Validation of nomogram-revised risk index and comparison with other models for extranodal nasal-type NK/T-cell lymphoma in the modern chemotherapy era: indication for prognostication and clinical decision-making

Abstract

Derived from our original nomogram study by using the risk variables from multivariable analyses in the derivation cohort of 1383 patients with extranodal NK/T-cell lymphoma, nasal-type (ENKTCL) who were mostly treated with anthracyclinebased chemotherapy, we propose an easily used nomogram-revised risk index (NRI), validated it and compared with Ann Arbor staging, the International Prognostic Index (IPI), Korean Prognostic Index (KPI), and prognostic index of natural killer lymphoma (PINK) for overall survival (OS) prediction by examining calibration, discrimination, and decision curve analysis in a validation cohort of 1582 patients primarily treated with non-anthracycline-based chemotherapy. The calibration of the NRI showed satisfactory for predicting 3-and 5-year OS in the validation cohort. The Harrell's C-index and integrated Brier score (IBS) of the NRI for OS prediction demonstrated a better performance than that of the Ann Arbor staging system, IPI, KPI, and PINK. Decision curve analysis of the NRI also showed a superior outcome. The NRI is a promising tool for stratifying patients with ENKTCL into risk groups for designing clinical trials and for selecting appropriate individualized treatment. 1234567890();,:1234567890();,:

Clinical Significance of Circulating Exosomal PD-L1 and Soluble PD-L1 in Nasal-type NK/T-cell Lymphoma Patients Receiving VIPD Containing Chemotherapy

“…Our results support previous observations that the baseline SUVmax correlates with prognosis in ENKTCL [35]. The PINK score represents a new model used to predict outcomes in ENKTCL patients treated with non-anthracycline-based therapies, and this model was con rmed in subsequent studies [7,36]. Our research assessed the impact of the PINK on prognosis and found that a high PINK score was associated with a worse outcome.…”

Risk‐based, response‐adapted therapy for early‐stage extranodal nasal‐type NK/T‐cell lymphoma in the modern chemotherapy era: A China Lymphoma Collaborative Group study

“…In the ANT-based CT era, comparative studies do not show the survival benefit of adding CT to RT for early-stage ENKTCL 5,8,36,37 ; the advantage of additional CT has only been observed in high-risk early-stage patients. 10 Moving to the modern CT era, 33 the NRI here remained satisfactory for discriminating between low-risk and high-risk groups, and identified intermediate-risk to high-risk patients receiving substantial benefit from additional CT. Even with more effective CT, adding non-ANT-based CT to RT did not confer survival benefit for low-risk patients; survival benefit was still only observed in intermediate-risk/high-risk patients.…”

“…Patients were staged using the Ann Arbor staging system and stratified using the nomogram-revised risk index (NRI). 32,33 Verification and restaging based on original imaging reports were carried out during data cleaning process. Ann Arbor stage I was defined as primary extranodal lesion with or without adjacent invasion of the structure or organs, whereas stage II was defined as primary extranodal lesion with involvement of regional lymph nodes on the same side of the diaphragm.…”

“…Primary tumor invasion was defined as the presence of primary disease that extended into neighboring structures or organs, or involvement of multiple (≥2), contiguous primary sites. 23 As described previously, 32,33…”

Development and external validation of a nomogram to predict the risk of Upper gastrointestinal precancerous lesions in a non‐high‐incidence area

“…Nomograms are accurate and precise tools by creating an intuitive graph of a statistical predictive model for estimating risk, by correlating the relationship between parameters and various cancer prognosis parameters such as metastatic probability, overall survival (OS), and disease risk. 17,18 In our previous study, precancerous lesions (PL) of UGC screening are the major the detection result in non-high-incidence area. And to data, there has never been a study intended to develop a nomogram to predict the risk of UGPL.…”