Post-Exposure Prophylaxis recommendations for rabies virus exposures in Hunan Province, China

Assessing clinicians’ Post-Exposure Prophylaxis recommendations for rabies virus exposures in Hunan Province, China

A Scoping Review of the Effectiveness of Control Interventions of Human and Canine Rabies in an Effort to Rationalise the One Health Approach

Human behaviour in keeping dogs and its relationship to rabies

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