Validation and optimization of adiabatic T_1ρ and T_2ρ for quantitative imaging of articular cartilage at 3 T

Abstract

The findings indicate that sequences are suitable for quantitative in vivo assessment of articular cartilage at 3 T. Magn Reson Med 77:1265-1275, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Elevated adiabatic T1ρ and T2ρ in articular cartilage are associated with cartilage and bone lesions in early osteoarthritis: A preliminary study

“…Interestingly, the Ad T 1ρ and Ad T 2ρ values in the superficial layers were constantly longer than those previously reported for younger asymptomatic adults (age range 25–35 years) . On the contrary, values in the deep layers were more consistent between the groups.…”

“…In patients, the knee with clinical signs of OA (or with greater KL score in case of subjects with symptoms in both knees) was imaged, while in volunteers the knee was chosen at random. The protocol included six sequences: Proton density (PD)‐weighted (PD‐w) turbo spin echo (TSE), fat‐suppressed (FS) PD‐w SPACE, T 1 ‐weighted TSE, T 2 mapping, Ad T 1ρ and Ad T 2ρ mapping . The imaging parameters of each sequence are listed in Table .…”

“…Reduced sensitivity to the magic angle effect of adiabatic T 1ρ has also been reported compared to T 2 and conventional CW‐ T 1ρ . Ad T 1ρ and Ad T 2ρ have already been optimized for AC imaging in the clinical environment and have shown good to excellent reproducibility . Therefore, the techniques are promising candidates as quantitative noninvasive biomarkers for early OA.…”

3D adiabatic T1ρ prepared ultrashort echo time cones sequence for whole knee imaging

“…Recently, a novel imaging technique was developed in which trains of adiabatic full passage (AFP) pulses are used to generate T 1ρ relaxation (AdiabT 1ρ ) . AdiabT 1ρ has been reported to be less sensitive to the magic angle effect compared with both CW‐T 1ρ and T 2 relaxations in bovine cartilage studies .…”

“…In addition, AdiabT 1ρ has other advantages over CW spin‐lock sequences. Most notably, adiabatic pulses are less sensitive to the spatial inhomogeneity of the transmit RF magnetic field compared with CW spin‐lock pulses, and the flexibility of AFP pulse design allows moderation of RF power deposition . Moreover, an extended range of frequencies or correlation times are effectively involved in the spin lattice relaxation when using AFP pulses, which may provide more information on the physicochemical mechanisms underlying pathological changes in tissues.…”