Validation and comparison of imaging-based scores for prediction of early stroke risk after transient ischaemic attack: a pooled analysis of individual-patient data from cohort studies

Abstract

Health Research Board of Ireland, Irish Heart Foundation, Irish Health Service Executive, Irish National Lottery, National Medical Research Council of Singapore, Swiss National Science Foundation, Bangerter-Rhyner Foundation, Swiss National Science Foundation, Swisslife Jubiläumsstiftung for Medical Research, Swiss Neurological Society, Fondazione Dr Ettore Balli (Switzerland), Clinical Trial Unit of University of Bern, South Korea's Ministry for Health, Welfare, and Family Affairs, UK Wellcome Trust, Wolfson Foundation, UK Stroke Association, British Heart Foundation, Dunhill Medical Trust, National Institute of Health Research (NIHR), Medical Research Council, and the NIHR Oxford Biomedical Research Centre.

Contemporary Epidemiology of Transient Ischemic Attack in Dijon, France (2013–2015)

“…The distribution of ABCD 2 score was consistent with that observed in other large cohort studies [18, 26]. A large proportion of TIA patients had a high risk of recurrence.…”

“…Only 23% of TIA patients had a brain MRI, and among these, 15.5% had an infarct lesion corresponding to the event. This rate is lower than that reported in a recently published pooled analysis of TIA cohort studies (31%) [18], probably because in our setting, MRI was performed from hours to days after symptom onset, and it has been shown that the probability of detecting a lesion on MRI depends on the timing of the imaging procedure [19, 20]. It is noteworthy that the detection of an infarct lesion with CT scan was even lower (2.4% of patients).…”

Prediction of stroke risk in patients with transient ischemic attack: ABCD score and its derived scores

“…Results showed that high ABCD score indicates high incidence of stroke within 30 d. ABCD score reached 0-2, 3, 4, 5, and 6 with risks of stroke reaching 0%, 3.5%, 7.6%, 21.3% and 31.3% respectively; at the same time, ABCD score of 5-6 points within 30 d stroke risk is eight times higher than that of ABCD score of 4 points or less. 8,9 The study suggests good clinical use of this score to predict reliability of the risk of stroke after TIA. ABCD score can identify high risk of stroke patients at an early period.…”

“…8 ABCD score of 6points (approximately 30% within 7d stroke incidence) in the acute phase must be observed in hospital settings. In the event of stroke, clinicians can timely apply thrombolysis therapy.…”

“…2,8,9,11,22 In 2010, researchers established ABCD3 and ABCD3I score. 15 Which on the basis of the ABCD2 added an index in ABCD3: double TIA (TIA attack 2 times or more within 7 days, 2points), the total score nine points; ABCD3I score increased three indicators (double TIA, ipsilateral carotid stenosis, positive DWI), a total of eight items: age 60 years or more (1 point), blood pressure >140/90 MMHG (1 point), clinical symptoms (words damaged 1 points; partial side limb weakness 2 points), duration of symptoms (10-59 minutes 1point; 2 minutes and 60 minutes or higher), diabetes (1 point), double TIA, carotid stenosis and positive DWI (2 points), and all score of 13 points.…”