Validation and Performance Assessment of a Preclinical SiPM-Based SPECT/MRI Insert

Carminati, Marco; Baratelli, F. M.; Occhipinti, Michele; Erlandsson, Kjell; Nagy, Kálmán; Nyitrai, Z.; Czeller, M.; Kühne, André; Niendorf, Thoralf; Valtorta, Silvia; Belloli, Sara; Moresco, R.M.; Savi, Annarita; Iadanza, Antonella; Falini, Andrea; Politi, Letterio S.; Cadioli, Marcello; Hutton, Brian F.; Fiorini, C.

doi:10.1109/trpms.2019.2893377

Cited by 14 publications

(11 citation statements)

References 23 publications

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“…The study also shows that this detector has minimum impact over MR image quality and achieves a good MRI compatibility [21]. The preclinical scanner based on this detector has achieved a resolution of 0.9 mm across 15.6 mm FOV and a sensitivity of 0.11% with a multiple-pinhole collimator (nine holes of 0.8 mm × 0.8 mm) [28]. The clinical scanner achieves a spatial resolution of 8 mm and a sensitivity of 0.036% using multiple slit-slat collimator [29].…”

Section: Introductionmentioning

confidence: 83%

“…The ultra-high resolution is achieved by cutting the crystal into a sub-mm pixel. The INSERT project, which several groups in EU are working on, aims to develop preclinical and clinical SPECT/MRI systems for chemo therapy, and is on this path [14,21,[25][26][27][28][29]. The project developed a sub-mm resolution detector using CsI (TI) with SiPM readout [25].…”

Section: Introductionmentioning

confidence: 99%

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Design, Performance Evaluation, and Modeling of an Ultrahigh Resolution Detector Dedicated for Simultaneous SPECT/MRI

Lai

Cai

Tan

et al. 2022

IEEE Trans. Radiat. Plasma Med. Sci.

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Section: Introductionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Design, Performance Evaluation, and Modeling of an Ultrahigh Resolution Detector Dedicated for Simultaneous SPECT/MRI

Lai

Cai

Tan

et al. 2022

IEEE Trans. Radiat. Plasma Med. Sci.

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“…The INSERT detector technology has undergone preliminary characterization of the SPECT system, [10], however complete MR compatibility has only been validated in the preclinical system, [11]. Future work will set out to test the system in a clinical MR environment and to streamline calibration and acquisition procedures for routine use.…”

Section: Conclusion and Discussionmentioning

confidence: 99%

Acquisition Correction and Reconstruction for a Clinical SPECT/MRI Insert

Morahan

Erlandsson

D’Adda

et al. 2019

2019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)

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The development of the first clinical simultaneous Single Photon Emission Computed Tomography (SPECT) and Magnetic Resonance Imaging (MRI) system was carried out within the INSERT project. The INSERT scanner was constructed under the initial project, but its performance was not fully evaluated; here we have reconstructed the first images on the SPECT system. Calibration and acquisition protocols were developed and used to establish the clinical feasibility of the system. The image reconstruction procedures were implemented on the first phantom images in order to assess the system's imaging capabilities. This study solved issues involving incomplete data sets and pixel failure in the prototype detector system. The final images determined a measure of trans-axial image resolution, giving average values of 9.14 mm and 6.75 mm in the radial and tangential directions respectively. The work carried out on the complete system produced several clinical phantom images which utilized the capabilities of both SPECT and MRI.

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“…The SPECT scanner is placed inside a standard MRI scanner, connected to a custom-designed and shielded transceiver coil placed inside the bore of the SPECT static ring, which contains gamma cameras and the collimator. Figure 8 b shows the preclinical version of the scanner [ 45 ], while Figure 8 c shows the clinical prototype [ 46 ], the only existing MRI-compatible SiPM-based SPECT insert for human brain imaging. The main features of the two instruments are summarized in Table 1 .…”

Section: Multi-modal Medical Imagingmentioning

confidence: 99%

Challenges for Microelectronics in Non-Invasive Medical Diagnostics

Carminati

Fiorini

2020

Sensors

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Microelectronics is emerging, sometimes with changing fortunes, as a key enabling technology in diagnostics. This paper reviews some recent results and technical challenges which still need to be addressed in terms of the design of CMOS analog application specific integrated circuits (ASICs) and their integration in the surrounding systems, in order to consolidate this technological paradigm. Open issues are discussed from two, apparently distant but complementary, points of view: micro-analytical devices, combining microfluidics with affinity bio-sensing, and gamma cameras for simultaneous multi-modal imaging, namely scintigraphy and magnetic resonance imaging (MRI). The role of integrated circuits is central in both application domains. In portable analytical platforms, ASICs offer miniaturization and tackle the noise/power dissipation trade-off. The integration of CMOS chips with microfluidics poses multiple open technological issues. In multi-modal imaging, now that the compatibility of the acquisition chains (thousands of Silicon Photo-Multipliers channels) of gamma detectors with Tesla-level magnetic fields has been demonstrated, other development directions, enabled by microelectronics, can be envisioned in particular for single-photon emission tomography (SPECT): a faster and simplified operation, for instance, to allow transportable applications (bed-side) and hardware pre-processing that reduces the number of output signals and the image reconstruction time.

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Validation and Performance Assessment of a Preclinical SiPM-Based SPECT/MRI Insert

Cited by 14 publications

References 23 publications

Design, Performance Evaluation, and Modeling of an Ultrahigh Resolution Detector Dedicated for Simultaneous SPECT/MRI

Design, Performance Evaluation, and Modeling of an Ultrahigh Resolution Detector Dedicated for Simultaneous SPECT/MRI

Acquisition Correction and Reconstruction for a Clinical SPECT/MRI Insert

Challenges for Microelectronics in Non-Invasive Medical Diagnostics

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