Validated Stability-Indicating UPLC and Derivative Synchronous Fluorescence Spectroscopy Methods for the Determination of Atomoxetine Hydrochloride in Pharmaceutical Preparation

Soliman, Suzan M.; El-Agizy, Heba M.

doi:10.4172/2153-2435.1000278

Cited by 6 publications

(3 citation statements)

References 13 publications

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“…The most prevalent neurobehavioral condition of childhood is ADHD, and some individuals’ symptoms last into adulthood. It is characterised by signs of impulsivity, hyperactivity, and inattentiveness that interfere with academic and social performance [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

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A novel spectrophotometric approach relies on a charge transfer complex between atomoxetine with quinone-based π-acceptor. Application to content uniformity test

Abu‐hassan

2023

BMC Chemistry

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Atomoxetine (ATO) belongs to psychoanaleptic drugs and is utilized in attention-deficit hyperactivity syndrome treatment. In this study, two facile and selective approaches are implemented for the spectrophotometric analysis of atomoxetine. The two approaches rely on charge transfer formed between ATO base (n-donor) with p-chloranil and 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ; π-acceptor). The generated complexes exhibit absorption intensity maxima at 550 and 460 nm in acetonitrile for p-chloranil and DDQ in the order. Under the optimum reaction condition, Beer’s law was followed for p-chloranil and DDQ at concentrations of 30–320 and 10–80 µg mL− 1, respectively. The ICH guidelines were followed for work validation, and the outcomes were excellent and satisfactory. The assessment of ATO in pharmaceutical capsules using the suggested procedures was successful, and the results were contrasted with those obtained using a different published method to show accuracy and precision. Additionally, the two methods were used to assess the homogeneity of ATO content in the commercialized capsule.

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Section: Introductionmentioning

confidence: 99%

“…Several strategies have been reported for ATO assay. Among these methods are spectrophotometry [ 3 – 5 ], spectrofluorimetry [ 2 , 6 ], liquid chromatography [ 7 – 10 ], capillary electrophoresis [ 11 ] and electrochemical method [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

A novel spectrophotometric approach relies on a charge transfer complex between atomoxetine with quinone-based π-acceptor. Application to content uniformity test

Abu‐hassan

2023

BMC Chemistry

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“…Therefore, the development of techniques which allow the direct determination of mixtures of fluorescent compounds through the careful selection of instrumental variables is of great interest. Among these techniques, the most popular is synchronous and derivative fluorescence spectrometry (4)(5)(6)(7)(8)(9). The application of derivative techniques to luminescence spectrometry generates spectra having decreased bandwidths and enhances minor spectral features, thus improving the selectivity of multicomponent spectra.…”

Section: Introductionmentioning

confidence: 99%

Derivative emission spectrofluorimetry: Application to the analysis of newly approved FDA combination of ibuprofen and famotidine in tablets

Ragab

El-Kimary

2014

Luminescence

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A new combination of ibuprofen (NSAID) and famotidine (H2 receptor antagonist) was recently approved by the FDA. It was formulated to relief pain while decreasing the risk of ulceration, which is a common problem for patients receiving NSAID. A rapid and simple derivative emission spectrofluorimetric method is proposed for the simultaneous analysis of this combination in their pharmaceutical preparation. The method is based upon measurement of the native fluorescence intensity of the two drugs at λex = 233 nm in acetonitrile. The emission data were differentiated using the first (D1) derivative technique. The plots of derivative fluorescence intensity versus concentration were rectilinear over a range of 2-35 and 0.4-8 µg/mL for both ibuprofen (IBU) and famotidine (FAM), respectively. The method was sensitive as the limits of detection were 0.51 and 0.12 µg/mL and limits of quantitation were 1.70 and 0.39 µg/mL, for IBU and FAM respectively. The proposed derivative emission spectrofluorimetric method was successfully applied for the determination of the two drugs in their synthetic mixtures and tablets with good accuracy and precision. The proposed method was validated as per ICH guidelines.

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Microwave-assisted heating: innovative use in hydrolytic forced degradation of selected drugs

Patel

Mehta

2017

Journal of Microwave Power and Electromagnetic Energy

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Validated Stability-Indicating UPLC and Derivative Synchronous Fluorescence Spectroscopy Methods for the Determination of Atomoxetine Hydrochloride in Pharmaceutical Preparation

Cited by 6 publications

References 13 publications

A novel spectrophotometric approach relies on a charge transfer complex between atomoxetine with quinone-based π-acceptor. Application to content uniformity test

A novel spectrophotometric approach relies on a charge transfer complex between atomoxetine with quinone-based π-acceptor. Application to content uniformity test

Derivative emission spectrofluorimetry: Application to the analysis of newly approved FDA combination of ibuprofen and famotidine in tablets

Microwave-assisted heating: innovative use in hydrolytic forced degradation of selected drugs

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