1980
DOI: 10.1016/0165-1110(80)90002-0
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Validation and comparative studies on 180 chemicals with S. typhimurium strains and V79 Chinese hamster cells in the presence of various metabolizing systems

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Cited by 249 publications
(49 citation statements)
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“…Therefore, chemical analyses in this study were limited to 16 PAHs, most of them are biologically active [20][21][22][23] or even carcinogenic [6]. The seasonal and spatial pattern of these 16 PAHs was investigated.…”
Section: Discussionmentioning
confidence: 99%
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“…Therefore, chemical analyses in this study were limited to 16 PAHs, most of them are biologically active [20][21][22][23] or even carcinogenic [6]. The seasonal and spatial pattern of these 16 PAHs was investigated.…”
Section: Discussionmentioning
confidence: 99%
“…Indirect-acting mutagenicity is usually attributed to PAHs [20], since these compounds need metabolic activation in order to exert effect. Next to the indirect-acting compounds other chemicals like nitro-PAHs and oxy-PAHs have direct mutagenic effect and do not need any metabolic activation [38].…”
Section: Discussionmentioning
confidence: 99%
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“…Only the highest concentration resulted in a result statistically significantly different from control (1.2-fold increase only). A second experiment was not EFSA Journal 2011; 9(5):1990 (Bartsch et al, 1980) As only two strains were used the quality of the study must be considered insufficient for the purpose of this Flavouring Group Evaluation Validity cannot be evaluated as details of the result were not reported. Negative 17.…”
Section: Annex Iv: Toxicitymentioning
confidence: 99%
“…In rats, the activity was low, and hepatic microsomes from hamster showed the highest activity, although there was no appreciable difference between the sexes. Therefore, S-9 mixes obtained from several species are an important factor for the efficient detection of mutagenicityr [8,9].…”
Section: Introductionmentioning
confidence: 99%