Vaccines for preventing hepatitis B in health-care workers

Antibody to Hepatitis B Surface Antigen in Vaccinated Health Care Workers

“…The standard HBV vaccine schedule of 0,1,6 month with 20 mcg HBsAg/dose as deep deltoid, intramuscular injection in HCW was found to be immunogenic as recommended by other workers [6,16]. Various studies experimenting with low dose intra-dermal route have reported decreased immunogenic response [17].…”

Evidence-based clinical guidelines for immigrants and refugees

“…A recent meta-analysis of the effectiveness of hepatitis B vaccination among health care workers (in countries where the incidence of hepatitis B virus infection is low) showed that vaccination decreased the acquisition of acute infection by 68% (95% CI 35%-84%) relative to those who were unvaccinated. 185 Because in adults it is uncommon for chronic infection with hepatitis B virus to develop following acute infection (< 5%), we were unable to identify any studies that measured the effectiveness of vaccine to decrease morbidity or mortality associated with chronic infection with hepatitis B virus in adults.…”

Background paper to the revised recommendation for hepatitis B vaccination of persons at particular risk and for hepatitis B postexposure prophylaxis in Germany

“…Only 39% of these sought medical care Personnel in facilities where an increased prevalence of HBVinfected persons is likely to be present Breuer et al [28] Cohort study, US Teachers and school children are at increased risk of hepatitis B infection if they come in contact with an HBsAg carrier in the classroom Remis et al [29] Cohort study, Canada Teachers at schools for the mentally handicapped can be at increased risk of hepatitis B infection "vaccin*"; "immunization"; "random*"; "blind*"; "placebo"; "meta-analys*"; "cohort"; "time series"; "case-control"; "ecological"; "cross-sectional"). Additionally, the results of four Cochrane Reviews [32,33,34,35] and one meta-analysis [36] relevant to the topic were considered.…”