Vaccinations and Type 1 Diabetes

Antonelli, Alessandro; Ferrari, Silvia; Domenicantonio, Andrea Di; Ferrannini, Ele; Fallahi, Poupak

doi:10.1002/9781118663721.ch29

Cited by 1 publication

(2 citation statements)

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“…Type 1 diabetes (T1D) is a chronic disease which results from the impaired metabolism of glucose, leading to a high concentration of glucose in the circulation (Antonelli, Ferrari, Di Domenicantonio, Ferrannini, & Fallahi, 2015). It is characterized by the progressive and selective destruction of pancreatic beta cells in genetically predisposed individuals during childhood and adolescence (Richardson, Willcox, Bone, Morgan, & Foulis, 2011), although some epidemiological studies have indicated that its incidence may be comparable to adults in some countries (Molbak, Christau, Marner, Borch-Johnsen, & Nerup, 1994).…”

Section: Introductionmentioning

confidence: 99%

“…Enteroviruses are transmitted via the fecal-oral route and replicate primarily in the gut. The systemic infection may lead to the dissemination to other target organs (Antonelli et al, 2015;Hankaniemi et al, 2017). The viruses from the Enterovirus genus do not have a lipid envelope and their genome is encoded as single-stranded RNA, which is protected by an icosahedral capsid (Nasri et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Effects of bovine enterovirus and type 1 diabetes on liver and kidney pyruvate kinase activity in an animal model

Dalzochio

Nienov

Wannmacher

et al. 2019

Acta Sci. Biol. Sci.

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Type 1 diabetes (T1D) is an autoimmune disease characterized by the selective destruction of pancreatic beta cells. In addition to genetic factors, enteroviruses have been considered the main environmental factor involved in this pathology. Therefore, the objective of this study was to evaluate the effects of streptozotocin-induced diabetes and bovine enterovirus (BEV) on liver and kidney pyruvate kinase activity in rats. Fourteen male Wistar rats were divided in three groups: control, diabetes and a third group, which was fed with water experimentally contaminated by BEV. Increased blood glucose levels were found in both diabetes and enterovirus groups, whereas there were no alterations in the lipid profile. A reduced pyruvate kinase activity was observed in the liver and kidney of animals from diabetes and enterovirus groups. Under our experimental conditions, the ingestion of water experimentally contaminated by BEV induced alterations in glycaemia, and also interfered in the pyruvate kinase activity in liver and kidney of the rats, which might be one of the possible mechanisms involved in the T1D development.

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Section: Introductionmentioning

confidence: 99%