Validation List no. 212. Valid publication of new names and new combinations effectively published outside the IJSEM

Oren, Aharon; Göker, Markus

doi:10.1099/ijsem.0.005931

Cited by 5 publications

(1 citation statement)

References 50 publications

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“…The strain Caldimonas brevitalea DSM 7029 (previously named Schlegella brevitalea) was used as a heterologous host to produce Myxobacterial and Burkholderial secondary metabolites, such as epothilone, chitinimides, rhizomide, etc. [28,29]. The Gram-negative model bacterium B. thailandensis E264 harbors an abundance of BGCs (23), which produces nonribosomal peptides (NRPs), PKs, bacteriocins, terpenes, various hybrid molecules, etc.…”

Section: Introductionmentioning

confidence: 99%

The Genomic-Driven Discovery of Glutarimide-Containing Derivatives from Burkholderia gladioli

Chen,

Bai,

Sun

et al. 2023

Molecules

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Glutarimide-containing polyketides exhibiting potent antitumor and antimicrobial activities were encoded via conserved module blocks in various strains that favor the genomic mining of these family compounds. The bioinformatic analysis of the genome of Burkholderia gladioli ATCC 10248 showed a silent trans-AT PKS biosynthetic gene cluster (BGC) on chromosome 2 (Chr2C8), which was predicted to produce new glutarimide-containing derivatives. Then, the silent polyketide synthase gene cluster was successfully activated via in situ promoter insertion and heterologous expression. As a result, seven glutarimide-containing analogs, including five new ones, gladiofungins D-H (3–7), and two known gladiofungin A/gladiostatin (1) and 2 (named gladiofungin C), were isolated from the fermentation of the activated mutant. Their structures were elucidated through the analysis of HR-ESI-MS and NMR spectroscopy. The structural diversities of gladiofungins may be due to the degradation of the butenolide group in gladiofungin A (1) during the fermentation and extraction process. Bioactivity screening showed that 2 and 4 had moderate anti-inflammatory activities. Thus, genome mining combined with promoter engineering and heterologous expression were proved to be effective strategies for the pathway-specific activation of the silent BGCs for the directional discovery of new natural products.

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Section: Introductionmentioning

confidence: 99%

The Genomic-Driven Discovery of Glutarimide-Containing Derivatives from Burkholderia gladioli

Chen,

Bai,

Sun

et al. 2023

Molecules

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Update on novel validly published and included bacterial taxa derived from human clinical specimens and taxonomic revisions published in 2023

Carella,

Carroll,

Munson

2024

J Clin Microbiol

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Taxonomy is a systematic practice in which microorganisms are granted names to facilitate and standardize multi-disciplinary communication. We summarize novel bacterial taxa derived from human clinical material that were published in peer-reviewed literature and/or included by the International Journal of Systematic and Evolutionary Microbiology during calendar year 2023, as well as taxonomic revisions that have been published/included by the same entity. While the majority of newly discovered facultative and anaerobic organisms were derived from microbiome surveillance, noteworthy novel taxa in the realm of pathogenicity potential include those related to Aerococcus spp., several Corynebacterium spp., Exercitatus varius gen. nov., sp. nov., and Mycoplasma phocimorsus sp. nov. With respect to nomenclature revision, the Bacillus and Clostridium genera continue to be visited annually. Creation of novel anaerobic Gram-negative bacillus genera Hallella , Hoylesella , Leyella , Segatella , and Xylanibacter impacted several Bacteroides spp. and Prevotella spp. Additional studies are necessary to ascertain the clinical significance of several of these microbes.

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An update on novel taxa and revised taxonomic status of bacteria isolated from domestic companion and agricultural animals described in 2023

Lawhon,

Burbick,

Krueger

et al. 2024

J Clin Microbiol

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With the proliferation of abundant bacterial genomic data comes the recognition of new organisms as well as a better understanding of the relatedness of known bacteria. Recognizing the associated taxonomic changes enhances communication and understanding about the significance of novel organisms and deeper understanding of known pathogens. This review addresses the addition of multiple gastrointestinal bacteria that form the normal microbiota in a variety of animals including honeybees as well as novel bacteria from domestic animals including an alpha-hemolytic Streptococcus species from guinea pigs, two Moraxella spp. from cows and goats, a new Capnocytophaga species from cats, a thermophilic Campylobacter species from pigs, and the new Exercitatus genus in Family Pasteurellaceae . Several revisions to the nomenclature also appeared in 2023 including the change of Clostridium spiroforme, which causes anorexia and diarrhea in domestic rabbits, to Thomasclavelia spiroformis comb. nov. and Mannheimia ovis to Mannheimia pernigra .

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Validation List no. 212. Valid publication of new names and new combinations effectively published outside the IJSEM

Cited by 5 publications

References 50 publications

The Genomic-Driven Discovery of Glutarimide-Containing Derivatives from Burkholderia gladioli

The Genomic-Driven Discovery of Glutarimide-Containing Derivatives from Burkholderia gladioli

Update on novel validly published and included bacterial taxa derived from human clinical specimens and taxonomic revisions published in 2023

An update on novel taxa and revised taxonomic status of bacteria isolated from domestic companion and agricultural animals described in 2023

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