Vacuna conjugada contra el neumococo: ¿Es una prevención universal adecuada de la enfermedad neumocócica?

Gorrotxategi, Pedro Gorrotxategi; Mata, A. Iturrioz

doi:10.4321/s1139-76322010000400009

Cited by 1 publication

(1 citation statement)

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“…In Gipuzkoa, PCV7 was introduced in 2001 for vaccination in a private market (non-subsidized), with progressive children uptake up to 40–60% ( 11 ). In 2010, PCV7 was replaced by PCV13 which in 2016 was included in the children vaccination schedule of the public health service with coverages over 95%.…”

Section: Introductionmentioning

confidence: 99%

Impact of the progressive uptake of pneumococcal conjugate vaccines on the epidemiology and antimicrobial resistance of invasive pneumococcal disease in Gipuzkoa, northern Spain, 1998–2022

Manzanal,

Vicente,

Alonso

et al. 2023

Front. Public Health

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ObjectivesTo analyze the impact of pneumococcal conjugate vaccines (PCVs) on the incidence of invasive pneumococcal diseases (IPDs) and pneumococcal antibiotic resistance in Gipuzkoa, northern Spain for a 25 years period.MethodsAll cases of IPD confirmed by culture between 1998 and 2022 in a population of around 427,416 people were included. Pneumococci were serotyped and antimicrobial susceptibility was assessed by the EUCAST guidelines.ResultsOverall, 1,516 S. pneumoniae isolates were collected. Annual IPD incidence rates (per 100,000 people) declined from 19.9 in 1998–2001 to 11.5 in 2017–19 (42.2% reduction), especially in vaccinated children (from 46.7 to 24.9) and non-vaccinated older adult individuals (from 48.0 to 23.6). After PCV13 introduction, the decrease in the incidence of infections caused by PCV13 serotypes was balanced by the increase in the incidence of non-PCV13 serotypes. In the pandemic year of 2020, IPD incidence was the lowest: 2.81. The annual incidence rates of penicillin-resistant isolates also decreased, from 4.91 in 1998–2001 to 1.49 in 2017–19 and 0.70 in 2020. Since 2017, serotypes 14, 19A, and 11A have been the most common penicillin-resistant types. The incidence of erythromycin-resistant strains declined, from 3.65 to 1.73 and 0.70 in the same years.ConclusionPCV use was associated with declines in the incidence of IPD and the spread of non-vaccine serotypes, that balanced the beneficial effect off PCV13, some of them showing high rates of antibiotic resistance.

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Section: Introductionmentioning

confidence: 99%