Validation and agreement across four versions of the asthma control questionnaire in patients with persistent asthma

Wyrwich, Kathleen W.; Khan, Sajjad; Navaratnam, Prakash; Nolte, Hendrik; Gates, Davis

doi:10.1016/j.rmed.2010.11.004

Cited by 19 publications

(29 citation statements)

References 18 publications

(21 reference statements)

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“…13,14,19 The correlations between the ACQ and the shortened versions were high (r ϭ 0.87 with ACQ-5, 0.98 with ACQ6a, and 0.92 with ACQ-6b). 57 A post hoc analysis of 2 large clinical trials showed that all versions of the ACQ were strongly correlated with each other and with the overall score from the AQLQ for both baseline and change scores. 57 In another study, Juniper et al 58 reported that these 3 shortened versions can be used in large clinical trials without loss of validity or change in interpretation.…”

Section: Validitymentioning

confidence: 99%

“…57 A post hoc analysis of 2 large clinical trials showed that all versions of the ACQ were strongly correlated with each other and with the overall score from the AQLQ for both baseline and change scores. 57 In another study, Juniper et al 58 reported that these 3 shortened versions can be used in large clinical trials without loss of validity or change in interpretation. Also, when the 4 versions were compared with each other, substantial concordances in both cross-sectional and longitudinal va-lidity were noted.…”

Section: Validitymentioning

confidence: 99%

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Asthma Control Assessment Tools

Alzahrani

Becker

2015

Respir Care

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, and they emphasize periodic assessment of asthma control once treatment is established. Accurate assessment of asthma control is difficult due to the complexity of asthma control and due to the limitations in the traditional methods of assessment, such as lung function tests, physician assessment, and patients' self-assessment. Relying solely on the role of lung function tests is insufficient to reflect the status of asthma control, since patients with asthma may have normal spirometry between exacerbations. Clinicians often overestimate the level of asthma control. Similarly, it is not uncommon for patients to overestimate how well their asthma is controlled, and, therefore, they under-report asthma symptoms and fail to recognize the impact that asthma has on their daily life. As a result, several tools have been developed to quantify the level of asthma control, identify patients at risk, and evaluate the effect of asthma management. This review examines the commonly 106RESPIRATORY CARE • JANUARY 2016 VOL 61 NO 1 used asthma control assessment tools in terms of content, psychometric properties, methods of administration, limitations, and ability to reflect the overall status of asthma control, which can aid clinicians in selecting the most appropriate tool for their needs.

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Section: Validitymentioning

confidence: 99%

Section: Validitymentioning

confidence: 99%

Asthma Control Assessment Tools

Alzahrani

Becker

2015

Respir Care

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“…The overall score is the average of the individual item scores, ranging from 0 (totally controlled) to 6 (severely uncontrolled). Abbreviated versions of the ACQ are also available: the ACQ-5, which scores symptoms only, that is, omits bronchodilator use and FEV 1 , and the ACQ-6, which scores symptoms and bronchodilator use (25,26).…”

Section: Overview Of the Acqmentioning

confidence: 99%

The Asthma Control Questionnaire as a clinical trial endpoint: past experience and recommendations for future use

Barnes¹,

Casale

Dahl

et al. 2014

Allergy

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The goal of asthma treatment is to control the disease according to guidelines issued by bodies such as the Global Initiative for Asthma. Effective control is dependent upon evaluation of symptoms, initiation of appropriate treatment and minimization of the progressive adverse effects of the disease and its therapies. Although individual outcome measures have been shown to correlate with asthma control, composite endpoints are preferred to enable more accurate and robust monitoring of the health of the individual patient. A number of validated instruments are utilized to capture these component endpoints; however, there is no consensus on the optimal instrument for use in clinical trials. The Asthma Control Questionnaire (ACQ) has been shown to be a valid, reliable instrument that allows accurate and reproducible assessment of asthma control that compares favourably with other commonly used instruments. This analysis provides a summary of the use of ACQ in phase II, III and IV asthma trials. Comparisons between the ACQ and other instruments are also presented. Our analysis suggests that the ACQ is a valid and robust measure for use as a primary or secondary endpoint in future clinical trials.

