Validation and optimization of a membrane system for carbon dioxide removal in anesthesia circuits under realistic patient scenarios

Wilfart, Florentin M.; McNeil, Megan V.; Haelssig, Jan B.; Hanafi, Hamed; Roach, David C.; Maksym, Geoffrey N.; Schmidt, M

doi:10.1016/j.memsci.2020.117887

Cited by 5 publications

(6 citation statements)

References 33 publications

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“…The key point in its longterm application is to enhance the property of membrane materials, and oxygen exchange efficiency is a vital indicator for evaluating the property of membrane materials. After decades of research progress, it is gradually developed into hollow fiber membrane material prepared by PP or PMP, which can meet the requirements of oxygen exchange for blood oxygenation [132][133][134][135][136].…”

Section: Conclusion and Prospectmentioning

confidence: 99%

Modification strategies to improve the membrane hemocompatibility in extracorporeal membrane oxygenator (ECMO)

Wang

et al. 2021

Adv Compos Hybrid Mater

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Since extracorporeal membrane oxygenator (ECMO) has been utilized to save countless lives by providing continuous extracorporeal breathing and circulation to patients with severe cardiopulmonary failure. In particular, it has played an important role during the COVID-19 epidemic. One of the important composites of ECMO is membrane oxygenator, and the core composite of the membrane oxygenator is hollow fiber membrane, which is not only a place for blood oxygenation, but also is a barrier between the blood and gas side. However, the formation of blood clots in the oxygenator is a key problem in the using process. According to the study of the mechanism of thrombosis generation, it was found that improving the hemocompatibility is an efficient approach to reduce thrombus formation by modifying the surface of materials. In this review, the corresponding modification methods (surface property regulation, anticoagulant grafting, and bio-interface design) of hollow fiber membranes in ECMO are classified and discussed, and then, the research status and development prospects are summarized. Graphical abstract

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Section: Conclusion and Prospectmentioning

confidence: 99%

Modification strategies to improve the membrane hemocompatibility in extracorporeal membrane oxygenator (ECMO)

Wang

et al. 2021

Adv Compos Hybrid Mater

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“…Membranebased technology has been addressed as an alternative methodology for the recycling of the inhalational anaesthetics. The investigated alternatives included the use of membrane contactors for CO2 absorption with a reactive liquid phase [26], hollow fibre contactors [5,27], carbon molecular sieve membranes [6,28], immobilized liquid membranes [3] and zeolite membranes [29]. Membrane contactors provide a non-dispersive, fixed and well-determined interface for gasliquid mass transfer, where instead of selectivity, the membrane offers a barrier to separate the two phases, while the selectivity is given by the liquid phase (although it is possible to use selective membranes).…”

Section: Background and Motivationmentioning

confidence: 99%

“…In this case, miniaturization of the module, that requires a reduced amount of the choliniumbased ionic liquids, and the high CO2 permeability of PDMS membrane, were exploited. Regarding the second configuration, a hydrophobic microporous polytetrafluoroethylene (PTFE) membrane was considered as a highly chemically resistant material, since PTFE membranes are capable to retain their non-wetting behaviour [27]. The commercially available Eclipse™ membranes were selected for the present study.…”

Section: Background and Motivationmentioning

confidence: 99%

“…Membrane-based technology has been proposed as a possible alternative for the recycling of the inhalational anaesthetics. The investigated alternatives included the use of membrane contactors for CO2 absorption with a reactive liquid phase [108,124,164], hollow fibre contactors [5,27], carbon molecular sieve membranes [6], immobilized liquid membranes [3] and zeolite membranes [29].…”

Section: Introductionmentioning

confidence: 99%

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CO2 removal from anaesthesia circuits using gas-ionic liquid membrane contactors

Martins

Neves

Chagas

et al. 2020

Separation and Purification Technology

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“…To prevent the accumulation of CO 2 , soda lime is used to absorb CO 2 . Alternative methods to remove expired CO 2 has attracted much research, including using new absorbents or membrane separation. − As one example, 13× molecular sieves have been shown to be effective CO 2 absorbers, without the formation of harmful byproducts . Similarly, Wilfart et al recently studied a membrane-based device to remove CO 2 from anesthesia circuits using a sweep gas.…”

Section: Introductionmentioning

confidence: 99%

Recovery of Sevoflurane Anesthetic Gas Using an Organosilica Membrane in Conjunction with a Scavenging System

Liu

McGain

Kentish

2021

Environ. Sci. Technol.

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Approximately 95% of the anesthetic gas administered to a patient is exhaled and ultimately released to the atmosphere. Most anaesthetic gases have high global warming potential and so this approach adds significantly to the global greenhouse gas footprint. In this work we develop a feasible means to capture such an anaesthetic gas (sevoflurane) before it is released to the hospital scavenging system, so that it is retained within the anaesthetic circuit. Sevoflurane is retained using a microporous 1,2bis(triethoxysilyl)ethane (BTESE) membrane prepared by a sol-gel method. The use of a ceramic membrane facilities sanitisation at high temperatures. A rapid thermal processing (RTP) technique is employed to reduce production time and to create a looser organosilica network, resulting in higher gas permeances, compared with the membrane synthesized from conventional thermal processing (CTP).The RTP membrane shows a slight decline in gas permeance when used with a dry mixture of CO2/N2/sevoflurane. This permeance falls again under 20% relative humidity feed conditions but the CO2/sevoflurane selectivity increases. The membrane performance shows little variation when the relative humidity is further increased. These promising results demonstrate that this microporous BTESE membrane has great potential for the recovery of sevoflurane in an anaesthetic application.

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Validation and optimization of a membrane system for carbon dioxide removal in anesthesia circuits under realistic patient scenarios

Cited by 5 publications

References 33 publications

Modification strategies to improve the membrane hemocompatibility in extracorporeal membrane oxygenator (ECMO)

Modification strategies to improve the membrane hemocompatibility in extracorporeal membrane oxygenator (ECMO)

CO2 removal from anaesthesia circuits using gas-ionic liquid membrane contactors

Recovery of Sevoflurane Anesthetic Gas Using an Organosilica Membrane in Conjunction with a Scavenging System

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