Vacinas Contra a Covid-19: Um Panorama dos Imunizantes Desenvolvidos no Cenário Mundial

Cruz, Cleide Mara Barbosa da; Silva, Anderson Rosa da; Rezende, Cristiane Monteiro de Farias; Santos, Mário Jorge Campos dos; Fabris, Jonas Pedro

doi:10.12819/2021.18.6.11

Cited by 1 publication

(1 citation statement)

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“…Globally, exceptional eforts have been employed to control, treat, and reduce the impact and spread of SARS-CoV-2. As of 2023 (three years after the WHO announced COVID-19 as a pandemic), there are at least 18 approved vaccines under mass immunization drive (Table 1 [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]). Furthermore, Food and Drug Administration (FDA) special program known as Coronavirus Treatment Acceleration Program (CTAP) also reports a single agent (antivirals, cell and gene therapy, immunomodulators, and neutralizing antibodies) and combination agents for COVID-19 treatment with nine authorized for emergency use [23].…”

Section: Introductionmentioning

confidence: 99%

A Brief Review on Medicinal Plants-At-Arms against COVID-19

Srivastava

Huang

et al. 2023

Interdisciplinary Perspectives on Infectious Diseases

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COVID-19 pandemic caused by the novel SARS-CoV-2 has impacted human livelihood globally. Strenuous efforts have been employed for its control and prevention; however, with recent reports on mutated strains with much higher infectivity, transmissibility, and ability to evade immunity developed from previous SARS-CoV-2 infections, prevention alternatives must be prepared beforehand in case. We have perused over 128 recent works (found on Google Scholar, PubMed, and ScienceDirect as of February 2023) on medicinal plants and their compounds for anti-SARS-CoV-2 activity and eventually reviewed 102 of them. The clinical application and the curative effect were reported high in China and in India. Accordingly, this review highlights the unprecedented opportunities offered by medicinal plants and their compounds, candidates as the therapeutic agent, against COVID-19 by acting as viral protein inhibitors and immunomodulator in (32 clinical trials and hundreds of in silico experiments) conjecture with modern science. Moreover, the associated foreseeable challenges for their viral outbreak management were discussed in comparison to synthetic drugs.

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