Validating layer-specific VASO across species

Huber, Laurentius; Poser, Benedikt A.; Kaas, Amanda L.; Fear, Elizabeth J.; Dresbach, Sebastian; Berwick, Jason; Goebel, Rainer; Turner, Robert; Kennerley, Aneurin J.

doi:10.1016/j.neuroimage.2021.118195

Cited by 15 publications

(13 citation statements)

References 111 publications

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“…Careful calibration of the T 2 ‐bandwidth of the saturation though may better target specific compartments of the venous vasculature. Additionally, we did not attempt a comparison with more established layer‐resolving fMRI techniques, the specificity of which has been confirmed with contrast‐enhanced fMRI (Huber, Poser, Kaas, et al, 2021 ; Jin & Kim, 2008 ). In the future, this is needed to validate the spatial specificity of ABC.…”

Section: Discussionmentioning

confidence: 99%

Combining arterial blood contrast with BOLD increases fMRI intracortical contrast

Priovoulos

Oliveira

Poser

et al. 2023

Human Brain Mapping

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BOLD fMRI is widely applied in human neuroscience but is limited in its spatial specificity due to a cortical‐depth‐dependent venous bias. This reduces its localization specificity with respect to neuronal responses, a disadvantage for neuroscientific research. Here, we modified a submillimeter BOLD protocol to selectively reduce venous and tissue signal and increase cerebral blood volume weighting through a pulsed saturation scheme (dubbed Arterial Blood Contrast) at 7 T. Adding Arterial Blood Contrast on top of the existing BOLD contrast modulated the intracortical contrast. Isolating the Arterial Blood Contrast showed a response free of pial‐surface bias. The results suggest that Arterial Blood Contrast can modulate the typical fMRI spatial specificity, with important applications in in‐vivo neuroscience.

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Section: Discussionmentioning

confidence: 99%

Combining arterial blood contrast with BOLD increases fMRI intracortical contrast

Priovoulos

Oliveira

Poser

et al. 2023

Human Brain Mapping

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“…However, the echo-planar readout employed in such studies still contributes to significant large vein contamination as it contains a significant GRE component in addition to the SE term. In recent years, the use of vascular-space-occupancy (VASO) fMRI (Lu et al, 2003) in laminar studies has generated significant interest (Bandettini et al, 2021;Beckett et al, 2020;Chai et al, 2019;Finn et al, 2019;Guidi et al, 2016Guidi et al, , 2020Huber et al, 2014bHuber et al, , 2015Huber et al, , 2016aHuber et al, , 2016bHuber et al, , 2017aHuber et al, , 2021bKashyap et al, 2018). VASO is a T1 contrast that reflects the extra-vascular tissue signal reduction that occurs as a consequence of the cerebral blood volume (CBV) increase following neuronal activity.…”

Section: Introductionmentioning

confidence: 99%

Layer Dependence of Monocular and Binocular Responses in Human Ocular Dominance Columns at 7T using VASO and BOLD

Akbari

Gati

Zeman³

et al. 2023

Preprint

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The neurons located in the striate cortex (V1) preferentially respond to the input from one eye or another, forming a fingerprint-like pattern of ocular dominance columns (ODCs). At this mesoscopic scale, accessible by ultra-high field fMRI, V1 is supplied/drained by a network of surface (pial) vessels that connect to descending/ascending tangential vessels that penetrate the cortex and supply/drain a capillary bed whose density is also layer dependent. In this study, we measured the layer dependence of monocular and binocular responses of ocular dominance columns in V1 at 7T using Blood Oxygenation Level Dependent (BOLD) and VAscular Space Occupancy (VASO) contrasts. Our results indicate that the microvascular blood volume changes that give rise to VASO are well confined to the site of neural activity across the layers of the cortex and between the columns. Pial veins dominate the BOLD response and mix the signal between columns. When the GRE BOLD response was examined in only the VASO-specific voxels (thus eliminating the pial vein signal), the laminar profile was very similar to VASO, however, the columnar response was still blurred. Caution needs to be exercised in the interpretation of signal changes in BOLD at the mesoscale both in terms of feedforward/feedback effects and inhibitory and excitatory effects.

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“…8,16,17 Alternatively, the longitudinal component of blood water magnetization can be suppressed using principles of inversion recovery with the vascular-space-occupancy (VASO) technique. [18][19][20][21] VASO uses an inversion pre-pulse with an inversion time (TI) chosen to null the longitudinal component of blood water magnetization at the time of excitation. A similar module may be played before the ASE sequence in a proposed VASO-ASE approach.…”

Section: Introductionmentioning

confidence: 99%

Vascular space occupancy asymmetric spin echo (VASO‐ASE) for non‐invasive quantification of cerebral oxygen extraction fraction

Waddle

Garza

Ying

et al. 2023

Magnetic Resonance in Med

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Purpose Asymmetric spin echo (ASE) MRI is a method for measuring regional oxygen extraction fraction (OEF); however, extravascular tissue models have been shown to under‐estimate OEF. The hypothesis investigated here is that the addition of a vascular‐space‐occupancy (VASO) pre‐pulse will more fully suppress blood water signal and provide global OEF values more consistent with physiological expectation and 15O positron emission tomography (PET)‐validated T2‐relaxation‐under‐spin‐tagging (TRUST) OEF measures. Methods Healthy adults (n = 14; age = 27.7 ± 5.2 y; sex = 7/7 male/female) were scanned at 3.0T. Multi‐echo ASE without inter‐readout refocusing (ASERF−), multi‐echo ASE with inter‐readout refocusing (ASERF+), and single‐echo VASO‐ASE were acquired twice each with common spatial resolution = 3.44 × 3.44 × 3.0 mm and τ = 0–20 ms (interval = 0.5 ms). TRUST was acquired twice sequentially for independent global OEF assessment (τCPMG = 10 ms; effective TEs = 0, 40, 80, and 160 ms; spatial resolution = 3.4 × 3.4 × 5 mm). OEF intraclass‐correlation‐coefficients (ICC), summary statistics, and group‐wise differences were assessed (Wilcoxon rank‐sum; significance: two‐sided p < 0.05). Results ASERF+ (OEF = 36.8 ± 1.9%) and VASO‐ASE (OEF = 34.4 ± 2.3%) produced OEF values similar to TRUST (OEF = 36.5 ± 4.6%, human calibration model; OEF = 32.7 ± 4.9%, bovine calibration model); however, ASERF− yielded lower OEF (OEF = 26.1 ± 1.0%; p < 0.01) relative to TRUST. VASO‐ASE (ICC = 0.61) yielded lower ICC compared to other ASE variants (ICC >0.89). Conclusion VASO‐ASE and TRUST provide similar OEF values; however, VASO‐ASE spatial coverage and repeatability improvements are required.

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Validating layer-specific VASO across species

Cited by 15 publications

References 111 publications

Combining arterial blood contrast with BOLD increases fMRI intracortical contrast

Combining arterial blood contrast with BOLD increases fMRI intracortical contrast

Layer Dependence of Monocular and Binocular Responses in Human Ocular Dominance Columns at 7T using VASO and BOLD

Vascular space occupancy asymmetric spin echo (VASO‐ASE) for non‐invasive quantification of cerebral oxygen extraction fraction

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