Validation of an optimized method for the determination of iodine in human breast milk by inductively coupled plasma mass spectrometry (ICPMS) after tetramethylammonium hydroxide extraction

Huynh, Diem Thi Ngoc; Zhou, Shao Jia; Gibson, Robert A.; Palmer, Lyndon T.; Mühlhäusler, Beverly S.

doi:10.1016/j.jtemb.2014.07.005

Cited by 41 publications

(34 citation statements)

References 30 publications

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“…Studies reporting BMIC using the SandellKolthoff method without reporting information on external quality control should be interpreted cautiously. ICP-MS is the gold standard for determination of lowiodine concentrations in complex matrices (21,22,26,29,30) and the preferred method for BMIC. The data demonstrate the importance of the choice of ICP-MS quantification procedure for BMIC.…”

Section: Discussionmentioning

confidence: 99%

“…One study found differences in BMIC between fore-and hind-milk samples (17) while another did not (18). Broad ranges of BMIC have been reported in iodine-sufficient countries (9)(10)(11)19), but comparing BMIC across studies is difficult because of differences in study design, analytical methods, and the lack of external quality control (9,17,(20)(21)(22)(23)(24).…”

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confidence: 99%

“…Breast milk is a complex sample matrix (20,21,25), and inductively coupled plasma mass spectrometry (ICP-MS) is considered the standard method for iodine determination in such matrices, providing high levels of accuracy and precision and low detection limits (20)(21)(22)(23)26). However, obtaining accurate measurements using ICP-MS requires optimization of sample preparation and measurement parameters (20)(21)(22)(23)26).…”

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confidence: 99%

“…However, obtaining accurate measurements using ICP-MS requires optimization of sample preparation and measurement parameters (20)(21)(22)(23)26). Isotope dilution analysis (IDA) for ICP-MS uses the determination of isotope intensity ratios for quantification and is a promising approach for improving iodine measurements in breast milk.…”

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confidence: 99%

“…Isotope dilution analysis (IDA) for ICP-MS uses the determination of isotope intensity ratios for quantification and is a promising approach for improving iodine measurements in breast milk. This is because, compared with conventional standard curve applications, IDA allows for correction for losses, matrix effects, and instrumental drifts (20,21,(25)(26)(27)(28).…”

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confidence: 99%

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Optimization of a New Mass Spectrometry Method for Measurement of Breast Milk Iodine Concentrations and an Assessment of the Effect of Analytic Method and Timing of Within-Feed Sample Collection on Breast Milk Iodine Concentrations

Dold

Baumgartner

Zeder

et al. 2016

Thyroid

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Background: Breast milk iodine concentration (BMIC) may be an indicator of iodine status during lactation, but there are few data comparing different analytical methods or timing of sampling. The aims of this study were: (i) to optimize a new inductively coupled plasma mass spectrometry (ICP-MS) method; and (ii) to evaluate the effect of analytical method and timing of within-feed sample collection on BMIC. Methods: The colorimetric Sandell-Kolthoff method was evaluated with (a) or without (b) alkaline ashing, and ICP-MS was evaluated using a new 129 I isotope ratio approach including Tellurium (Te) for mass bias correction (c) or external standard curve (d). From iodine-sufficient lactating women (n = 97), three samples were collected within one breast-feeding session (fore-, mid-, and hind-feed samples) and BMIC was analyzed using (c) and (d). Results: Iodine recovery from NIST SRM1549a whole milk powder for methods (a)-(d) was 67%, 24%, 105%, and 102%, respectively. Intra-and inter-assay coefficients of variation for ICP-MS comparing (c) and (d) were 1.3% versus 5.6% ( p = 0.04) and 1.1% versus 2.4% ( p = 0.33). The limit of detection (LOD) was lower for (c) (0.26 lg/kg) than it was for (d) (2.54 lg/kg; p = 0.02). Using (c), the median [95% confidence interval (CI) obtained by bootstrap] BMIC (lg/kg) in foremilk (179 ) and in mid-feed milk (184 [CI 160-220]) were not significantly different ( p = 0.017), but were higher than in hindmilk (175 ; p < 0.001). In foremilk using (d), ; p < 0.001 vs. (c)). The variation in BMIC comparing (c) and (d) (13%) was greater than variation within feeding (5%; p < 0.001). Conclusions: Because of poor recoveries, (a) and (b) should not be used to measure BMIC. Compared with (d), (c) has the advantages of higher precision and a lower LOD. In iodine-sufficient women, BMIC shows low variation within a breast-feeding session, so timing of sampling is not a major determinant of BMIC.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

mentioning

confidence: 99%

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Optimization of a New Mass Spectrometry Method for Measurement of Breast Milk Iodine Concentrations and an Assessment of the Effect of Analytic Method and Timing of Within-Feed Sample Collection on Breast Milk Iodine Concentrations

Dold

Baumgartner

Zeder

et al. 2016

Thyroid

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Challenges and trends for halogen determination by inductively coupled plasma mass spectrometry: A review

Flores

Mello

Krzyzaniak

et al. 2020

Rapid Comm Mass Spectrometry

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Rationale In this review, works published in the past 25 years for fluorine, chlorine, bromine, and iodine determination in several matrices by inductively coupled plasma mass spectrometry (ICP‐MS) were covered. Usually, the determination of halogens has been performed by ICP‐MS using a previous sample preparation step or, more recently, by direct analysis of solid or liquid samples. Methods Methods based on combustion, extraction, pyrohydrolysis, sample dilution in organic or aqueous medium, and wet digestion, among others, are discussed. Moreover, the recent applications of methods based on laser ablation (LA) and electrothermal vaporization (ETV) coupled to ICP‐MS are discussed. Results The main challenge for methods using sample preparation has been to obtain a final solution compatible with ICP‐MS, as well as to overcome problems related to analyte losses and contamination. Interferences due to the presence of dissolved organic compounds in solution, enhancement or suppression of ionization of analytes, and related matrix effects have been of concern when using ICP‐MS. For the determination of halogens by ICP‐MS using LA and ETV systems, some limitations related to the difficulty of calibration are pointed out, impairing the widespread use of this approach. Conclusions A critical view is presented for further halogen determination by ICP‐MS, mainly for matrices considered difficult to digest using conventional protocols.

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Selective oxidative etching of CTAC-stabilized multi-branched gold nanoparticles: application in spectral sensing of iodide ions

et al. 2018

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Validation of an optimized method for the determination of iodine in human breast milk by inductively coupled plasma mass spectrometry (ICPMS) after tetramethylammonium hydroxide extraction

Cited by 41 publications

References 30 publications

Optimization of a New Mass Spectrometry Method for Measurement of Breast Milk Iodine Concentrations and an Assessment of the Effect of Analytic Method and Timing of Within-Feed Sample Collection on Breast Milk Iodine Concentrations

Optimization of a New Mass Spectrometry Method for Measurement of Breast Milk Iodine Concentrations and an Assessment of the Effect of Analytic Method and Timing of Within-Feed Sample Collection on Breast Milk Iodine Concentrations

Challenges and trends for halogen determination by inductively coupled plasma mass spectrometry: A review

Selective oxidative etching of CTAC-stabilized multi-branched gold nanoparticles: application in spectral sensing of iodide ions

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