Validation of a questionnaire measuring the regulation of autonomic function

Kretzler, Matthias; Feder, Gene; Laue, HB von; Zerm, Roland; Reif, Marcus; Girke, M.; Matthes, Harald; Gutenbrunner, C.; Heckmann, Christian

doi:10.1186/1472-6882-8-26

Cited by 32 publications

(50 citation statements)

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“…For patients undergoing chemotherapy, the State-aR scale recorded a significant loss of regulation in the sum-and rest-activity subscales, compared to the Trait-aR scale. Cross-sectional studies have repeatedly shown a lowered Trait-aR for breast cancer patients vs. healthy individuals [22,25,23]. Hence the State-aR captures an increase in sleep problems and problems in daily functioning which is related to fatigue during chemo-or radiotherapy [14,38-40].…”

Section: Discussionmentioning

confidence: 99%

“…The Trait-aR on the other hand can be conceived as a combination of autonomic constitution and current regulation [22]. The new State-aR sum-scale as Opposed to the Trait-scale in a cross-sectional context shows a significantly lower aR of the cancer group compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

“…aR is effected by constitution, gender, age and illness. Under physiological conditions it is a stable trait, but in the context of illness or psychological disturbance a loss of regulation can occur which leads to a decreased aR [22]. We have validated a short version of Trait-aR with 12 items capturing the rest-activity- and orthostatic-circulatory regulation [23] and a longer version with 18 items which includes digestive regulation, too [22].…”

Section: Introductionmentioning

confidence: 99%

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Validation of the state version questionnaire on autonomic regulation (state-aR) for cancer patients

et al. 2011

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ObjectivesCurrent quality of life inventories used in oncology mainly measure the effects of chemo- or radiotherapy alongside functional and role scales. A new approach is to measure the autonomic state of regulation with the trait-inventory of autonomic regulation (Trait-aR). Loss of Trait-aR has been shown in different medical conditions such as breast cancer (BC) but not in colorectal cancer patients (CRC). In this paper we report the validation of a new state autonomic regulation scale (State-aR) of the last week.MethodsStudy 1 included 114 participants: (41 women/16 men with cancer and 57 age- and gender-matched healthy people) to conduct a reliability-, factor- and validity-analysis. Concurrent and convergent validity was evaluated with Trait-aR, Fatigue-Numeri-cal-Scale, Hospital Anxiety and Depression Scale (HADS-D) and the self-regulation scale, 65 participants were retested. Study 2 completed 42 participants: 17 with BC and 25 with CRC receiving chemotherapy. The State-aR was administered prior, during and after chemotherapy for measuring responsiveness.ResultsThe factor analysis loaded to four subscales of State-aR (rest-activity, orthostatic-circulatory, thermosweating and digestive regulation) with a: Cronbach-α rα = 0.77-0.83 and a test-retest-reliability rrt = 0.60-0.80. The sum- and sub scales correlated with their concurrent subscales in the Trait-aR (0.48-0.74) and with the sum-scale moderately with all convergent criteria (r = 0.41 --0.44; p < 0.001). During chemotherapy the State-aR-sum and rest-activity-scale decreased significantly compared to the change in the Trait-aR (p < 0.05).ConclusionsThese findings support that the state autonomic regulation scale has satisfactory to good reliability, good validity and acceptable responsiveness in the context of chemotherapy treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Validation of the state version questionnaire on autonomic regulation (state-aR) for cancer patients

et al. 2011

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“…The questionnaire ranges from 18 (minimal aR) to 54 (maximum aR), has satisfying to good reliability (Cronbach's α: r α = .75, test-retest reliability r rt = .85), and good validity. 41 In breast cancer patients, different studies have reported reduced aR and particularly loss of rest/activity regulation in recurrence-free breast cancer patients. 41, 42 We applied the aR scale for capturing possible improvements in the regulation of autonomic functions under intervention in a more holistic view.…”

