Vaccines in the Immunocompromised Hosts

Prasad, Paratosh; Treanor, John J.

doi:10.1007/978-3-319-77674-3_18

Cited by 1 publication

(2 citation statements)

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“…Patients had mostly CD4+T cell counts >200 cell/mm 3 and were on ART. Berkowitz et al 36 analyzed different groups of patients according to different number of CD4+T cells and presence of ART. However, the study included only a few patients with very low CD4+ T cell counts, even if it has been found no impact on HIV RNA concentrations or CD4+ T cell numbers during the study.…”

Section: Discussionmentioning

confidence: 99%

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Immunogenicity and safety of live attenuated and recombinant/inactivated varicella zoster vaccines in people living with HIV: A systematic review

Carta,

Mangeri,

Tiecco

et al. 2024

Human Vaccines & Immunotherapeutics

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Few papers focus their attention on VZV vaccination effectiveness among people living with HIV (PLWH). Flanking the live attenuated vaccine (VZL) available, a newly recombinant vaccine (RZV) was recently introduced and approved for HZ prevention among adults. PLWH represents a population on which a particular attention should be applied, in order to guarantee the vaccine efficacy and safety. We performed a literature search in USNLM, PubMed, PubMed Central, PMC and Cochrane Library. From all the publications found eligible, data were extracted and processed per population, vaccine type, immunogenicity and ADRs. The review of the 13 included studies shows that both RZV and VZL are immunogenic and have an acceptable safety profile in adults and children living with HIV. However, given the lack of research available about vaccine efficacy in preventing VZV and HZ in PLWH, additional studies need to be performed, in order to achieve a full completeness of data.

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Section: Discussionmentioning

confidence: 99%

“…This therapy is often ineffective because of potential drug toxicities, prolonged treatment durations, viral resistance, and drug-drug interactions especially in such patients subjected to the use of multiple drugs. 36 …”

Section: Introductionmentioning

confidence: 99%