Vaginal development during 2nd gestational trimester: translational study in human female fetuses with disorders of the neural tube

Ribeiro-Julio, Gisele Silva; Vieiralves, Rodrigo R.; Sampaio, Francisco J.B.; Gallo, C.; Favorito, Luciano A.

doi:10.1007/s00404-021-06357-4

Cited by 2 publications

(2 citation statements)

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“…Previous data from our department showed no differences in vaginal morphology, but the vaginal length and width were smaller in the anencephalic group during the second trimester of pregnancy [11]. Changes were perceived in relation to the external genitalia, with anencephalic fetuses tending to have more rudimentary external genitalia, with a reduction in anatomical distances from some reference points: length and width of the clitoris, length and width of the vaginal introitus, and distance between the labia majora and the clitoris-anus distance.…”

Section: Discussioncontrasting

confidence: 54%

“…Recently, the urogenital tract of anencephalic fetuses has been studied, including the kidneys and collecting system [2,3], ureters [4], bladder [5], prostate [6,7], penis [8], testicles [9], female external genitalia [10] and vagina [11]. Some authors have indicated a different response of male and female anencephalic fetuses to hormonal stimulation [12].…”

Section: Introductionmentioning

confidence: 99%

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Neural Tube Defects and Uterus Development in Human Fetuses

Diniz

Vieiralves

Sampaio

et al. 2022

Preprint

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Purpose: One of the most common malformations of the central nervous system is related to embryonic neural tube alterations. We hypothesized that anencephaly affects the development of the uterus during the human second trimester of pregnancy. The objective of this study was to study the biometric parameters of the uterus in fetuses with anencephaly and compare them with normocephalic fetuses at that important.Methods: In our study, 34 female fetuses were analyzed, 22 normal and 12 anencephalic, aged between 12 and 22 weeks post-conception (WPC). After dissection of the pelvis and individualization of the genital tract, we evaluated the length and width of the uterus using the Image J software. We compared the means statistically using the Wilcoxon-Mann-Whitney test and performed linear regression.Results: We do not identify statistical significance between the groups for the measurements of uterus length (Control: 2.02-6.36mm/mean=3.59mm/SD+-1.43 vs. Anencephalic: 1.71-5.44mm/mean=2.97mm/SD+-1.21, p=0.1070) and uterus width (Control: 1.99-7.91mm/mean= 3.84mm/SD+- 1.27 vs. Anencephalic: 2.08-6.48mm/mean= 3.65mm/SD +- 1.23; p =0.3360). The linear regression analysis indicated that 80% significance was found in the correlations in normocephalic fetuses (12.9 to 22.6 WPC) and 40% significance in anencephalic fetuses (12.3 to 18.6 WPC). Conclusions: We do not find statistical differences in the length and width of the uterus in anencephalic fetuses compared to the control group but uterine length and width shows a lesser tendency to growth in the anencephalic fetuses during the second trimester suggesting that anencephaly can impact the development of the uterus.

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Section: Discussioncontrasting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Neural Tube Defects and Uterus Development in Human Fetuses

Diniz

Vieiralves

Sampaio

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Neural tube defects and uterus development in human fetuses

Diniz

Vieiralves

Sampaio

et al. 2022

Sci Rep

View full text Add to dashboard Cite

One of the most common malformations of the central nervous system is related to embryonic neural tube alterations. We hypothesized that anencephaly affects the development of the uterus during the human second trimester of pregnancy. The objective of this study was to study the biometric parameters of the uterus in fetuses with anencephaly and compare them with normocephalic fetuses at that important. In our study, 34 female fetuses were analyzed, 22 normal and 12 anencephalic, aged between 12 and 22 weeks post-conception (WPC). After dissection of the pelvis and individualization of the genital tract, we evaluated the length and width of the uterus using the Image J software. We compared the means statistically using the Wilcoxon-Mann–Whitney test and performed linear regression. We identify significant differences between the uterus length (mm)/weight (g) × 100 (p = 0.0046) and uterus width (mm)/weight (g) × 100 (p = 0.0013) when we compared the control with the anencephalic group. The linear regression analysis indicated that 80% significance was found in the correlations in normocephalic fetuses (12.9 to 22.6 WPC) and 40% significance in anencephalic fetuses (12.3 to 18.6 WPC). The measurements of the uterus were greater in anencephalic group but there are no difference in the uterine width and length growth curves during the period studied. Further studies are required to support the hypothesis suggesting that anencephaly may affect uterine development during the human fetal period.

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Vaginal development during 2nd gestational trimester: translational study in human female fetuses with disorders of the neural tube

Cited by 2 publications

References 20 publications

Neural Tube Defects and Uterus Development in Human Fetuses

Neural Tube Defects and Uterus Development in Human Fetuses

Neural tube defects and uterus development in human fetuses

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