Vagal afferent pathway mediates physiological action of cholecystokinin on pancreatic enzyme secretion.

Li, Ying; Owyang, Chung

doi:10.1172/jci116583

Cited by 181 publications

(156 citation statements)

References 25 publications

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“…CCK is involved in the endocrine cells in the upper small intestine, principally acting to stimulate gallbladder contractions [34] and pancreatic secretion [35] , and to delay gastric emptying after meals [26] . Evidence has shown that CCK, stimulated by nutrients, is a physiological mediator which inhibits gastric emptying and subsequently suppresses food intake [26] .…”

Section: Discussionmentioning

confidence: 99%

Levels of vasoactive intestinal peptide, cholecystokinin and calcitonin gene-related peptide in plasma and jejunum of rats following traumatic brain injury and underlying significance in gastrointestinal dysfunction

Hang¹,

Shi²,

Li³

et al. 2004

WJG

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AIM:To study the alterations of brain-gut peptides following traumatic brain injury (TBI) and to explore the underlying significance of these peptides in the complicated gastrointestinal dysfunction. METHODS:Rat models of focal traumatic brain injury were established by impact insult method, and divided into 6 groups (6 rats each group) including control group with sham operation and TBI groups at postinjury 3, 12, 24, 72 h, and d 7. Blood and proximal jejunum samples were taken at time point of each group and gross observations of gastrointestinal pathology were recorded simultaneously. The levels of vasoactive intestinal peptide (VIP) in plasma, calcitonin gene-related peptide (CGRP) and cholecystokinin (CCK) in both plasma and jejunum were measured by enzyme immunoassay (EIA). Radioimmunoassay (RIA) was used to determine the levels of VIP in jejunum. RESULTS:Gastric distension, delayed gastric emptying and intestinal dilatation with a large amount of yellowish effusion and thin edematous wall were found in TBI rats through 12 h and 72 h, which peaked at postinjury 72 h. As compared with that of control group (247.8±29.5 ng/L), plasma VIP levels were significantly decreased at postinjury 3, 12 and 24 h (106.7±34

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Section: Discussionmentioning

confidence: 99%

Levels of vasoactive intestinal peptide, cholecystokinin and calcitonin gene-related peptide in plasma and jejunum of rats following traumatic brain injury and underlying significance in gastrointestinal dysfunction

Hang¹,

Shi²,

Li³

et al. 2004

WJG

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“…The relative contribution of these mechanisms may depend on the stage of postnatal development of the duodenum and pancreas (Biernat et al 1999). Studies in anaesthetised rats with CCK peptide and CCK 1 receptor antagonists administrations showed similar results (Li & Owyang, 1993, 1994, leading to a conclusion that in physiological conditions the prandial secretory response of the exocrine pancreas is chiefly driven by a neurohormonal mechanism, and a direct interaction of CCK with CCK 1 receptor on pancreatic acini is just a pharmacological effect (Owyang, 1996).…”

Section: Global Effects Of Gastrin and Cholecystokinin In The Gutmentioning

confidence: 97%

Gastrin, cholecystokinin and gastrointestinal tract functions in mammals

et al. 2006

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The aim of the present review is to synthesise and summarise our recent knowledge on the involvement of cholecystokinin (CCK) and gastrin peptides and their receptors in the control of digestive functions and more generally their role in the field of nutrition in mammals. First, we examined the release of these peptides from the gut, focusing on their molecular forms, the factors regulating their release and the signalling pathways mediating their effects. Second, general physiological effects of CCK and gastrin peptides are described with regard to their specific receptors and the role of CCK on vagal mucosal afferent nerve activities. Local effects of CCK and gastrin in the gut are also reported, including gut development, gastrointestinal motility and control of pancreatic functions through vagal afferent pathways, including NO. Third, some examples of the intervention of the CCK and gastrin peptides are exposed in diseases, taking into account intervention of the classical receptor subtypes (CCK 1 and CCK 2 receptors) and their heterodimerisation as well as CCK-C receptor subtype. Finally, applications and future challenges are suggested in the nutritional field (performances) and in therapy with regards to the molecular forms or in relation with the type of receptor as well as new techniques to be utilised in detection or in therapy of disease. In conclusion, the present review underlines recent developments in this field: CCK and gastrin peptides and their receptors are the key factor of nutritional aspects; a better understanding of the mechanisms involved may increase the efficiency of the nutritional functions and the treatment of abnormalities under pathological conditions.

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“…Recently, a new indirect mechanism of CCK action on pancreatic juice secretion has been postulated in preruminant calves [146,148] as well as in pigs and rats [64,83,145] [147,149]. The presence of CCK receptors in the small intestinal mucosa has been reported in rats and ferrets [6,88].…”

Section: Effect Of Age On Digestive Productions and Enzyme Expressionsmentioning

confidence: 99%

Development of gastrointestinal and pancreatic functions in mammalians (mainly bovine and porcine species): influence of age and ingested food

Zabielski¹,

Huërou-Luron²,

Guilloteau³

1999

Reprod. Nutr. Dev.

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-This review summarizes recent advances in knowledge on the development of digestive tissues and their productions as well as mechanisms of regulation in response to age and ingested food in mammalian species (mainly bovine and porcine species). In the first two sections, changes are reported for stomach, pancreas and small intestine, and examined in relation to different situations (colostral, milk feeding and weaned periods). The implication of some regulatory substances (growth factors, gut regulatory peptides and neurohormonal substances) in regulation mechanisms is discussed over these periods. For

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Vagal afferent pathway mediates physiological action of cholecystokinin on pancreatic enzyme secretion.

Cited by 181 publications

References 25 publications

Levels of vasoactive intestinal peptide, cholecystokinin and calcitonin gene-related peptide in plasma and jejunum of rats following traumatic brain injury and underlying significance in gastrointestinal dysfunction

Levels of vasoactive intestinal peptide, cholecystokinin and calcitonin gene-related peptide in plasma and jejunum of rats following traumatic brain injury and underlying significance in gastrointestinal dysfunction

Gastrin, cholecystokinin and gastrointestinal tract functions in mammals

Development of gastrointestinal and pancreatic functions in mammalians (mainly bovine and porcine species): influence of age and ingested food

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