Validation of a radial diffusive sampler for measuring occupational exposure to 1,3-butadiene

Carrieri, Mariella; Bartolucci, Giovanni Battista; Paci, Enrico; Sacco, Paolo; Pigini, Daniela; Zaratin, Laura; Cottica, Danilo; Scapellato, Maria Luisa; Tranfo, Giovanna

doi:10.1016/j.chroma.2014.02.018

Cited by 13 publications

(6 citation statements)

References 21 publications

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“…The exposure assessments were done in August 2019. Radiello passive samplers were used for measuring personal exposure to 1, 3-Butadiene [12,13]. After exposure, the chemical substances collected on sorbing cartridges were desorbed by thermal desorption procedure and analyzed by GC/MS.…”

Section: Samplingmentioning

confidence: 99%

Application of biological monitoring for exposure assessment of 1.3 Butadiene

Ahmadkhaniha

Ghoochani

Rastkari

2020

J Environ Health Sci Engineer

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Background 1, 3-Butadiene is an important industrial compound. Based on sufficient evidence of carcinogenicity in laboratory animals and humans, the International Agency for Research on Cancer, in 1999, classified 1, 3-Butadiene as a probable carcinogen to humans (group 2A). The potential for exposure to vehicle exhaust containing these chemical compounds is very noticeable in urban locations. Exposure to incomplete combustion of gasoline has been a long time concern in many occupational fields, including policemen, service stations, and the petroleum industry but in Iran has rarely been studied. Methods This study designed to determine the exposure levels for traffic policemen and gas station workers during routine work shift, by biological monitoring. With this aim, 25 policemen engaged in traffic control, 25 gas station workers and 25 occupationally non-exposed persons were investigated. Spot urine samples were obtained prior to and at the end of the work shift from each subject. The urinary levels of selected urinary metabolites (MHBMA and DHBMA) were determined by using LC-MS/MS. Results There were significant differences among the mean urinary concentrations of DHBMA in pre-shift samples of policemen, gas station workers and occupationally non-exposed persons. The mean urinary concentrations of DHBMA differed significantly among post-shift samples of policemen and gas station (ANOVA: p < 0.05 and Kruskal-Wallis test: p < 0.05). Conclusions There was a significant difference in DHBMA concentrations between job categories (p < 0.05 by ANOVA and Kruskal-Wallis test), and policemen and gas station workers were found to be probably the most exposed groups in this study.

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Section: Samplingmentioning

confidence: 99%

Application of biological monitoring for exposure assessment of 1.3 Butadiene

Ahmadkhaniha

Ghoochani

Rastkari

2020

J Environ Health Sci Engineer

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“…Among other biomarkers, DHBMA, THBMA, and EB-GII have natural background that may be caused by endogenous sources, thus restricting their sensitivity [ 113 , 124 , 130 , 133 ]. Specifically, DHBMA fails to reflect the changes in the external exposure doses in some studies [ 137 , 162 ]; in particular, a study found that the DHBMA levels did not change after cessation of smoking, whereas the levels of MHBMA and the biomarkers of other VOCs rapidly decreased [ 137 ]. The difference in the THBMA concentrations between smokers and non-smokers is small (the data of smokers is only 58% higher than that of non-smokers), although it is statistically significant ( p < 0.01) [ 129 ].…”

Section: Introductionmentioning

confidence: 99%

1,3-Butadiene: a ubiquitous environmental mutagen and its associations with diseases

Chen

Zhang

2022

Genes and Environ

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Abstract1,3-Butadiene (BD) is a petrochemical manufactured in high volumes. It is a human carcinogen and can induce lymphohematopoietic cancers, particularly leukemia, in occupationally-exposed workers. BD is an air pollutant with the major environmental sources being automobile exhaust and tobacco smoke. It is one of the major constituents and is considered the most carcinogenic compound in cigarette smoke. The BD concentrations in urban areas usually vary between 0.01 and 3.3 μg/m3 but can be significantly higher in some microenvironments. For BD exposure of the general population, microenvironments, particularly indoor microenvironments, are the primary determinant and environmental tobacco smoke is the main contributor. BD has high cancer risk and has been ranked the second or the third in the environmental pollutants monitored in most urban areas, with the cancer risks exceeding 10-5. Mutagenicity/carcinogenicity of BD is mediated by its genotoxic metabolites but the specific metabolite(s) responsible for the effects in humans have not been determined. BD can be bioactivated to yield three mutagenic epoxide metabolites by cytochrome P450 enzymes, or potentially be biotransformed into a mutagenic chlorohydrin by myeloperoxidase, a peroxidase almost specifically present in neutrophils and monocytes. Several urinary BD biomarkers have been developed, among which N-acetyl-S-(4-hydroxy-2-buten-1-yl)-L-cysteine is the most sensitive and is suitable for biomonitoring BD exposure in the general population. Exposure to BD has been associated with leukemia, cardiovascular disease, and possibly reproductive effects, and may be associated with several cancers, autism, and asthma in children. Collectively, BD is a ubiquitous pollutant that has been associated with a range of adverse health effects and diseases with children being a subpopulation with potentially greater susceptibility. Its adverse effects on human health may have been underestimated and more studies are needed.

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“…1,3-Butadiene (BD), a major industrial chemical, has been widely used in the production of synthetic rubbers, latexes and polymers. 1,2 BD is known to have a carcinogenic effect on humans, therefore, it has been classied as Class 1 carcinogen by the International Agency for Research on Cancer (IARC). 3,4 Since BD is ubiquitous in the environment, humans are commonly suffered from BD exposure due to its presence at workplaces, in polluted air, in automobile exhaust and in tobacco smoke.…”

Section: Introductionmentioning

confidence: 99%

“…2,3,[7][8][9] Among these methods, high performance liquid chromatography-mass spectrometry (HPLC-MS/MS) has been widely used in many recent studies. 1,8,12,13 Compared with other analytical methods, HPLC-MS/MS could provide information on the molecular weight, peak purity and partial structure. Thus, it was usually applied, in particular, to increase the reliability of target identication.…”

Section: Introductionmentioning

confidence: 99%