Vagus Nerve Stimulation for the Treatment of Heart Failure

Sabbah, Hani N.

doi:10.1016/b978-0-323-44733-1.00135-8

Cited by 1 publication

(2 citation statements)

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“…Abnormalities in the functioning of the autonomic nervous system, such as sustained sympathetic overdrive and parasympathetic withdrawal, are some of the characteristic features of heart failure (HF). In HF, due to sympathovagal imbalance, the heart rate increases, there is excessive release of pro-inflammatory cytokines, dysregulation of nitric oxide pathways, and arrythmias ( Sabbah, 2018 ). Studies reported that alteration in cardiac vagal efferent activity could decrease heart rate and improve ventricular contractile function, thus paving the way for electrical cervical VNS therapy to prevent sudden cardiac death and improve long-term survival ( Sabbah, 2018 ).…”

Section: Neuromodulating Devicesmentioning

confidence: 99%

“…In HF, due to sympathovagal imbalance, the heart rate increases, there is excessive release of pro-inflammatory cytokines, dysregulation of nitric oxide pathways, and arrythmias ( Sabbah, 2018 ). Studies reported that alteration in cardiac vagal efferent activity could decrease heart rate and improve ventricular contractile function, thus paving the way for electrical cervical VNS therapy to prevent sudden cardiac death and improve long-term survival ( Sabbah, 2018 ). Right cervical vagus nerve-based implants for VNS have been tested clinically for the treatment of congestive heart failure.…”

Section: Neuromodulating Devicesmentioning

confidence: 99%

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Neurosensory Prosthetics: An Integral Neuromodulation Part of Bioelectronic Device

2021

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Bioelectronic medicines (BEMs) constitute a branch of bioelectronic devices (BEDs), which are a class of therapeutics that combine neuroscience with molecular biology, immunology, and engineering technologies. Thus, BEMs are the culmination of thought processes of scientists of varied fields and herald a new era in the treatment of chronic diseases. BEMs work on the principle of neuromodulation of nerve stimulation. Examples of BEMs based on neuromodulation are those that modify neural circuits through deep brain stimulation, vagal nerve stimulation, spinal nerve stimulation, and retinal and auditory implants. BEDs may also serve as diagnostic tools by mimicking human sensory systems. Two examples of in vitro BEDs used as diagnostic agents in biomedical applications based on in vivo neurosensory circuits are the bioelectronic nose and bioelectronic tongue. The review discusses the ever-growing application of BEDs to a wide variety of health conditions and practices to improve the quality of life.

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Section: Neuromodulating Devicesmentioning

confidence: 99%

Section: Neuromodulating Devicesmentioning

confidence: 99%