Vagal Nerve Stimulation: The Effect on the Brain Oscillatory Field Potential

Broncel, Adam; Bocian, Renata; Konopacki, Jan

doi:10.1016/j.neuroscience.2021.12.023

Cited by 3 publications

(3 citation statements)

References 132 publications

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Section: Introductionmentioning

confidence: 99%

“…Important to VNS’s therapeutic efficacy is its ability to induce neural desynchronization [ 7 ]. This concept has its roots in early animal studies [ 8 , 9 , 10 ] and has been further solidified by EEG connectivity studies in humans [ 7 , 11 , 12 , 13 , 14 ]. Analyses of epileptic brain structures have revealed a tendency for synchronization, suggesting heightened connectivity in malfunctioning excitatory neuronal pathways [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Vagus Nerve Stimulation (VNS) Dose-Dependent Effects on EEG Power Spectrum and Synchronization

Germany Morrison,

Danthine,

Santalucia

et al. 2024

Biomedicines

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This study investigates the dose-dependent EEG effects of Vagus Nerve Stimulation (VNS) in patients with drug-resistant epilepsy. This research examines how varying VNS intensities impacts EEG power spectrum and synchronization in a cohort of 28 patients. Patients were categorized into responders, partial-responders, and non-responders based on seizure frequency reduction. The methods involved EEG recordings at incremental VNS intensities, followed by spectral and synchronization analysis. The results reveal significant changes in EEG power, particularly in the delta and beta bands across different intensities. Notably, responders exhibited distinct EEG changes compared to non-responders. Our study has found that VNS intensity significantly influences EEG power topographic allocation and brain desynchronization, suggesting the potential use of acute dose-dependent effects to personalized VNS therapy in the treatment of epilepsy. The findings underscore the importance of individualized VNS dosing for optimizing therapeutic outcomes and highlight the use of EEG metrics as an effective tool for monitoring and adjusting VNS parameters. These insights offer a new avenue for developing individualized VNS therapy strategies, enhancing treatment efficacy in epilepsy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characterization of Vagus Nerve Stimulation (VNS) Dose-Dependent Effects on EEG Power Spectrum and Synchronization

Germany Morrison,

Danthine,

Santalucia

et al. 2024

Biomedicines

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“…Research exploring the cognitive-enhancing effects of invasive VNS used as an antiepileptic or antidepressant therapy found that VNS improved attention, arousal, short-term memory, verbal memory recognition, working memory, memory consolidation, mood, and decision-making in patients ( Clark et al, 1999 ; Sackeim et al, 2001 ; Martin et al, 2004 ; Ghacibeh et al, 2006 ; Klinkenberg et al, 2013 ; Vonck et al, 2014 ; Sun et al, 2017 ; Broncel et al, 2022 ). However, some clinical studies reported inconsistent effects of VNS on memory ( Dodrill and Morris, 2001 ; Helmstaedter et al, 2001 ; Sackeim et al, 2001 ; Klinkenberg et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Vagus nerve stimulation: mechanisms and factors involved in memory enhancement

Olsen

Solís

McIntire

et al. 2023

Front. Hum. Neurosci.

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Vagus nerve stimulation (VNS) has been recognized as a useful neuromodulation tool to target the central nervous system by electrical stimulation of peripheral nerves. Activation of the nucleus of the solitary tract (NTS) in the brainstem by vagal afferent nerve fibers allows for modulation of various higher order brain regions, including limbic and cerebral cortex structures. Along with neurological and psychiatric indications, clinical and preclinical studies suggest that VNS can improve memory. While the underlying mechanisms to improve memory with VNS involve brain areas, such as the prefrontal cortex and processes including alertness and arousal, here we focus on VNS-induced memory improvements related to the hippocampus, the main area implicated in memory acquisition. In addition, we detail research demonstrating that a targeted approach to VNS can modify memory outcomes and delve into the molecular mechanisms associated with these changes. These findings indicate that a greater understanding of VNS mechanisms while also considering stimulation parameters, administration site, timing in relation to training, and sex-specific factors, may allow for optimal VNS application to enhance memory.

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