Section: Methodsmentioning

confidence: 99%

Multimodal Therapy Concept and Aerobic Training in Breast Cancer Patients With Chronic Cancer-Related Fatigue

et al. 2012

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Hypothese: Cancer-related fatigue (CRF) and sleep disorders are some of the most wearing and common symptoms in disease-free breast cancer patients (BC). Aerobic training (AT) is the treatment with the best available evidence, even though it seems to be insufficient with regards to improvements in cognitive fatigue. We introduced a new multimodal therapy concept (MM) consisting of psycho-, sleep-education and new approaches based on anthroposophic medicine such as eurythmy and painting therapy. Study design: This pilot study will test the implementation of MM and yield first results of the MM and AE in our centres. Methods: 31 out of 34 patients suffering from BC and CRF were fully assessed in a ten-week intervention study. 21 patients chose MM and 10 decided on AT. CRF was measured with the help of the Cancer Fatigue Scale (CFS-D), and the global quality of sleep was measured with the Pittsburgh Sleep Quality Index (PSQI). We also captured autonomic regulation (aR) and patients' satisfaction with questionnaires. Statistical analysis was done with SAS 9.1.3 for windows. Results:The new MM therapy can be implemented with high satisfaction among patients. Significant improvements were found in the MM group with regards to CFS-D, global quality of sleep, sleep efficiency (PSQI), aR and rest/activity regulation compared to baseline (all p<0.05). In the AT group aR orthostatic-circulatory and rest/activity regulation improved significantly (p<0.05), too. However, no improvement in cognitive fatigue was seen in either group. Conclusion: The multimodal therapy concept was feasible and improved cancer fatigue, sleep quality, autonomic and rest-/ activity regulation in breast cancer patients. It may therefore constitute a valuable treatment option in addition to aerobic training for BC patients with CRF. A further study with larger sample size needs to be carried out to assess the efficacy of combined multimodal-aerobic therapy.

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“…Latente Hyper-und Hypothyreosen (MW = 24,4) weisen ebenso eine signifikant erniedrigte aR auf[15][16][17]23].…”

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Zincum valerianicum beim Restless-Legs-Syndrom

Kröz¹,

Anders²,

Brauer³

et al. 2009

EHK

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➤ Das Restless-Legs-Syndrom (RLS) oder Ekbom-Syndrom [9] ist in den letzten 10 Jahren zunehmend in das medizinische Bewusstsein gerückt. Es hat eine hohe sozialmedizinische Relevanz. So werden für Deutschland Prävalenzen von 2-7% angegeben [5]. Nach der MEMO-Studie beträgt die Prävalenz bei über 65-Jährigen 9,8%, bei älteren Frauen sogar 14% [22]. Trotz einer wachsenden Zahl an wissenschaftlichen Publikationen (Recherche: Restless Zusammenfassung In der retrospektiven Auswertung wurden 28 Patienten mit Restless-Legs-Syndrom (RLS) analysiert, die am Medizinischen Versorgungszentrum Havelhöhe mit Zincum valerianicum D 3 bzw. Cuprum aceticum/Zincum valerianicum behandelt wurden. Es wird das konzeptionelle Krankheitsverständnis des RLS aus Sicht der Anthroposophischen Medizin vorgestellt, wonach eine niedrige autonome Regulation besteht. Pathophysiologisch wird der damit assoziierte Eisenmangel beim idiopathischen RLS im Kontext aktueller schlafmedizinischer Konzepte und Therapien diskutiert. Die Kombinationstherapie aus Zincum valerianicum D 3 und ggf. Eisen führt zu einer Verbesserung der RLS-Beschwerden in der International Restless Legs Severity Scale. Schlüsselwörter Anthroposophische Medizin, autonome Regulation, Restless-Legs-Syndrom, Zincum valerianicum. AbstractIn a retrospective evaluation 28 patients with Restless Legs Syndrome (RLS) are analyzed, who were treated at the Medizinisches Versorgungszentrum Havelhöhe with Zincum valerianicum D 3 and/or Cuprum aceticum/Zincum valerianicum. The disease conception of the RLS is presented from the view of the Anthroposophic Medicine. Pathophysiologically the associated lack of iron in case of the idiopathic RLS is discussed in the context of current sleep-medical concepts and therapies. The combination therapy of Zincum valerianicum D 3 and iron (if necessary) results in an improvement of RLS-complaints at the International Restless Legs Severity Scale.

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Validation of a questionnaire measuring the regulation of autonomic function

Cited by 32 publications

References 50 publications

Validation of the state version questionnaire on autonomic regulation (state-aR) for cancer patients

Validation of the state version questionnaire on autonomic regulation (state-aR) for cancer patients

Multimodal Therapy Concept and Aerobic Training in Breast Cancer Patients With Chronic Cancer-Related Fatigue

Zincum valerianicum beim Restless-Legs-Syndrom

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