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“…For determining the control level, 2 threshold values were described. The mark ≤0,75 points means that BA is controlled, and the value ≥1,5 -uncontrolled [11]. The interval from 0,75 to 1,5 -so-called "grey zone", from our point of view, it may be assessed as a partial control of asthma.…”

Section: Introductionmentioning

confidence: 99%

“…The data of independent studies give proofs about validity of the questionnaire for BA control, and the possibility of its use in the general practice and for clinical studies [11,12]. The questionnaire includes questions about BA symptoms, use of bronchodilators with a short-term action (ACQ-6), and also the volume of a forced exhalation for 1 second (FEV1) (ACQ-7) [13].…”

Section: Introductionmentioning

confidence: 99%

Control Level and Assessment of the Clinical Course in Patients With the Associated Pathology of Bronchial Asthma and Copd

Feshchenko¹,

Nazarenko²

2017

EUREKA: Health Sciences

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The notion “asthma-COPD cross” (ACC) for patients with clinical signs of bronchial asthma and COPD was introduced. From 15 to 45 % of population with bronchial obstructive diseases suffer from ACC and its prevalence increases with age. According to the data of epidemiological studies, in average a half of patients with BA in the world cannot reach a control of BA or keep it for a long time. The aim of our research was the determination of the control level and also assessment of symptoms of the disease of patients with BA and COPD. Patients. The study included patients with ACC, older than 30 years. The control included patients with the bronchial asthma and COPD without any signs of these pathologies combination. Methods. All patients underwent the spirography with the analysis of the curve “flow-volume” of a force exhalation and also bodypletizmography (“MasterScreenPneumo”, "CardinalHealth" (Germany)). Al patients were interrogated by the questionnaires: questionnaire for BA symptoms control (ACQ-7), test for BA control (ACT), test for COPD assessment CAT). Results. At comparing parameters of BA control was revealed the reliably worse control in the group of patients with the associated pathology by data of the questionnaire ACQ-7 comparing with patients with BA. The influence of COPD symptoms was also more essential in patients with ACC comparing with one with COPD. At the more expressed degree of the bronchial obstruction, BA control was reliably weaker, whereas the influence of COPD symptoms was more essential. In patients with ACC with the unsatisfactory control of BA (АСQ-7 ≥1,5 points) the mortality prognosis, expressed by BODE index, grows almost in 3 times; inpatients with the severe and very severe influence of the disease effect (САТ > 20 points), the mortality prognosis grows more than in 2 times. The reliable positive correlation was revealed between the results of CAT and ratio of the internal thoracic volume of gases to the total capacity of lungs (ITGV/TLС), that reflects the degree of lungs hyperinflation - (r=0,35; p<0,05). Conclusions. At BA and COPD combination the indices of the disease control are worse than at the bronchial asthma and a bit similar to ones at COPD. Indices of BA control and influence of COPD symptoms on the condition of patients with the associated pathology were mainly negatively changed at the increase of the bronchial obstruction degree. The essential negative influence of the insufficient BA control and the high influence of COPD symptoms on the disease prognosis in patients with associated pathology (BA+COPD) were revealed.

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Validation and agreement across four versions of the asthma control questionnaire in patients with persistent asthma

Abstract: All ACQ versions have similar and strong psychometric properties. Classifications of change over time using the original ACQ and a six-item version without SABA use provided generally fair to moderate agreement with the international guidelines criteria for asthma control.

Cited by 19 publications

References 18 publications

Asthma Control Assessment Tools

Asthma Control Assessment Tools

The Asthma Control Questionnaire as a clinical trial endpoint: past experience and recommendations for future use

Control Level and Assessment of the Clinical Course in Patients With the Associated Pathology of Bronchial Asthma and Copd

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