Vaccination with a cocktail vaccine elicits significant protection against Sarcoptes scabiei in rabbits, whereas the multi-epitope vaccine offers limited protection

Shen, Nengxing; Wei, Wenrui; Chen, Yuhang; Liu, Song; Xiong, Lang; Xiao, Jie; Gu, Xiaobin; Xie, Yue; Xu, Jing; Jing, Bo; Peng, Xuerong; Yang, Guangyou

doi:10.1016/j.exppara.2022.108442

Experimental Parasitology

2023

DOI: 10.1016/j.exppara.2022.108442

|View full text |Cite

Vaccination with a cocktail vaccine elicits significant protection against Sarcoptes scabiei in rabbits, whereas the multi-epitope vaccine offers limited protection

Nengxing Shen

Wenrui Wei

Yuhang Chen

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Scabies vaccines: where we stand and challenges ahead

Sharaf

2024

Parasitol Res

View full text Add to dashboard Cite

Scabies is an itchy skin disease caused by the burrowing mite, Sarcoptes scabiei. During their lifespan, female mites invade the stratum corneum and create tunnels in which they reside, move, feed, deposit fecal pellets, and lay eggs. Globally, more than 200 million people are estimated to be affected by scabies annually. Currently, using scabicidal agents is the only approved method for treating scabies. However, resistance to commonly used agents such as permethrin and ivermectin has been observed in scabies mites. Therefore, the development of vaccines for scabies, either as a preventative measure or for treatment, is crucial to control such neglected diseases. Since the host could evolve a protective immune response that could prevent re-infestation by scabies mites, vaccine development is theoretically possible. This review aims to provide a comprehensive overview of the ongoing challenges regarding the currently available control measures for scabies. It also explores the promising path of scabies vaccine development, highlighting the current state of research and challenges that need to be addressed to develop new and innovative measures for both treating and preventing scabies infections.

show abstract

Scabies vaccines: where we stand and challenges ahead

Sharaf

2024

Parasitol Res

View full text Add to dashboard Cite

show abstract

Sarcoptic mange in domestic rabbits: Pathogenesis, impact, and control strategies

Singh,

Srivastava,

Yadav

et al. 2025

Veterinary Parasitology

View full text Add to dashboard Cite

Mange in farmed rabbits

Rosell,

De la Fuente,

Casais

2024

World Rabbit Sci.

View full text Add to dashboard Cite

In this study we determined occurrence of mange in breeding rabbits on 1368 commercial farms in Portugal and Spain during 1996-2022. We obtained our information by carrying out 11 737 visits to 1334 doe farms, 11 farms only with growers, and 23 artificial insemination (AI) centres. The median size of the visited doe farms was 450 does (minimum to maximum: 100–2500 does) and 1175 does (ranging from100 to 6000 does) in 1996 and 2022, respectively. AI was used on 9% of the farms visited in 1996 and 95% in 2022. For our diagnoses we used (1) clinical observations on all visited farms to detect sarcoptic mange; (2) examination of the outer ear of breeding rabbits on a subset of farms to assess the prevalence of otodectic clinical mange (OCM); and (3) the examination of breeding rabbits and youngstock does (2.5 to 5.5 mo old) on a subset of 72 farms during 2018 to estimate prevalence of body mange compatible with cheyletiellosis. They were mainly clinical diagnoses, supported sometimes by a laboratorial confirmation. Over the course of the 27-yr clinical study, the cumulative incidence of sarcoptic mange was low; we recorded a total of 13 affected doe farms. The percentage of farms affected by OCM dropped from 55% in 1996 to 28% in 2022. OCM mean prevalence for the period 1996-2022 and 95% binomial confidence interval (CI) were 3.2% (95% CI [3.1-3.3%]), and 3.9% (95% CI [3.7-4.1%]) in does and bucks, respectively. We observed an improvement over time; the OCM yearly mean prevalence decreased from 7% in 1996 to 2.3% in 2022 in females and from 7.2% to 2.2% in males, respectively. This progress was compatible with the use of semen coming from AI centres; biosecurity measures and medical management also contributed. Genetic type was predisposing risk factor for OCM. Enabling risk factors were year and season (more affected in summer). Hair and skin disorders along the back, compatible with cheyletiellosis, were also assessed during 2018; we detected 50% of positive farms with various prevalence results in females, males or young does. In this study, we describe protocols observed in the control of benign and severe cases of mange in rabbitries, which included the use of ivermectin and synthetic acaricides. Ivermectin was used on 36% of doe farms visited during 2018-2022; we suggest that it should be used less often to lower its negative impact on the environment.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Vaccination with a cocktail vaccine elicits significant protection against Sarcoptes scabiei in rabbits, whereas the multi-epitope vaccine offers limited protection

Cited by 3 publications

References 47 publications

Scabies vaccines: where we stand and challenges ahead

Scabies vaccines: where we stand and challenges ahead

Sarcoptic mange in domestic rabbits: Pathogenesis, impact, and control strategies

Mange in farmed rabbits

Contact Info

Product

Resources

About