Vaginal Colonization by Candida in Asymptomatic Women With and Without a History of Recurrent Vulvovaginal Candidiasis

Giraldo, Paulo César; Nowaskonski, Angele von; Gomes, Francis A. M.; Linhares, Iara Moreno; Neves, Neuza Maria Alcântara

doi:10.1097/00006250-200003000-00019

Cited by 30 publications

(36 citation statements)

References 15 publications

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“…Rapid MB POC tests that can produce a quick and reliable result for each single patient, and allow the initiation of specific treatment at the same health care visit are essentially needed in different clinical settings. One such setting is the diagnosis of recurrent vulvovaginal candidiasis in a patient with low-grade Candida infection that is difficult to be visualized by microscopy or discovered by culture techniques [56,96,97]. Nevertheless, both false negative and false positive results may occur.…”

Section: Indications and Future Role Of Mbmentioning

confidence: 99%

Role of Molecular Biology in Diagnosis and Characterization of Vulvo-Vaginitis in Clinical Practice

Donders¹,

Vitali

Netea

et al. 2017

Gynecol Obstet Invest

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The diagnosis of vulvo-vaginal complaints has always been enigmatic in obstetrics and gynecology. Patients with clear, pathognomonic symptoms end up with a proper diagnosis and treatment most of the time, but unfortunately we are now living in a world where women reach out to the Internet and readily get all information as to which disease their symptoms correspond to and also find the appropriate treatment “over-the-counter.” Because of this trend, we as specialists are increasingly confronted with patients with complex and combined conditions. At the same time, extremely sensitive and accurate diagnostic tools are now being developed at a rapid pace, allowing the physicians to diagnose vulvo-vaginal disease with a substantially increased precision. Moreover, many of these molecular biology (MB)-based tests have become so common and affordable that self-sampling and self-testing are no longer utopia. On the other hand, too much information that is too readily available and that is too affordable also encompasses pitfalls, leading to gross overtreatment and psychological burden. As experienced caregivers, we should supervise these evolutions, define their place and proper use as diagnostic tools, utilize their potential as ad hoc tools to follow-up treatment efficacy and guide how such tools can be used for responsible self-testing. In the present paper, responding to the need for appropriate, quality assured and accessible tests for vulvo-vaginitis and the huge potential delivered by the rapidly developing MB methods, we recommend the need for a broad and regular discussion forum, composed of both clinical and technical experts and opinion makers, in order to match the needs with the huge opportunities and ideally combine the initiatives and forces into the same direction. This forum should then translate conceived strategies into regularly updated, evidence-based national and international guidelines.

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Section: Indications and Future Role Of Mbmentioning

confidence: 99%

Role of Molecular Biology in Diagnosis and Characterization of Vulvo-Vaginitis in Clinical Practice

Donders¹,

Vitali

Netea

et al. 2017

Gynecol Obstet Invest

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“…It is important to recognize that women prone to RVVC have a higher frequency of vaginal colonization by Candida species. This may be recognized by both culture and polymerase chain reation (PCR) studies [5].…”

Section: Pathogenesismentioning

confidence: 99%

Pathogenesis of recurrent vulvovaginal candidiasis

Sobel

2002

Curr Infect Dis Rep

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Recurrent vulvovaginal candidiasis (RVVC) is by no means uncommon and is a source of considerable physical suffering, in addition to serving as a major therapeutic challenge. The syndrome is multifactorial in etiology, hence management strategies must recognize the complex etiologic pathways. Considerable progress has been made in identifying secondary causes, including biologic and host factors. Specifically, Candida microbiologic studies have revealed that azole resistance in Candida albicans is rare and infection by less sensitive non-albicans Candida species is uncommon. At least half the women with RVVC have no identifiable host or microbial predisposing factors, and an immune-based hypothesis has been generated.

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“…Risk factors such as long and wide use of antibiotics, croton drugs, immuno suppressants medicament and basic disorders such as diabetes, AIDS and malignancies caused by fungal diseases, especially increased more than in the past (Goswami et al, 2000;Merenstein et al, 2013). Vaginal yeast infections known as candidiasis, is a disease caused by growth of more yeast around genital aerea of women (Consolaro et al, 2004;Giraldo et al, 2000). This is an important disease during the years in women who are sexually acitve, and it is increasingly spreading (Hay and Ashbee, 2010).…”

Section: Introductionmentioning

confidence: 99%

Comparative study of the effect of Eucalyptus extract on Candida albicans and human pathogenic bacteria

Dehbashi¹,

Forghani²,

Sabbagh³

et al. 2017

J. Herbal Drugs

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Background & Aim: During recent decades, infections disease resulting from opportunistic fungi such as Candida albicans and resistance increasing of human pathogenic bacteria to current antibiotics has led to many problems for treating of these diseases. The aims of the present study was to investigate anti-fungi and anti-bacterial effects of Eucalyptus extract on Candida albicans species isolated from clinical samples and some standard human pathogenic bacteria. Experimental: Eucalyptus extract was provided using rotary apparatus and maceration method. Thirty isolates of Candida albicans were isolated from referred patients to gynecologist and then were purified and identified by valid keys. Finally, 30 isolated were used to growth inhibitory activity assay. Minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC) of eucalyptus extract against 5 standard bacteria inculding: Staphylococcus aureu, Shigella dysenteriae, Listeria monocytogenes, Vibrio cholera and Bacillus cereus were evaluated using micro broth dilution method. Results: Our results indicated that in compare to bacterial strains, fungus isolates showed more sensitivity to eucalyptus extract. The highest and lowest MIC of extract was recorded at 12.5 and 3.1 ppm for S. aureus and B. cereus, respectively. As MIC, the maximum MBC (20ppm) and minimum MBC (5ppm) of extract was recorded fro S. aureus and B. cereus respectively. Minimum inhibitory concentration of extract to fungal growth inhibitory was 50 ppm, whereas the maximum inhibiting concentration was 150 ppm. Recommended applications/industries: The positive and interesting results suggest the essential oil of E. globulus could be exploited antibiotic for the treatment of candidiasous disease caused by Candida albicans fungi, and some human pathogenic bacteria studied in this work. Type: Original Research Topic: Medicinal Plants

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Vaginal Colonization by Candida in Asymptomatic Women With and Without a History of Recurrent Vulvovaginal Candidiasis

Cited by 30 publications

References 15 publications

Role of Molecular Biology in Diagnosis and Characterization of Vulvo-Vaginitis in Clinical Practice

Role of Molecular Biology in Diagnosis and Characterization of Vulvo-Vaginitis in Clinical Practice

Pathogenesis of recurrent vulvovaginal candidiasis

Comparative study of the effect of Eucalyptus extract on Candida albicans and human pathogenic bacteria

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