Validation of hair ethyl glucuronide using transdermal monitoring and self‐reported alcohol use in women of childbearing potential

Blair, Andrea L.; Chiaf, Ashleigh L.; Crockett, Erica K.; Teague, T. Kent; Croff, Julie M.

doi:10.1002/npr2.12151

Cited by 3 publications

(2 citation statements)

References 50 publications

(130 reference statements)

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“…Background levels are still occasionally found in abstainers [ 75 ], and levels tend in general to be higher with high body mass index or in subjects with kidney damage [ 75 , 76 ]. Hair EtG measurements may also be less sensitive at low alcohol intakes (≤ one drink per day) [ 77 ]…”

Section: Resultsmentioning

confidence: 99%

Biomarkers of moderate alcohol intake and alcoholic beverages: a systematic literature review

et al. 2023

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The predominant source of alcohol in the diet is alcoholic beverages, including beer, wine, spirits and liquors, sweet wine, and ciders. Self-reported alcohol intakes are likely to be influenced by measurement error, thus affecting the accuracy and precision of currently established epidemiological associations between alcohol itself, alcoholic beverage consumption, and health or disease. Therefore, a more objective assessment of alcohol intake would be very valuable, which may be established through biomarkers of food intake (BFIs). Several direct and indirect alcohol intake biomarkers have been proposed in forensic and clinical contexts to assess recent or longer-term intakes. Protocols for performing systematic reviews in this field, as well as for assessing the validity of candidate BFIs, have been developed within the Food Biomarker Alliance (FoodBAll) project. The aim of this systematic review is to list and validate biomarkers of ethanol intake per se excluding markers of abuse, but including biomarkers related to common categories of alcoholic beverages. Validation of the proposed candidate biomarker(s) for alcohol itself and for each alcoholic beverage was done according to the published guideline for biomarker reviews. In conclusion, common biomarkers of alcohol intake, e.g., as ethyl glucuronide, ethyl sulfate, fatty acid ethyl esters, and phosphatidyl ethanol, show considerable inter-individual response, especially at low to moderate intakes, and need further development and improved validation, while BFIs for beer and wine are highly promising and may help in more accurate intake assessments for these specific beverages.

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Section: Resultsmentioning

confidence: 99%

Biomarkers of moderate alcohol intake and alcoholic beverages: a systematic literature review

et al. 2023

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“…In the last years, the excessive alcohol intake dramatically increased in adolescents and young adults, thus becoming both a health problem and an economic one, as it leads to an increase in the number of work incapacitated days [ 30 , 31 ].…”

Section: ⧉ Discussionmentioning

confidence: 99%

Hepatic injuries resulting from chronic alcohol abuse identified by forensics

Crauciuc

Stan²,

Rîşcanu³

et al. 2021

Rom J Morphol Embryol

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Alcohol intake is largely spread all over the world, although it is well-known that it causes important changes of the liver, from liver steatosis, hepatitis to liver cirrhosis. The study we performed on 93 patients deceased in suspicious circumstances and brought to the Institute of Forensic Medicine, Iaşi, Romania, confirmed through the determination of Ethyl glucuronide, that these were alcohol consumers. The macroscopic analysis during necropsy highlighted the presence of alcoholic liver disease (ALD), while microscopy studies confirmed the macroscopic observations. The immunohistochemical studies showed the existence of a chronic liver inflammation, the transdifferentiation of stellate hepatic cells, the activation of Kupffer cells, important changes of the hepatic vascular network, hepatocyte necrosis, lipid loadings and the progression of liver fibrosis process.

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